Biological sciences topic list of research papers
-
Cabo II: Immunology and Gene Therapy2003 /
-
Derivation of human embryonic stem cell from spinal muscular atrophy patient
Abstract We established a human embryonic stem cell (hESC) line chHES-427 from the abnormal embryo carrying homozygous deletion of exon 7 of survival motor neuron gene (SMN). This cell line maintained a normal karyotype 46, XX during long-term...
2016 / Pingyuan Xie, Hao Zhou, Xiaoying Zhou, Xiaomeng Zhao, Juan Du, et al. -
Promiscuous plasmid replication in thermophiles: Use of a novel hyperthermophilic replicon for genetic manipulation of Clostridium thermocellum at its optimum growth temperature
Abstract Clostridium thermocellum is a leading candidate for the consolidated bioprocessing of lignocellulosic biomass for the production of fuels and chemicals. A limitation to the engineering of this strain is the...
2016 / Joseph Groom, Daehwan Chung, Daniel G. Olson, Lee R. Lynd, Adam M. Guss, et al. -
Metadata management for high content screening in OMERO
Abstract High content screening (HCS) experiments create a classic data management challenge—multiple, large sets of heterogeneous structured and unstructured data, that must be integrated and linked to produce a set of “final” results. These...
2015 / Simon Li, Sébastien Besson, Colin Blackburn, Mark Carroll, Richard K. Ferguson, et al. -
Illumina next generation sequencing data and expression microarrays data from retinoblastoma and medulloblastoma tissues
Abstract Retinoblastoma (Rb) is a pediatric intraocular malignancy and probably the most robust clinical model on which genetic predisposition to develop cancer has been demonstrated. Since deletions in chromosome 13 have been described in this...
2016 / A.J. García-Chequer, A. Méndez-Tenorio, G. Olguín-López, C. Sánchez-Vallejo, P. Isa, et al. -
Increased responses in the somatosensory thalamus immediately after spinal cord injury
Abstract Spinal cord injury (SCI) involves large-scale deafferentation of supraspinal structures in the somatosensory system, producing well-known long-term effects at the thalamo-cortical level. We recently showed that SCI provokes immediate...
2015 / E. Alonso-Calviño, I. Martínez-Camero, E. Fernández-López, D. Humanes-Valera, G. Foffani, et al. -
PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids
Abstract Objectives Peroxisome proliferator-activated receptor γ coactivator 1 (PPARGCA1, PGC-1) transcriptional coactivators control gene programs important for nutrient metabolism. Islets of type 2 diabetic subjects have reduced...
2015 / Daniel Oropeza, Nathalie Jouvet, Khalil Bouyakdan, Gabrielle Perron, Lea-Jeanne Ringuette, et al. -
Production, in Pichia pastoris, of a recombinant monomeric mapacalcine, a protein with anti-ischemic properties
Abstract Mapacalcine is a small homodimeric protein of 19kDa with 9 disulfide bridges extracted from the Cliona vastifica sponge (Red Sea). It selectively blocks a calcium current insensitive to most calcium blockers. Specific receptors for...
2015 / A. Noubhani, D. Bégu, S. Chaignepain, H. Moha ou Maati, M. Borsotto, et al. -
Measuring the robustness of network community structure using assortativity
The existence of discrete social clusters, or ‘communities’, is a common feature of social networks in human and nonhuman animals. The level of such community structure in networks is typically measured using an index of modularity, Q. While modularity quantifies...
2016 / Daizaburo Shizuka, Damien R. Farine -
Evaluation of acetylcholinesterase inhibitory activity of Brazilian red macroalgae organic extracts2015 / Levi P. Machado, Luciana R. Carvalho, Maria Cláudia M. Young, Elaine M. Cardoso-Lopes, Danilo C. Centeno, et al.
-
Do antibody responses to the influenza vaccine persist year-round in the elderly? A systematic review and meta-analysis
Abstract Introduction The influenza vaccine is less immunogenic in older than younger adults, and the duration of protection is unclear. Determining if protection persists beyond a typical seasonal epidemic is important for...
2016 / Barnaby Young, Xiahong Zhao, Alex R. Cook, Christopher M. Parry, Annelies Wilder-Smith, et al. -
Architecture and Characteristics of Bacterial Nanotubes
Summary Bacteria display an array of contact-dependent interaction systems that have evolved to facilitate direct cell-to-cell communication. We have previously identified a mode of bacterial communication mediated by nanotubes bridging neighboring...
2016 / Gyanendra P. Dubey, Ganesh Babu Malli Mohan, Anna Dubrovsky, Triana Amen, Shai Tsipshtein, et al. -
Distribution and dynamics of electron transport complexes in cyanobacterial thylakoid membranes
Abstract The cyanobacterial thylakoid membrane represents a system that can carry out both oxygenic photosynthesis and respiration simultaneously. The organization, interactions and mobility of components of these two electron transport pathways are ...
2015 / Lu-Ning Liu -
Cardiomyocytes Derived from MHC-Homozygous Induced Pluripotent Stem Cells Exhibit Reduced Allogeneic Immunogenicity in MHC-Matched Non-human Primates
Summary Induced pluripotent stem cells (iPSCs) can serve as a source of cardiomyocytes (CMs) to treat end-stage heart failure; however, transplantation of genetically dissimilar iPSCs even within species (allogeneic) can induce immune rejection. We...
2016 / Takuji Kawamura, Shigeru Miyagawa, Satsuki Fukushima, Akira Maeda, Noriyuki Kashiyama, et al. -
Proteolytic Cleavage Governs Interleukin-11 Trans-signaling
Summary Interleukin (IL)-11 has been shown to be a crucial factor for intestinal tumorigenesis, lung carcinomas, and asthma. IL-11 is thought to exclusively mediate its biological functions through cell-type-specific expression of the membrane-bound ...
2016 / Juliane Lokau, Rebecca Nitz, Maria Agthe, Niloufar Monhasery, Samadhi Aparicio-Siegmund, et al. -
Upregulation of basolateral small conductance potassium channels (KCNQ1/KCNE3) in ulcerative colitis
Abstract Background Basolateral K+ channels hyperpolarize colonocytes to ensure Na+ (and thus water) absorption. Small conductance basolateral (KCNQ1/KCNE3) K+ channels have never been evaluated in human colon. We therefore...
2015 / Adel Al-Hazza, John Linley, Qadeer Aziz, Malcolm Hunter, Geoffrey Sandle -
Plant diversity in different bioclimatic zones in Tunisia
Abstract The Republic of Tunisia, located in northern Africa, faces various environmental challenges caused by anthropogenic practices such as overgrazing, deforestation, and desertification. The conversion of natural ecosystems is the major cause...
2016 / Hana You, Hyeyoung Jin, Abdelhamid Khaldi, Myeongja Kwak, Taeyoon Lee, et al. -
Life after logging in tropical forests of Borneo: A meta-analysis
Abstract Selectively logged tropical forests retain high species richness and functional diversity, but species composition changes after logging, suggesting that some species are more vulnerable to logging than others. We did a meta-analysis to...
2016 / David Costantini, David P. Edwards, Mirre J.P. Simons -
Efficient generation of pancreatic β-like cells from the mouse gallbladder
Abstract Direct reprogramming is a promising approach for the replacement of β cells in diabetes. Reprogramming of cells originating from the endodermal lineage, such as acinar cells in the pancreas, liver cells and gallbladder cells has been of...
2016 / Yuhan Wang, Feorillo Galivo, Carl Pelz, Annelise Haft, Jonghyeob Lee, et al. -
The missing links to link ubiquitin: Methods for the enzymatic production of polyubiquitin chains
Abstract Attachment of ubiquitin (Ub) as monoUb and polyUb chains of different lengths and linkages to proteins plays a dominant role in very different regulatory mechanisms. Therefore, the study of polyUb chains has assumed a central interest in...
2015 / Serena Faggiano, Caterina Alfano, Annalisa Pastore