Biological sciences topic list of research papers
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Borrelia burgdorferi sensu lato-infected Ixodes ricinus collected from vegetation near the Arctic Circle
Abstract This is the first study to determine the density of questing Ixodes ricinus in northern Norway. It was performed at two sites in Brønnøy, which has been known for its tick permissive habitats for decades and is one of the northernmost...
2015 / Dag Hvidsten, Frode Stordal, Malin Lager, Bjørg Rognerud, Bjørn-Erik Kristiansen, et al. -
Effect of mutations on the thermostability of Aspergillus aculeatus β-1,4-galactanase
Abstract New variants of β-1,4-galactanase from the mesophilic organism Aspergillus aculeatus were designed using the structure of β-1,4-galactanase from the thermophile organism Myceliophthora thermophila as a template. Some of the variants were...
2015 / Søs Torpenholt, Leonardo De Maria, Mats H.M. Olsson, Lars H. Christensen, Michael Skjøt, et al. -
Genetic polymorphism of the human organic solute carrier protein 1 (hOSCP1) gene in Japanese patients with non-viral liver carcinoma
Abstract Human organic solute carrier protein 1 (hOSCP1) is a Na+-independent multispecific organic solute transporter. To date, several studies have revealed that gene mutations of the transporters are likely to be associated with some diseases;...
2014 / Mayumi Toda, Yasuna Kobayashi, Tomotake Koizumi, Koji Saito, Masayuki Ohbayashi, et al. -
Regulation of the PI3K/AKT Pathway and Fuel Utilization During Primate Torpor in the Gray Mouse Lemur, Microcebus murinus
Abstract Gray mouse lemurs (Microcebus murinus) from Madagascar present an excellent model for studies of torpor regulation in a primate species. In the present study, we analyzed the response of the insulin signaling pathway as well as controls on...
2015 / Shannon N. Tessier, Jing Zhang, Kyle K. Biggar, Cheng-Wei Wu, Fabien Pifferi, et al. -
CPU-12, a novel synthesized oxazolo[5,4-d]pyrimidine derivative, showed superior anti-angiogenic activity
Abstract Angiogenesis is a crucial requirement for malignant tumor growth, progression and metastasis. Tumor-derived factors stimulate formation of new blood vessels which actively support tumor growth and spread. Various of drugs have been applied...
2015 / Jiping Liu, Ya-Hui Deng, Ling Yang, Yijuan Chen, Manzo Lawali, et al. -
Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome
Abstract Neurogenesis impairment starting from early developmental stages is a key determinant of intellectual disability in Down syndrome (DS). Previous evidence provided a causal relationship between neurogenesis impairment and malfunctioning of...
2015 / Andrea Giacomini, Fiorenza Stagni, Stefania Trazzi, Sandra Guidi, Marco Emili, et al. -
Data supporting chitosan facilitates structure formation of the salivary gland by regulating the basement membrane components
Abstract To investigate the role of basement membrane (BM) in chitosan-mediated morphogenesis of the salivary glands, the embryonic submandibular gland (SMG) experimental model was used. Chitosan promotes branching at distinct stages in SMG...
2015 / Ya-Chuan Hsiao, Tsung-Lin Yang -
Wild chimpanzees are infected by Trypanosoma brucei
Abstract Although wild chimpanzees and other African great apes live in regions endemic for African sleeping sickness, very little is known about their trypanosome infections, mainly due to major difficulties in obtaining their blood samples. In...
2015 / Milan Jirků, Jan Votýpka, Klára J. Petrželková, Kateřina Jirků-Pomajbíková, Eva Kriegová, et al. -
MicroRNAs in Neural Stem Cells and Neurogenesis2012 / Hironori Kawahara, Takao Imai, Hideyuki Okano
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hESC Differentiation toward an Autonomic Neuronal Cell Fate Depends on Distinct Cues from the Co-Patterning Vasculature
Summary To gain insight into the cellular and molecular cues that promote neurovascular co-patterning at the earliest stages of human embryogenesis, we developed a human embryonic stem cell model to mimic the developing epiblast. Contact of...
2015 / Lisette M. Acevedo, Jeffrey N. Lindquist, Breda M. Walsh, Peik Sia, Flavio Cimadamore, et al. -
Characterization of type I interferon pathway during hepatic differentiation of human pluripotent stem cells and hepatitis C virus infection
Abstract Pluripotent stem cells are being actively studied as a cell source for regenerating damaged liver. For long-term survival of engrafting cells in the body, not only do the cells have to execute liver-specific function but also withstand the...
2015 / Joseph Ignatius Irudayam, Deisy Contreras, Lindsay Spurka, Aparna Subramanian, Jenieke Allen, et al. -
Biochemical characterization of FIKK8 – A unique protein kinase from the malaria parasite Plasmodium falciparum and other apicomplexans
Abstract FIKKs are protein kinases with distinctive sequence motifs found exclusively in Apicomplexa. Here, we report on the biochemical characterization of Plasmodium falciparum FIKK8 (PfFIKK8) and its Cryptosporidium parvum orthologue (CpFIKK) –...
2015 / Khan T. Osman, Hua Jane Lou, Wei Qiu, Verena Brand, Aled M. Edwards, et al. -
Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis
Abstract Deletion studies confirm Wnt, Notch and Myb transcriptional pathway engagement in intestinal tumorigenesis. Nevertheless, their contrasting and combined roles when activated have not been elucidated. This is important as these pathways are...
2014 / Markus Germann, Huiling Xu, Jordane Malaterre, Shienny Sampurno, Mathilde Huyghe, et al. -
Models of Breast Morphogenesis Based on Localization of Stem Cells in the Developing Mammary Lobule
Summary Characterization of normal breast stem cells is important for understanding their role in breast development and in breast cancer. However, the identity of these cells is a subject of controversy and their localization in the breast...
2015 / Gabriella Honeth, Tommaso Schiavinotto, Federico Vaggi, Rebecca Marlow, Tokuwa Kanno, et al. -
Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium–choroid with age
Abstract Dysregulation of the complement system has been implicated in the pathogenesis of age-related macular degeneration. To investigate consequences of altered complement regulation in the eye with age, we examined Cd59a complement regulator...
2015 / Philipp Herrmann, Jill A. Cowing, Enrico Cristante, Sidath E. Liyanage, Joana Ribeiro, et al. -
Differential adaptive responses to 1- or 2-day fasting in various mouse tissues revealed by quantitative PCR analysis
Abstract Dietary or caloric restriction confers various clinical benefits. Short-term fasting of mice is a common experimental procedure that may involve systemic metabolic remodeling, which may significantly affect experimental outputs. This study...
2015 / Junya Yamamoto, Shotaro Kamata, Asumi Miura, Tomoko Nagata, Ryo Kainuma, et al. -
Deletion of the Sm1 encoding motif in the lsm gene results in distinct changes in the transcriptome and enhanced swarming activity of Haloferax cells
Abstract Members of the Sm protein family are important for the cellular RNA metabolism in all three domains of life. The family includes archaeal and eukaryotic Lsm proteins, eukaryotic Sm proteins and archaeal and bacterial Hfq proteins. While...
2015 / Lisa-Katharina Maier, Juliane Benz, Susan Fischer, Martina Alstetter, Katharina Jaschinski, et al. -
The cooperative role of S1P3 with LYVE-1 in LMW-HA-induced lymphangiogenesis
Abstract Lymphangiogenesis, the formation of new lymph vessels, plays a significant role in the development and metastasis of various cancers. We and others have demonstrated that low molecular weight hyaluronan (LMW-HA) promotes lymphangiogenesis....
2015 / Mengsi Yu, Huizhen Zhang, Yiwen Liu, Yiqing He, Cuixia Yang, et al. -
Propagation of the Israeli vaccine strain of Anaplasma centrale in tick cell lines
Abstract Anaplasma centrale has been used in cattle as a live blood vaccine against the more pathogenic Anaplasma marginale for over 100 years. While A. marginale can be propagated in vitro in tick cell lines, facilitating...
2015 / Lesley Bell-Sakyi, Ana M. Palomar, Emma L. Bradford, Varda Shkap -
Large divergence and low diversity suggest genetically informed conservation strategies for the endangered Virgin Islands Boa (Chilabothrus monensis)
Abstract The Virgin Islands boa (Chilabothrus monensis) was listed as critically endangered by the U.S. Fish and Wildlife Service in 1979, and is presently known to occur in two disjunct regions: Isla de Mona and the eastern Puerto Rico Bank....
2015 / R. Graham Reynolds, Alberto R. Puente-Rolón, Renata Platenberg, R. Kirsten Tyler, Peter J. Tolson, et al.