Biological sciences topic list of research papers
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Life Extension Factor Klotho Enhances Cognition
Summary Aging is the primary risk factor for cognitive decline, an emerging health threat to aging societies worldwide. Whether anti-aging factors such as klotho can counteract cognitive decline is unknown. We show that a lifespan-extending variant...
2014 / Dena B. Dubal, Jennifer S. Yokoyama, Lei Zhu, Lauren Broestl, Kurtresha Worden, et al. -
Fumarylacetoacetate hydrolase deficient pigs are a novel large animal model of metabolic liver disease
Abstract Hereditary tyrosinemia type I (HT1) is caused by deficiency in fumarylacetoacetate hydrolase (FAH), an enzyme that catalyzes the last step of tyrosine metabolism. The most severe form of the disease presents acutely during infancy, and is...
2014 / Raymond D. Hickey, Shennen A. Mao, Jaime Glorioso, Joseph B. Lillegard, James E. Fisher, et al. -
Argonaute2 Mediates Compensatory Expansion of the Pancreatic β Cell
Summary Pancreatic β cells adapt to compensate for increased metabolic demand during insulin resistance. Although the microRNA pathway has an essential role in β cell proliferation, the extent of its contribution is unclear. Here, we report that...
2013 / Sudhir G. Tattikota, Thomas Rathjen, Sarah J. McAnulty, Hans-Hermann Wessels, Ildem Akerman, et al. -
A clinicogenetic model to predict lymph node invasion by use of genome-based biomarkers from exome arrays in prostate cancer patients2015 / Jong Jin Oh, Seunghyun Park, Sang Eun Lee, Sung Kyu Hong, Sangchul Lee, et al.
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Delivery of crop pollination services is an insufficient argument for wild pollinator conservation2015 / David Kleijn, Rachael Winfree, Ignasi Bartomeus, Luísa G Carvalheiro, Mickaël Henry, et al.
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Methylmercury exposure during early Xenopus laevis development affects cell proliferation and death but not neural progenitor specification
Abstract Methylmercury (MeHg) is a widespread environmental toxin that preferentially and adversely affects developing organisms. To investigate the impact of MeHg toxicity on the formation of the vertebrate nervous system at physiologically...
2014 / Ryan W. Huyck, Maitreyi Nagarkar, Nina Olsen, Samuel E. Clamons, Margaret S. Saha -
The Evolution of the Ribosome and the Genetic Code2014 / Hyman Hartman, Temple Smith
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Oncogenic signaling in amphiregulin and EGFR-expressing PTEN-null human breast cancer
Abstract A subset of triple negative breast cancer (TNBC) is characterized by overexpression of the epidermal growth factor receptor (EGFR) and loss of PTEN, and patients with these determinants have a poor prognosis. We used cell line models of...
2014 / Christiana S. Kappler, Stephen T. Guest, Jonathan C. Irish, Elizabeth Garrett-Mayer, Zachary Kratche, et al. -
Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia2014 / Amanda B Spurdle, Fergus J Couch, Michael T Parsons, Lesley McGuffog, Daniel Barrowdale, et al.
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Hymenoptera. Chapter 122010 / Jean-Yves Rasplus, Claire Villemant, Maria Rosa Paiva, Gérard Delvare, Alain Roques
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Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.)2013 / Ray Ming, Robert VanBuren, Yanling Liu, Mei Yang, Yuepeng Han, et al.
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The Xenopus ORFeome: A resource that enables functional genomics
Abstract Functional characterisation of proteins and large-scale, systems-level studies are enabled by extensive sets of cloned open reading frames (ORFs) in an easily-accessible format that enables many different applications. Here we report the...
2015 / Ian M. Grant, Dawit Balcha, Tong Hao, Yun Shen, Prasad Trivedi, et al. -
Design questions for Streptococcus pneumoniae vaccine trials with a colonisation endpoint
Abstract Evaluation of vaccine efficacy for protection against colonisation (VE col ) with Streptococcus pneumoniae and other bacterial pathogens is often based on a cross-sectional...
2013 / Kari Auranen, Hanna Rinta-Kokko, David Goldblatt, Hanna Nohynek, Katherine L. O’Brien, et al. -
Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci
Genome-wide association studies (GWASs) have identified many SNPs underlying variations in plasma-lipid levels. We explore whether additional loci associated with plasma-lipid phenotypes, such as high-density lipoprotein cholesterol (HDL-C), low-density...
2012 / Folkert W. Asselbergs, Yiran Guo, Erik P.A. van Iperen, Suthesh Sivapalaratnam, Vinicius Tragante, et al. -
Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases2013 / B.E. Riley, J.C. Lougheed, K. Callaway, M. Velasquez, E. Brecht, et al.
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Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay
Abstract Background Warfarin directly inhibits vitamin K 2,3-epoxide reductase (VKOR) enzymes. Since the early 1970s, warfarin inhibition of vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), an essential enzyme for proper ...
2013 / Carville G. Bevans, Christoph Krettler, Christoph Reinhart, Hélène Tran, Katja Koßmann, et al. -
Amygdaloid Corticotropin-releasing Factor is Involved in the Anxiolytic Effect of Acupuncture during Ethanol Withdrawal in Rats
Abstract In a previous study, acupuncture at acupoint HT7 attenuated ethanol withdrawal-induced anxiety-like behavior in rats by normalizing amygdaloid catecholamines. In the present study, the involvement of amygdaloid corticotropin-releasing...
2013 / ZhengLin Zhao, XiuDong Jin, YiYan Wu, XuDong Yang, YanJi Xu, et al. -
Comparative analysis of harvesting machines on an operational high-density short rotation woody crop (SRWC) culture: One-process versus two-process harvest operation
Abstract Short rotation woody crops (SRWCs) are being studied and cultivated because of their potential for bioenergy production. The harvest operation represents the highest input cost for these short rotation woody crops. We evaluated three...
2013 / G. Berhongaray, O. El Kasmioui, R. Ceulemans -
Highly efficient generation of glutamatergic/cholinergic NT2-derived postmitotic human neurons by short-term treatment with the nucleoside analogue cytosine β-d-arabinofuranoside
Abstract The human NTERA2/D1 (NT2) cells generate postmitotic neurons (NT2N cells) upon retinoic acid (RA) treatment and are functionally integrated in the host tissue following grafting into the rodent and human brain, thus representing a promising ...
2016 / Imanol González-Burguera, Ana Ricobaraza, Xabier Aretxabala, Sergio Barrondo, Gontzal García del Caño, et al. -
The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity
Summary Lipid metabolism and receptor-mediated signaling are highly intertwined processes that cooperate to fulfill cellular functions and safeguard cellular homeostasis. Activation of Toll-like receptors (TLRs) leads to a complex cellular response, ...
2015 / Leonhard X. Heinz, Christoph L. Baumann, Marielle S. Köberlin, Berend Snijder, Riem Gawish, et al.