Biological sciences topic list of research papers
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Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer2011 / Ian P. M. Tomlinson, Luis G. Carvajal-Carmona, Sara E. Dobbins, Albert Tenesa, Angela M. Jones, et al.
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Naturalistic speeding data: Drivers aged 75 years and older
Abstract The data presented in this article are related to the research article entitled “A longitudinal investigation of the predictors of older drivers׳ speeding behavior” (Chevalier et al., 2016) [1], wherein these speed events were used to...
2016 / Anna Chevalier, Aran John Chevalier, Elizabeth Clarke, John Wall, Kristy Coxon, et al. -
Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1
Abstract Aims The present study is designed to consider a role for the circadian clock protein Per1 in the regulation of the endothelin axis in mouse kidney, lung, liver and heart. Renal endothelin-1 (ET-1) is a regulator of the...
2014 / Jacob Richards, Amanda K. Welch, Sarah J. Barilovits, Sean All, Kit-Yan Cheng, et al. -
High-precision correlative fluorescence and electron cryo microscopy using two independent alignment markers
Abstract Correlative light and electron microscopy (CLEM) is an emerging technique which combines functional information provided by fluorescence microscopy (FM) with the high-resolution structural information of electron microscopy (EM). So far,...
2013 / Pascale Schellenberger, Rainer Kaufmann, C. Alistair Siebert, Christoph Hagen, Harald Wodrich, et al. -
Immunogenicity of a recombinant measles HIV-1 subtype C vaccine
Abstract The HIV epidemic is greatest in Sub-Saharan Africa and India where HIV-1 subtype C is predominant. To control the spread of HIV in these parts of the world a preventive HIV-1 subtype C vaccine is urgently required. Here we report the...
2013 / Richard Stebbings, Bo Li, Clarisse Lorin, Marguerite Koutsoukos, Michèle Février, et al. -
Cell-permeant recombinant Nanog protein promotes pluripotency by inhibiting endodermal specification
Abstract A comprehensive understanding of the functional network of transcription factors establishing and maintaining pluripotency is key for the development of biomedical applications of stem cells. Nanog plays an important role in early...
2014 / Michael Peitz, Bernhard Münst, Rajkumar P. Thummer, Martina Helfen, Frank Edenhofer -
Characterization of tweety gene (ttyh1-3) expression in Xenopus laevis during embryonic development
Abstract The tweety family of genes encodes large-conductance chloride channels and has been implicated in a wide array of cellular processes including cell division, cell adhesion, regulation of calcium activity, and tumorigenesis, particularly in...
2014 / Andrew D. Halleran, Morgan Sehdev, Brian A. Rabe, Ryan W. Huyck, Cheyenne C. Williams, et al. -
Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics
Summary The panoply of microorganisms and other species present in our environment influence human health and disease, especially in cities, but have not been profiled with metagenomics at a city-wide scale. We sequenced DNA from surfaces across the ...
2015 / Ebrahim Afshinnekoo, Cem Meydan, Shanin Chowdhury, Dyala Jaroudi, Collin Boyer, et al. -
Rescue of gene-expression changes in an induced mouse model of spinal muscular atrophy by an antisense oligonucleotide that promotes inclusion of SMN2 exon 7
Abstract Spinal muscular atrophy (SMA) is a neuromuscular disease caused by disruption of the survival motor neuron 1 (SMN1) gene, partly compensated for by the paralogous gene SMN2. Exon 7 inclusion is critical for full-length SMN protein...
2015 / John F. Staropoli, Huo Li, Seung J. Chun, Norm Allaire, Patrick Cullen, et al. -
The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism2014 / Dexter Hadley, Zhi-liang Wu, Charlly Kao, Akshata Kini, Alisha Mohamed-Hadley, et al.
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Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure
Abstract Excessive acetaminophen (APAP) use is one of the most common causes of acute liver failure. Various types of cell death in the damaged liver are linked to APAP-induced hepatotoxicity, and, of these, necrotic cell death of hepatocytes has...
2014 / Kenji Takemoto, Etsuro Hatano, Keiko Iwaisako, Masatoshi Takeiri, Naruto Noma, et al. -
Homeostasis of phospholipids — The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens
Abstract Ethanolamine plasmalogens constitute a group of ether glycerophospholipids that, due to their unique biophysical and biochemical properties, are essential components of mammalian cellular membranes. Their importance is emphasized by the...
2014 / Fabian Dorninger, Alexander Brodde, Nancy E. Braverman, Ann B. Moser, Wilhelm W. Just, et al. -
Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach2009 / Dimitrios Paraskevis, Oliver Pybus, Gkikas Magiorkinis, Angelos Hatzakis, Annemarie MJ Wensing, et al.
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Antigenicity and immunogenicity of a novel chimeric peptide antigen based on the P. vivax circumsporozoite protein
Abstract Background Plasmodium vivax circumsporozoite (PvCS) protein is a major sporozoite surface antigen involved in parasite invasion of hepatocytes and is currently being considered as vaccine candidate....
2013 / Nora Céspedes, Myriam Arévalo-Herrera, Ingrid Felger, Steve Reed, Andrey V. Kajava, et al. -
The role of skeletal micro-architecture in diagenesis and dating of Acropora palmata
Abstract Past variations in global sea-level reflect continental ice volume, a crucial factor for understanding the Earth’s climate system. The Caribbean coral Acropora palmata typically forms dense stands in very shallow water and therefore fossil...
2016 / P.J. Tomiak, M.B. Andersen, E.J. Hendy, E.K. Potter, K.G. Johnson, et al. -
Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor
Abstract Despite being one of the first antitubercular agents identified, isoniazid (INH) is still the most prescribed drug for prophylaxis and tuberculosis (TB) treatment and, together with rifampicin, the pillars of current chemotherapy. A high...
2016 / María Martínez-Hoyos, Esther Perez-Herran, Gulcin Gulten, Lourdes Encinas, Daniel Álvarez-Gómez, et al. -
The African Journal of Urology2013 / Chris Heyns
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Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice
Abstract Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling genes is linked to hearing status in the 1958 British Birth Cohort. This analysis implicated...
2013 / Lisa S. Nolan, Hannes Maier, Irm Hermans-Borgmeyer, Giorgia Girotto, Russell Ecob, et al. -
Predominance of interleukin-22 over interleukin-17 at the site of disease in human tuberculosis
Summary The inflammatory response to Mycobacterium tuberculosis (M.tb) at the site of disease is Th1 driven. Whether the Th17 cytokines, IL-17 and IL-22, contribute to this response in humans is unknown. We hypothesized that IL-17 and IL-22...
2011 / Kerryn Matthews, Katalin A. Wilkinson, Barbara Kalsdorf, Teri Roberts, Andreas Diacon, et al. -
GATA2 zinc finger 2 mutation found in acute myeloid leukemia impairs myeloid differentiation
Abstract We identified two novel GATA2 mutations in acute myeloid leukemia (AML). One mutation (p.R308P-GATA2) was a R308P substitution within the zinc finger (ZF)-1 domain, and the other (p.A350_N351ins8-GATA2) was an eight-amino-acid insertion...
2013 / Keiko Niimi, Hitoshi Kiyoi, Yuichi Ishikawa, Fumihiko Hayakawa, Shingo Kurahashi, et al.