Biological sciences topic list of research papers
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Variants in TRIM22 that Affect NOD2 Signaling Are Associated With Very Early Onset Inflammatory Bowel Disease
Background & Aims Severe forms of inflammatory bowel disease (IBD) that develop in very young children can be caused by variants in a single gene. We performed whole-exome sequence (WES) analysis to identify genetic factors that might cause...
2016 / Qi Li, Cheng Hiang Lee, Lauren A. Peters, Lucas A. Mastropaolo, Cornelia Thoeni, et al. -
Formation of vascular network structures within cardiac cell sheets from mouse embryonic stem cells
Abstract Bioengineered cardiac tissues represent a promising strategy for regenerative medicine. However, methods of vascularization and suitable cell sources for tissue engineering and regenerative medicine have not yet been established. In this...
2015 / Shinako Masuda, Katsuhisa Matsuura, Mie Anazawa, Takahiro Iwamiya, Tatsuya Shimizu, et al. -
Guidance of Drosophila Mushroom Body Axons Depends upon DRL-Wnt Receptor Cleavage in the Brain Dorsomedial Lineage Precursors
Summary In vivo axon pathfinding mechanisms in the neuron-dense brain remain relatively poorly characterized. We study the Drosophila mushroom body (MB) axons, whose α and β branches connect to different brain areas. We show that the Ryk family WNT5 ...
2015 / Elodie Reynaud, Liza L. Lahaye, Ana Boulanger, Iveta M. Petrova, Claire Marquilly, et al. -
DEPDC1B Coordinates De-adhesion Events and Cell-Cycle Progression at Mitosis
Summary Cells entering mitosis become rounded, lose attachment to the substrate, and increase their cortical rigidity. Pivotal to these events is the dismantling of focal adhesions (FAs). How mitotic reshaping is linked to commitment to divide is...
2014 / Stefano Marchesi, Francesca Montani, Gianluca Deflorian, Rocco D’Antuono, Alessandro Cuomo, et al. -
Expression Quantitative Trait Loci and Receptor Pharmacology Implicate Arg1 and the GABA-A Receptor as Therapeutic Targets in Neuroblastoma
Summary The development of targeted therapeutics for neuroblastoma, the third most common tumor in children, has been limited by a poor understanding of growth signaling mechanisms unique to the peripheral nerve precursors from which tumors arise....
2014 / Christopher S. Hackett, David A. Quigley, Robyn A. Wong, Justin Chen, Christine Cheng, et al. -
Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice
Summary Hypothalamic ribosomal S6K1 has been suggested as a point of convergence for hormonal and nutrient signals in the regulation of feeding behavior, bodyweight, and glucose metabolism. However, the long-term effects of manipulating hypothalamic ...
2015 / Mark A. Smith, Loukia Katsouri, Elaine E. Irvine, Mohammed K. Hankir, Silvia M.A. Pedroni, et al. -
Gene-expression analysis of cold-stress response in the sexually transmitted protist Trichomonas vaginalis
Abstract Background Trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common nonviral sexually transmitted disease in the world. This infection affects millions of individuals worldwide...
2014 / Yi-Kai Fang, Kuo-Yang Huang, Po-Jung Huang, Rose Lin, Mei Chao, et al. -
DHA-induced stress response in human colon cancer cells – Focus on oxidative stress and autophagy
ABSTRACT Polyunsaturated fatty acids (PUFAs) are important constituents of the diet and health benefits of omega-3/n−3 PUFAs, especially eicosapentaenoic acid (EPA, 20:5 n−3) and docosahexaenoic acid (DHA, 22:6 n−3) have been well documented in...
2015 / Kristine Pettersen, Vivi Talstad Monsen, Caroline Hild Hakvåg Pettersen, Hilde Bremseth Overland, Grete Pettersen, et al. -
Morphological and molecular characterization of fungus isolated from tropical bed bugs in Northern Peninsular Malaysia, Cimex hemipterus (Hemiptera: Cimicidae)
Abstract Objective To investigate some morphological and molecular characteristics of fungal parasites isolated from wild tropical bed bug, Cimex hemipterus. Methods ...
2015 / Abdul Hafiz Ab Majid, Zulaikha Zahran, Abd Hafis Abd Rahim, Nor Azliza Ismail, Wardah Abdul Rahman, et al. -
Genetic Diversity of Acacia mangium Seed Orchard in Wonogiri Indonesia Using Microsatellite Markers2012 / Vivi Yuskianti, Keiya Isoda
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Two distinct knockout approaches highlight a critical role for p53 in rat development2012 / Masaki Kawamata, Takahiro Ochiya
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A novel EcGH3 gene with a different expression pattern in quinclorac-resistant and susceptible barnyardgrass (Echinochloa crus-galli)
Abstract Some plant GH3 genes are specifically induced by auxin within minutes and play important roles in plant growth and development. A GH3 cDNA was isolated from barnyardgrass. The gene, designated EcGH3.1 (Genebank Number: JN241678), has a...
2016 / Gang Li, Ming Fei Xu, Li Ping Chen, Lei Ming Cai, Lian Yang Bai, et al. -
Effect of Irradiation on Incidence of Post-Transplant Lymphoproliferative Disorder after Hematopoietic Cell Transplantation in Miniature Swine
Abstract Post-transplant lymphoproliferative disease (PTLD) is a major complication of clinical organ and cell transplantation. Conditioning and immunosuppressive regimens that significantly impair T cell immunity, including depleting antibodies and ...
2015 / Abraham J. Matar, Aarti R. Patil, Ahmad Al-Musa, Isabel Hanekamp, David H. Sachs, et al. -
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells
Summary To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we generated a prognostic LSC-associated miRNA signature derived from functionally validated subpopulations of AML samples. For one signature miRNA,...
2016 / Eric R. Lechman, Bernhard Gentner, Stanley W.K. Ng, Erwin M. Schoof, Peter van Galen, et al. -
Liquid-like behavior of chromatin
Eukaryotic chromatin is a negatively charged long polymer composed of genomic DNA, histones, and various proteins. The charged property causes the chromatin structure to be dynamically changed. These dynamic changes are critical for genome functions such as gene...
2016 / Kazuhiro Maeshima, Satoru Ide, Kayo Hibino, Masaki Sasai -
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes2016 / Minako Imamura, Atsushi Takahashi, Toshimasa Yamauchi, Kazuo Hara, Kazuki Yasuda, et al.
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Characterization of PIP2 aquaporins in Saccharum hybrids
Abstract Aquaporins (AQPs) are proteins that facilitate the transport of water, small neutral solutes and gases across membranes and have an important role in plant physiology and drought stress responses. The sugarcane (Saccharum spp.)...
2015 / Larissa Mara de Andrade, Paula Macedo Nobile, Rafael Vasconcelos Ribeiro, João Felipe Nebó Carlos de Oliveira, Antonio Vargas de Oliveira Figueira, et al. -
IFNL4 ss469415590 polymorphism contributes to treatment decisions in patients with chronic hepatitis C virus genotype 1b, but not 2a, infection
Abstract Recently, the dinucleotide variant ss469415590 (TT/ΔG) in a novel gene, interferon lambda 4 (IFNL4), was identified as a stronger predictor of hepatitis C virus (HCV) clearance in individuals of African ancestry compared with rs12979860. We ...
2016 / Ruihong Wu, Xiumei Chi, Xiaomei Wang, Haibo Sun, Juan Lv, et al. -
Genomic and Functional Overlap between Somatic and Germline Chromosomal Rearrangements
Summary Genomic rearrangements are a common cause of human congenital abnormalities. However, their origin and consequences are poorly understood. We performed molecular analysis of two patients with congenital disease who carried de novo genomic...
2014 / Sebastiaan van Heesch, Marieke Simonis, Markus J. van Roosmalen, Vamsee Pillalamarri, Harrison Brand, et al. -
Xeno-Free and Defined Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large-Eyed Preclinical Model
Summary Human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells could replace lost tissue in geographic atrophy (GA) but efficacy has yet to be demonstrated in a large-eyed model. Also, production of hESC-RPE has not yet been ...
2015 / Alvaro Plaza Reyes, Sandra Petrus-Reurer, Liselotte Antonsson, Sonya Stenfelt, Hammurabi Bartuma, et al.