Biological sciences topic list of research papers
-
Identification of the small molecule compound which induces hepatic differentiation of human mesenchymal stem cells
Abstract Human mesenchymal stem cells (MSCs) are expected to have utility as a cell source in regenerative medicine. Because we previously reported that suppression of the Wnt/β-catenin signal enhances hepatic differentiation of human MSCs, we...
2015 / Noriko Itaba, Tomohiko Sakabe, Keita Kanki, Junya Azumi, Hiroki Shimizu, et al. -
Maternal DNA Methylation Regulates Early Trophoblast Development
Summary Critical roles for DNA methylation in embryonic development are well established, but less is known about its roles during trophoblast development, the extraembryonic lineage that gives rise to the placenta. We dissected the role of DNA...
2016 / Miguel R. Branco, Michelle King, Vicente Perez-Garcia, Aaron B. Bogutz, Matthew Caley, et al. -
Azole resistance in Candida spp. isolated from Catú Lake, Ceará, Brazil: an efflux-pump-mediated mechanism2016 / Raimunda S.N. Brilhante, Manoel A.N. Paiva, Célia M.S. Sampaio, Débora S.C.M. Castelo-Branco, Carlos E.C. Teixeira, et al.
-
Neurotrophic activity of jiadifenolide on neuronal precursor cells derived from human induced pluripotent stem cells
Abstract Although jiadifenolide has been reported to neurotrophin-like activity in primary cultured rat cortical neurons, it is unknown on that of activity in human neurons. Thus, we aimed to assess neurotrophin-like activity by jiadifenolide in...
2016 / Masaki Shoji, Megumi Nishioka, Hiroki Minato, Kenichi Harada, Miwa Kubo, et al. -
Migratory corridors of adult female Kemp's ridley turtles in the Gulf of Mexico
Abstract For many marine species, locations of migratory pathways are not well defined. We used satellite telemetry and switching state-space modeling (SSM) to define the migratory corridor used by Kemp's ridley turtles (Lepidochelys kempii) in the...
2015 / Donna J. Shaver, Kristen M. Hart, Ikuko Fujisaki, Cynthia Rubio, Autumn R. Sartain-Iverson, et al. -
Using DNA profiling to investigate human-mediated translocations of an invasive species
Abstract The reconstruction of invasion history is the goal or foundation of many investigations of biological invasions. This study applies DNA profiling to investigate the sources and vectors of new propagules, to detect illegal human-mediated...
2016 / A.L. Signorile, D.C. Reuman, P.W.W. Lurz, S. Bertolino, C. Carbone, et al. -
Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors
Summary The mechanisms by which intrinsically disordered proteins engage in rapid and highly selective binding is a subject of considerable interest and represents a central paradigm to nuclear pore complex (NPC) function, where nuclear transport...
2015 / Sigrid Milles, Davide Mercadante, Iker Valle Aramburu, Malene Ringkjøbing Jensen, Niccolò Banterle, et al. -
Dorsal Raphe Dopamine Neurons Represent the Experience of Social Isolation
Summary The motivation to seek social contact may arise from either positive or negative emotional states, as social interaction can be rewarding and social isolation can be aversive. While ventral tegmental area (VTA) dopamine (DA) neurons may...
2016 / Gillian A. Matthews, Edward H. Nieh, Caitlin M. Vander Weele, Sarah A. Halbert, Roma V. Pradhan, et al. -
Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause
Summary Mouse embryonic stem cells (ESCs) are maintained in a naive ground state of pluripotency in the presence of MEK and GSK3 inhibitors. Here, we show that ground-state ESCs express low Myc levels. Deletion of both c-myc and N-myc (dKO) or...
2016 / Roberta Scognamiglio, Nina Cabezas-Wallscheid, Marc Christian Thier, Sandro Altamura, Alejandro Reyes, et al. -
Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors
Summary Primary prostate cancer almost always has a luminal phenotype. However, little is known about the stem/progenitor properties of transformed cells within tumors. Using the aggressive Pten/Tp53-null mouse model of prostate cancer, we show that ...
2015 / Supreet Agarwal, Paul G. Hynes, Heather S. Tillman, Ross Lake, Wassim G. Abou-Kheir, et al. -
The effect of oil sands process-affected water and model naphthenic acids on photosynthesis and growth in Emiliania huxleyi and Chlorella vulgaris
Abstract Naphthenic acids (NAs) are among the most toxic organic pollutants present in oil sands process waters (OSPW) and enter marine and freshwater environments through natural and anthropogenic sources. We investigated the effects of the acid...
2015 / Jessica Beddow, Richard J. Johnson, Tracy Lawson, Mark N. Breckels, Richard J. Webster, et al. -
Ageing-induced changes in the redox status of peripheral motor nerves imply an effect on redox signalling rather than oxidative damage
Abstract Ageing is associated with loss of skeletal muscle fibres, atrophy of the remaining fibres and weakness. These changes in muscle are accompanied by disruption of motor neurons and neuromuscular junctions although the direct relationship...
2016 / Brian McDonagh, Siobhan M. Scullion, Aphrodite Vasilaki, Natalie Pollock, Anne McArdle, et al. -
Transcriptional profile of immediate response to ionizing radiation exposure
Abstract Astronauts participating in long duration space missions are likely to be exposed to ionizing radiation associated with highly energetic and charged heavy particles. Previously proposed gene biomarkers for radiation exposure include...
2015 / Eric C. Rouchka, Robert M. Flight, Brigitte H. Fasciotto, Rosendo Estrada, John W. Eaton, et al. -
Lysosome-Associated Membrane Proteins (LAMP) Maintain Pancreatic Acinar Cell Homeostasis: LAMP-2–Deficient Mice Develop Pancreatitis
Background & Aims The pathogenic mechanism of pancreatitis is poorly understood. Recent evidence implicates defective autophagy in pancreatitis responses; however, the pathways mediating impaired autophagy in pancreas remain largely unknown....
2015 / Olga A. Mareninova, Matthias Sendler, Sudarshan Ravi Malla, Iskandar Yakubov, Samuel W. French, et al. -
Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory
Abstract The present study examined memory function in Tc1 mice, a transchromosomic model of Down syndrome (DS). Tc1 mice demonstrated an unusual delay-dependent deficit in recognition memory. More specifically, Tc1 mice showed intact immediate...
2016 / Jessica H. Hall, Frances K. Wiseman, Elizabeth M.C. Fisher, Victor L.J. Tybulewicz, John L. Harwood, et al. -
Evolution, turnovers and spatial variation of the gastropod fauna of the late Miocene biodiversity hotspot Lake Pannon
Abstract Lake Pannon constituted the biggest hotspot of biodiversity in the late Cenozoic of Europe, comprising a total diversity of almost 600 gastropod species. The gastropod fauna of this huge brackish system, which existed over about seven...
2015 / Thomas A. Neubauer, Mathias Harzhauser, Oleg Mandic, Andreas Kroh, Elisavet Georgopoulou -
Role of metabolite transporters in source-sink carbon allocation2013 / Frank Ludewig, Ulf-Ingo Flügge
-
Fatty acid nitroalkenes induce resistance to ischemic cardiac injury by modulating mitochondrial respiration at complex II
Abstract Nitro-fatty acids (NO2-FA) are metabolic and inflammatory-derived electrophiles that mediate pleiotropic signaling actions. It was hypothesized that NO2-FA would impact mitochondrial redox reactions to induce tissue-protective metabolic...
2015 / Jeffrey R. Koenitzer, Gustavo Bonacci, Steven R. Woodcock, Chen-Shan Chen, Nadiezhda Cantu-Medellin, et al. -
A study into the potential role of Survivin localization in resistance to drug-induced apoptosis2008 / H. Angell
-
Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity
Abstract Objective A disturbed day-night rhythm is associated with metabolic perturbations that can lead to obesity and type 2 diabetes mellitus (T2DM). In skeletal muscle, a reduced oxidative capacity is also associated with the...
2016 / Dirk van Moorsel, Jan Hansen, Bas Havekes, Frank A.J.L. Scheer, Johanna A. Jörgensen, et al.