Biological sciences topic list of research papers
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Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks
Summary Embryogenesis is remarkably robust to segregating mutations and environmental variation; under a range of conditions, embryos of a given species develop into stereotypically patterned organisms. Such robustness is thought to be conferred, in ...
2015 / Enrico Cannavò, Pierre Khoueiry, David A. Garfield, Paul Geeleher, Thomas Zichner, et al. -
Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche
Background & Aims Cancer stem cells (CSCs) are thought to be persistent in tumours due to their chemoresistance and to cause relapse and metastasis. Hepatic carcinomas displaying hepatic progenitor cell (HPC) features have been associated...
2015 / Olivier Govaere, Jasper Wouters, Michaela Petz, Yves-Paul Vandewynckel, Kathleen Van den Eynde, et al. -
Daily intake of β-cryptoxanthin prevents bone loss by preferential disturbance of osteoclastic activation in ovariectomized mice
Abstract Although β-cryptoxanthin, a xanthophyll carotenoid, has been shown to exert an anabolic effect on bone calcification, little attention has been paid thus far to the precise mechanism of bone remodeling. Daily oral administration of...
2015 / Kakeru Ozaki, Maika Okamoto, Kazuya Fukasawa, Takashi Iezaki, Yuki Onishi, et al. -
“Young at heart”: Regenerative potential linked to immature cardiac phenotypes
Abstract The adult human myocardium is incapable of regeneration; yet, the zebrafish (Danio rerio) can regenerate damaged myocardium. Similar to the zebrafish heart, hearts of neonatal, but not adult mice are capable of myocardial regeneration. We...
2016 / Renata S.M. Gomes, Philipp Skroblin, Alex B. Munster, Hannah Tomlins, Sarah R. Langley, et al. -
Whole transcriptome analysis for T cell receptor-affinity and IRF4-regulated clonal expansion of T cells
Abstract Clonal population expansion of T cells during an immune response is dependent on the affinity of the T cell receptor (TCR) for its antigen [1]. However, there is little understanding of how this process is controlled transcriptionally. We...
2014 / Wei Shi, Kevin Man, Gordon K. Smyth, Stephen L. Nutt, Axel Kallies -
Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption
Abstract Objective The family of acyl-CoA synthetase enzymes (ACSL) activates fatty acids within cells to generate long chain fatty acyl CoA (FACoA). The differing metabolic fates of FACoAs such as incorporation into neutral...
2016 / Thomas A. Bowman, Kayleigh R. O'Keeffe, Theresa D'Aquila, Qing Wu Yan, John D. Griffin, et al. -
Artificial microRNA-derived resistance to Cassava brown streak disease
Abstract Artificial miRNAs (amiRNA) were generated targeting conserved sequences within the genomes of the two causal agents of Cassava brown streak disease (CBSD): Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV)....
2016 / Henry Wagaba, Basavaprabhu L. Patil, Settumba Mukasa, Titus Alicai, Claude M. Fauquet, et al. -
Metformin improves the angiogenic potential of human CD34+ cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction2016 / Sherin Bakhashab, Fahad W. Ahmed, Hans-Juergen Schulten, Ayat Bashir, Sajjad Karim, et al.
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Novel integrative genomic tool for interrogating lithium response in bipolar disorder2015 / J G Hunsberger, F L Chibane, A G Elkahloun, R Henderson, R Singh, et al.
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HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle2013 / B. G. Drew, V. Ribas, J. A. Le, D. C. Henstridge, J. Phun, et al.
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Insulin-like peptide 5 is a microbially regulated peptide that promotes hepatic glucose production
Abstract Objective Insulin-like peptide 5 (INSL5) is a recently identified gut hormone that is produced predominantly by L-cells in the colon, but its function is unclear. We have previously shown that colonic expression of the...
2016 / Ying Shiuan Lee, Filipe De Vadder, Valentina Tremaroli, Anita Wichmann, Gilles Mithieux, et al. -
Dataset for genotyping validation of cytochrome P450 2A6 whole-gene deletion (CYP2A6*4) by real-time polymerase chain reaction platforms
Abstract This data article contains a supplementary figure and validation data relating to the research article entitled “Genotyping of wild-type cytochrome P450 2A6 and whole-gene deletion using human blood samples and a multiplex real-time...
2015 / Makiko Shimizu, Tomoki Koyama, Izumi Kishimoto, Hiroshi Yamazaki -
A real-time PCR-based quantitative assay for 3-methylcytosine demethylase activity of ALKBH3
Abstract Human AlkB homolog 3 (ALKBH3), a homolog of the Escherichia coli protein AlkB, demethylates 1-methyladenine and 3-methylcytosine (3-meC) in single-stranded DNA and RNA by oxidative demethylation. Immunohistochemical analyses on clinical...
2016 / Yuko Ueda, Kaori Kitae, Ikumi Ooshio, Yasuyuki Fusamae, Megumi Kawaguchi, et al. -
Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques
Summary Gut microbes can profoundly modulate mucosal barrier-promoting Th17 cells in mammals. A salient feature of HIV/simian immunodeficiency virus (SIV) immunopathogenesis is the loss of Th17 cells, which has been linked to increased activity of...
2015 / Ivan Vujkovic-Cvijin, Louise A. Swainson, Simon N. Chu, Alexandra M. Ortiz, Clark A. Santee, et al. -
A physical perspective on cytoplasmic streaming2015 / R. E. Goldstein, J.-W. van de Meent
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IL-22 Defect During Streptococcus pneumoniae Infection Triggers Exacerbation of Chronic Obstructive Pulmonary Disease
Abstract Progression of chronic obstructive pulmonary disease (COPD) is linked to episodes of exacerbations caused by bacterial infections due to Streptococcus pneumoniae. Our objective was to identify during COPD, factors of susceptibility to...
2015 / Muriel Pichavant, Riti Sharan, Olivier Le Rouzic, Cécile Olivier, Florence Hennegrave, et al. -
A quantitative assessment of the content of hematopoietic stem cells in mouse and human endosteal-bone marrow: a simple and rapid method for the isolation of mouse central bone marrow2015 / Maya M. Mahajan, Betty Cheng, Ashley I. Beyer, Usha S. Mulvaney, Matt B. Wilkinson, et al.
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Complete genome sequence of the moderately thermophilic mineral-sulfide-oxidizing firmicute Sulfobacillus acidophilus type strain (NALT)2012 / Iain Anderson, Olga Chertkov, Amy Chen, Elizabeth Saunders, Alla Lapidus, et al.
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The anti-inflammatory and antifibrotic effects of Coreopsis tinctoria Nutt on high-glucose-fat diet and streptozotocin-induced diabetic renal damage in rats2015 / Lan Yao, Linlin Li, Xinxia Li, Hui Li, Yujie Zhang, et al.
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Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation
Abstract Pseudomonas aeruginosa is an opportunistic pathogen that induces severe lung infections such as ventilator-associated pneumonia and acute lung injury. Under these conditions, the bacterium diminishes epithelial...
2016 / Catherine Cott, Roland Thuenauer, Alessia Landi, Katja Kühn, Samuel Juillot, et al.