Biological sciences topic list of research papers
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In vitro flubendazole-induced damage to vital tissues in adult females of the filarial nematode Brugia malayi
Abstract The use of a microfilaricidal drug for the control of onchocerciasis and lymphatic filariasis necessitates prolonged yearly dosing. Prospects for elimination or eradication of these diseases would be enhanced by availability of a...
2015 / Maeghan O'Neill, James F. Geary, Dalen W. Agnew, Charles D. Mackenzie, Timothy G. Geary -
Induction of Antioxidant and Heat Shock Protein Responses During Torpor in the Gray Mouse Lemur, Microcebus murinus
Abstract A natural tolerance of various environmental stresses is typically supported by various cytoprotective mechanisms that protect macromolecules and promote extended viability. Among these are antioxidant defenses that help to limit damage...
2015 / Cheng-Wei Wu, Kyle K. Biggar, Jing Zhang, Shannon N. Tessier, Fabien Pifferi, et al. -
Corticosterone suppresses vasotocin-enhanced clasping behavior in male rough-skinned newts by novel mechanisms interfering with V1a receptor availability and receptor-mediated endocytosis
Abstract In rough-skinned newts, Taricha granulosa, exposure to an acute stressor results in the rapid release of corticosterone (CORT), which suppresses the ability of vasotocin (VT) to enhance clasping behavior. CORT also suppresses VT-induced...
2014 / Audrey Davis, Emily Abraham, Erin McEvoy, Sarah Sonnenfeld, Christine Lewis, et al. -
Multiple-locus variable-number tandem repeat analysis of Leptospira interrogans and Leptospira borgpetersenii isolated from small feral and wild mammals in East Asia
Abstract Leptospira spp. are the causative agents of a worldwide zoonosis, leptospirosis, maintained by various mammals. Each Leptospira serovar is frequently associated with a particular maintenance host, and recently,...
2015 / Nobuo Koizumi, Hidemasa Izumiya, Jung-Jung Mu, Zbigniew Arent, Shou Okano, et al. -
Asynchrony of senescence among phenotypic traits in a wild mammal population
Abstract The degree to which changes in lifespan are coupled to changes in senescence in different physiological systems and phenotypic traits is a central question in biogerontology. It is underpinned by deeper biological questions about whether or ...
2015 / Adam D. Hayward, Jacob Moorad, Charlotte E. Regan, Camillo Berenos, Jill G. Pilkington, et al. -
MicroRNA-200c-141 and ∆Np63 are required for breast epithelial differentiation and branching morphogenesis
Abstract The epithelial compartment of the breast contains two lineages, the luminal- and the myoepithelial cells. D492 is a breast epithelial cell line with stem cell properties that forms branching epithelial structures in 3D culture with both...
2015 / Bylgja Hilmarsdóttir, Eirikur Briem, Valgardur Sigurdsson, Sigrídur Rut Franzdóttir, Markus Ringnér, et al. -
Viability of developmental stages of Schistosoma mansoni quantified with xCELLigence worm real-time motility assay (xWORM)
Abstract Infection with helminth parasites causes morbidity and mortality in billions of people and livestock worldwide. Where anthelmintic drugs are available, drug resistance is a major problem in livestock parasites, and a looming threat to...
2015 / Gabriel Rinaldi, Alex Loukas, Paul J. Brindley, Jeff T. Irelan, Michael J. Smout -
The generation of knock-in mice expressing fluorescently tagged galanin receptors 1 and 2
Abstract The neuropeptide galanin has diverse roles in the central and peripheral nervous systems, by activating the G protein-coupled receptors Gal1, Gal2 and the less studied Gal3 (GalR1–3 gene products). There is a wealth of data on expression of ...
2015 / Niall Kerr, Fiona E. Holmes, Sally-Ann Hobson, Penny Vanderplank, Alan Leard, et al. -
Full mtGenome reference data: Development and characterization of 588 forensic-quality haplotypes representing three U.S. populations
Abstract Though investigations into the use of massively parallel sequencing technologies for the generation of complete mitochondrial genome (mtGenome) profiles from difficult forensic specimens are well underway in multiple laboratories, the high...
2014 / Rebecca S. Just, Melissa K. Scheible, Spence A. Fast, Kimberly Sturk-Andreaggi, Alexander W. Röck, et al. -
Acquisition of pluripotency through continued environmental influence on OCT4-induced plastic human fibroblasts
Abstract The combination of OCT4 expression and short-term exposure to reprogramming media induces a state of transcriptional plasticity in human fibroblasts, capable of responding to changes in the extracellular environment that facilitate direct...
2015 / Kyle R. Salci, Jung Bok Lee, Ryan R. Mitchell, Luca Orlando, Aline Fiebig-Comyn, et al. -
A new pma1 mutation identified in a chronologically long-lived fission yeast mutant
Abstract We isolated a chronologically long-lived mutant of Schizosaccharomyces pombe and found a new mutation in pma1 + that encoded for an essential P-type proton ATPase. An Asp-138 to Asn mutation resulted in reduced Pma1...
2014 / Chikako Naito, Hirokazu Ito, Tomoko Oshiro, Hokuto Ohtsuka, Hiroshi Murakami, et al. -
Frequencies of Gag-restricted T-cell escape “footprints” differ across HIV-1 clades A1 and D chronically infected Ugandans irrespective of host HLA B alleles
Abstract Objective(s) We evaluated relationships between critical Gag T-cell escape mutations and concomitant T-cell responses to determine whether HLA-restricted Gag mutations that confer protection, occur at similar rates in a...
2015 / Jennifer Serwanga, Ritah Nakiboneka, Susan Mugaba, Brian Magambo, Nicaise Ndembi, et al. -
Nanog induces hyperplasia without initiating tumors
Abstract Though expression of the homeobox transcription factor Nanog is generally restricted to pluripotent cells and early germ cells, many contradictory reports about Nanog's involvement in tumorigenesis exist. To address this, a modified Tet-On...
2014 / Gerrit Fischedick, Guangming Wu, Kenjiro Adachi, Marcos J. Araúzo-Bravo, Boris Greber, et al. -
BoLA-6*01301 and BoLA-6*01302, two allelic variants of the A18 haplotype, present the same epitope from the Tp1 antigen of Theileria parva
Abstract We have recently shown that the BoLA-A18 variant haplotype (BoLA-6*01302) is more prevalent than the BoLA-A18 haplotype (BoLA-6*01301) in a sample of Holstein/Friesian cattle in Kenya. These MHC class I allelic variants differ by a single...
2015 / N. Svitek, E. Awino, V. Nene, L. Steinaa -
Physiological competition of brain phenylalanine accretion: Initial pharmacokinetic analyses of aminoisobutyric and methylaminoisobutyric acids in Pahenu2−/− mice
Abstract Objective Initial studies on the use of non-physiological amino acids (NPAAs) to block the accretion of Phe in the brain of Pahenu2−/− mice revealed that 2-aminoisobutyrate (AIB) and...
2015 / Kara R. Vogel, Garrett R. Ainslie, Brian Phillips, Erland Arning, Teodoro Bottiglieri, et al. -
Ubiquitin is a versatile scaffold protein for the generation of molecules with de novo binding and advantageous drug-like properties
Abstract In the search for effective therapeutic strategies, protein-based biologicals are under intense development. While monoclonal antibodies represent the majority of these drugs, other innovative approaches are exploring the use of scaffold...
2015 / Florian Job, Florian Settele, Susan Lorey, Chris Rundfeldt, Lars Baumann, et al. -
Co-expression of GAD67 and choline acetyltransferase reveals a novel neuronal phenotype in the mouse medulla oblongata
Abstract GABAergic and cholinergic systems play an important part in autonomic pathways. To determine the distribution of the enzymes responsible for the production of GABA and acetylcholine in areas involved in autonomic control in the mouse...
2015 / Jittima Gotts, Lucy Atkinson, Ian J. Edwards, Yuchio Yanagawa, Susan A. Deuchars, et al. -
Longitudinal tracking of triple labeled umbilical cord derived mesenchymal stromal cells in a mouse model of Amyotrophic Lateral Sclerosis
Abstract The translational potential of cell therapy to humans requires a deep knowledge of the interaction between transplanted cells and host tissues. In this study, we evaluate the behavior of umbilical cord mesenchymal stromal cells (UC-MSCs),...
2015 / Martina Bruna Violatto, Chiara Santangelo, Chiara Capelli, Roberta Frapolli, Raffaele Ferrari, et al. -
Custom mentholation of commercial cigarettes for research purposes
Abstract In the U.S. menthol remains the sole permitted characterizing cigarette flavor additive in part because efforts to link menthol cigarette use to increased tobacco-related disease risk have been inconclusive. To perform definitive studies,...
2014 / Ian C. MacGregor, Stephen B. Stanfill, Sydney M. Gordon, Douglas J. Turner, Jenny M. Butler, et al. -
Whole genome sequencing identifies circulating Beijing-lineage Mycobacterium tuberculosis strains in Guatemala and an associated urban outbreak
Summary Limited data are available regarding the molecular epidemiology of Mycobacterium tuberculosis (Mtb) strains circulating in Guatemala. Beijing-lineage Mtb strains have gained prevalence worldwide and are associated with increased virulence...
2015 / Joseph W. Saelens, Dalia Lau-Bonilla, Anneliese Moller, Narda Medina, Brenda Guzmán, et al.