Biological sciences topic list of research papers
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Stromal-Derived Factor-1α and Interleukin-7 Treatment Improves Homeostatic Proliferation of Naïve CD4+ T Cells after Allogeneic Stem Cell Transplantation
Abstract Graft-versus-host disease (GVHD) impairs immune reconstitution after allogeneic stem cell transplantation (allo-SCT) and effective therapies aimed at restoring T cell counts in GVHD patients have yet to be developed. During GVHD, CD4+ T...
2015 / Simon-David Gauthier, Dominique Leboeuf, Renaud Manuguerra-Gagné, Louis Gaboury, Martin Guimond -
Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice
Summary TET1/2/3 are methylcytosine dioxygenases that regulate cytosine hydroxymethylation. Tet1/2 are abundantly expressed in HSC/HPCs and are implicated in hematological malignancies. Tet2 deletion in mice causes myeloid malignancies, while...
2015 / Zhigang Zhao, Li Chen, Meelad M. Dawlaty, Feng Pan, Ophelia Weeks, et al. -
The Fas/CD95 Receptor Regulates the Death of Autoreactive B Cells and the Selection of Antigen-Specific B Cells2012 / Gabor Koncz, Anne-Odile Hueber
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The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer
Summary More potent targeting of the androgen receptor (AR) in advanced prostate cancer is driving an increased incidence of neuroendocrine prostate cancer (NEPC), an aggressive and treatment-resistant AR-negative variant. Its molecular pathogenesis ...
2015 / Shusuke Akamatsu, Alexander W. Wyatt, Dong Lin, Summer Lysakowski, Fan Zhang, et al. -
Antiplasmodial and cytotoxic activities of the constituents of Turraea robusta and Turraea nilotica
Abstract Ethnopharmacological relevance Turraea robusta and Turraea nilotica are African medicinal plants used for the treatment of a wide variety of diseases, including malaria. The genus Turraea is rich in...
2015 / Beatrice N. Irungu, Nicholas Adipo, Jennifer A. Orwa, Francis Kimani, Matthias Heydenreich, et al. -
Duodenal crypt health following exposure to Cr(VI): Micronucleus scoring, γ-H2AX immunostaining, and synchrotron X-ray fluorescence microscopy
Abstract Lifetime exposure to high concentrations of hexavalent chromium [Cr(VI)] in drinking water results in intestinal damage and an increase in duodenal tumors in B6C3F1 mice. To assess whether these tumors could be the result of a direct...
2015 / Chad M. Thompson, Jeffrey C. Wolf, Reem H. Elbekai, Madhav G. Paranjpe, Jennifer M. Seiter, et al. -
Training for eye contact modulates gaze following in dogs
Following human gaze in dogs and human infants can be considered a socially facilitated orientation response, which in object choice tasks is modulated by human-given ostensive cues. Despite their similarities to human infants, and extensive skills in reading...
2015 / Lisa J. Wallis, Friederike Range, Corsin A. Müller, Samuel Serisier, Ludwig Huber, et al. -
Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells
Abstract In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared to healthy neutrophil...
2015 / Elena A. Federzoni, Severin Gloor, Jing Jin, Deborah Shan-Krauer, Martin F. Fey, et al. -
In silico analyses of dystrophin Dp40 cellular distribution, nuclear export signals and structure modeling
Abstract Dystrophin Dp40 is the shortest protein encoded by the DMD (Duchenne muscular dystrophy) gene. This protein is unique since it lacks the C-terminal end of dystrophins. In this data article, we describe the subcellular localization, nuclear...
2015 / Alejandro Martínez-Herrera, Jorge Aragón, Rosa Ma. Bermúdez-Cruz, Ma. Luisa Bazán, Gabriela Soid-Raggi, et al. -
Seeing beyond the tip of the iceberg: A deep analysis of the venome of the Brazilian Rattlesnake, Crotalus durissus terrificus
Abstract The complete characterization of the snake venom protein components is a requirement for a systems-wide understanding of their biological context. In this work, we provide a deep proteomic characterization of Crotalus durissus terrificus...
2015 / Rafael D. Melani, Gabriel D.T. Araujo, Paulo C. Carvalho, Livia Goto, Fábio C.S. Nogueira, et al. -
Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury
Summary Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into the injured spinal cord in rodents and primates. Although remyelination of spared...
2015 / Soya Kawabata, Morito Takano, Yuko Numasawa-Kuroiwa, Go Itakura, Yoshiomi Kobayashi, et al. -
Potential seasonal calibration for palaeoenvironmental reconstruction using skeletal microstructures and strontium measurements from the cold-water coral Lophelia pertusa2014 / VINCENT MOUCHI, QUENTIN G. CROWLEY, ANDREW L. JACKSON, FRANK MCDERMOTT, XAVIER MONTEYS, et al.
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Lysosomal acid lipase deficiency – An under-recognized cause of dyslipidaemia and liver dysfunction
Abstract Lysosomal acid lipase deficiency (LAL-D) is a rare autosomal recessive lysosomal storage disease caused by deleterious mutations in the LIPA gene. The age at onset and rate of progression vary greatly and this may relate to the nature of...
2014 / Željko Reiner, Ornella Guardamagna, Devaki Nair, Handrean Soran, Kees Hovingh, et al. -
Immunological benefits by ginseng through reciprocal regulation of Th17 and Treg cells during cyclosporine-induced immunosuppression
Abstract Background It is not clear whether ginseng affects cyclosporine A (CsA)-induced desirable immunosuppressive action. In this study, we evaluated the immunological influence of combined treatment of ginseng with CsA. ...
2015 / Seong Beom Heo, Sun Woo Lim, Joo Yeon Jhun, Mi La Cho, Byung Ha Chung, et al. -
BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells
Summary Naive mouse embryonic stem cells (mESCs) are in a metastable state and fluctuate between inner cell mass- and epiblast-like phenotypes. Here, we show transient activation of the BMP-SMAD signaling pathway in mESCs containing a BMP-SMAD...
2015 / Maria Gomes Fernandes, Ruben Dries, Matthias S. Roost, Stefan Semrau, Ana de Melo Bernardo, et al. -
Immune Responses and Lassa Virus Infection2012 / Marion Russier, Delphine Pannetier, Sylvain Baize
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Effects of the endoparasitoid Cotesia chilonis (Hymenoptera: Braconidae) parasitism, venom, and calyx fluid on cellular and humoral immunity of its host Chilo suppressalis (Lepidoptera: Crambidae) larvae
Abstract The larval endoparasitoid Cotesia chilonis injects venom and bracoviruses into its host Chilo suppressalis during oviposition. Here we study the effects of the polydnavirus (PDV)-carrying endoparasitoid C. chilonis (Hymenoptera: Braconidae) ...
2015 / Zi-Wen Teng, Gang Xu, Shi-Yu Gan, Xuan Chen, Qi Fang, et al. -
The Sinocyclocheilus cavefish genome provides insights into cave adaptation2016 / Junxing Yang, Xiaoli Chen, Jie Bai, Dongming Fang, Ying Qiu, et al.
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Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle
Summary The molecular mechanisms by which aging affects stem cell number and function are poorly understood. Murine data have implicated cellular senescence in the loss of muscle stem cells with aging. Here, using human cells and by carrying out...
2015 / Anne Bigot, William J. Duddy, Zamalou G. Ouandaogo, Elisa Negroni, Virginie Mariot, et al. -
Ventral tegmental area dopaminergic lesion-induced depressive phenotype in the rat is reversed by deep brain stimulation of the medial forebrain bundle
Abstract DBS of the medial forebrain bundle (MFB) has been investigated clinically in major depressive disorder patients with rapid and long-term reduction of symptoms. In the context of chronic bilateral high frequency deep brain stimulation (DBS)...
2015 / L.L. Furlanetti, V.A. Coenen, M.D. Döbrössy