Biological sciences topic list of research papers
-
Rites of passage: requirements and standards for building kinetic models of metabolic phenotypes
The overarching ambition of kinetic metabolic modeling is to capture the dynamic behavior of metabolism to such an extent that systems and synthetic biology strategies can reliably be tested in silico. The lack of kinetic data hampers the development of kinetic...
2015 / Ljubisa Miskovic, Milenko Tokic, Georgios Fengos, Vassily Hatzimanikatis -
Spatial and memory circuits in the medial entorhinal cortex
The large capacity of episodic memory is thought to be supported by the emergence of distinct hippocampal cell assemblies for unrelated memories, such that interference is minimized. In large-scale population recordings, the orthogonal nature of hippocampal...
2014 / Takuya Sasaki, Stefan Leutgeb, Jill K Leutgeb -
Disequilibrium of BMP2 Levels in the Breast Stem Cell Niche Launches Epithelial Transformation by Overamplifying BMPR1B Cell Response
Summary Understanding the mechanisms of cancer initiation will help to prevent and manage the disease. At present, the role of the breast microenvironment in transformation remains unknown. As BMP2 and BMP4 are important regulators of stem cells and ...
2015 / Marion Chapellier, Elodie Bachelard-Cascales, Xenia Schmidt, Flora Clément, Isabelle Treilleux, et al. -
Two new species of Mycodrosophila (Diptera, Drosophilidae) proposed by molecular and morphological approaches, with a key to American species2015 / João Junges, Marco Silva Gottschalk, Elgion Lucio da Silva Loreto, Lizandra Jaqueline Robe
-
Allelic variation on DcAOX1 gene in carrot (Daucus carota L.): An interesting simple sequence repeat in a highly variable intron
Abstract The alternative oxidase (AOX) is a key enzyme of the alternative respiration pathway and is involved in plant response to a variety of environmental stresses. The genes encoding for this enzyme are highly polymorphic and thus likely good...
2015 / Amaia Nogales, Tânia Nobre, Helia G. Cardoso, Luz Muñoz-Sanhueza, Vera Valadas, et al. -
Complete Sequence of pABTJ2, A Plasmid from Acinetobacter baumannii MDR-TJ, Carrying Many Phage-like Elements
Abstract Acinetobacter baumannii is an important opportunistic pathogen in hospital, and the multidrug-resistant isolates of A. baumannii have been increasingly reported in recent years. A number of different mechanisms of...
2014 / He Huang, Yan Dong, Zhi-Liang Yang, Hao Luo, Xi Zhang, et al. -
A rapid field detection system for citrus huanglongbing associated ‘Candidatus Liberibacter asiaticus’ from the psyllid vector, Diaphorina citri Kuwayama and its implications in disease management
Abstract ‘Candidatus Liberibacter asiaticus’ (Las), associated with citrus huanglongbing (HLB or citrus greening) is spread by Diaphorina citri Kuwayama, the Asian citrus psyllid. Psyllids can be tested to assess the prevalence of Las in a...
2014 / Manjunath L. Keremane, Chandrika Ramadugu, Esteban Rodriguez, Ryo Kubota, Scott Shibata, et al. -
Classical and atypical agonists activate M1 muscarinic acetylcholine receptors through common mechanisms
Abstract We mutated key amino acids of the human variant of the M1 muscarinic receptor that target ligand binding, receptor activation, and receptor-G protein interaction. We compared the effects of these mutations on the action of two atypical M1...
2015 / Alena Randáková, Eva Dolejší, Vladimír Rudajev, Pavel Zimčík, Vladimír Doležal, et al. -
Comparative morphology of the reproductive system and germ cells of Amblyomma ticks (Acari: Ixodidae): A contribution to Ixodidae systematics
Abstract Among arthropods, ticks of the genus Amblyomma are of great medical and veterinary importance and present phylogenetic and taxonomic divergences given polymorphisms and phenotypic plasticity between subpopulations. Generally, the male...
2015 / B.R. Sampieri, J.C.S. Moreira, F.A.R. Páez, M.I. Camargo-Mathias -
Multicenter Analyses Demonstrate Significant Clinical Effects of Minor Histocompatibility Antigens on GvHD and GvL after HLA-Matched Related and Unrelated Hematopoietic Stem Cell Transplantation
Abstract The effect of minor H antigen mismatching on the occurrence of graft-versus-host disease (GvHD) and graft-versus-leukemia (GvL) after HLA-matched hematopoietic stem cell transplantation (HSCT) has mainly been demonstrated in single-center...
2013 / Eric Spierings, Yeung-Hyen Kim, Matthijs Hendriks, Eric Borst, Ruhena Sergeant, et al. -
Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis2013 / Tao Zhang, Wenjie Guo, Yang Yang, Wen Liu, Lele Guo, et al.
-
Prognostic Impact of Vitamin B6 Metabolism in Lung Cancer
Summary Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin responses...
2012 / Lorenzo Galluzzi, Ilio Vitale, Laura Senovilla, Ken André Olaussen, Guillaume Pinna, et al. -
The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All Cohorts2007 / Helen N. Lyon, Valur Emilsson, Anke Hinney, Iris M. Heid, Jessica Lasky-Su, et al.
-
Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD2010 / Nancy L. Saccone, Robert C. Culverhouse, Tae-Hwi Schwantes-An, Dale S. Cannon, Xiangning Chen, et al.
-
CDK-mediated activation of the SCF FBXO 28 ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer2013 / Diana Cepeda, Hwee-Fang Ng, Hamid Reza Sharifi, Salah Mahmoudi, Vanessa Soto Cerrato, et al.
-
VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects2013 / Christopher R. Heier, Jesse M. Damsker, Qing Yu, Blythe C. Dillingham, Tony Huynh, et al.
-
The tiger genome and comparative analysis with lion and snow leopard genomes2013 / Yun Sung Cho, Li Hu, Haolong Hou, Hang Lee, Jiaohui Xu, et al.
-
Complete genome sequence of Nitratifractor salsuginis type strain (E9I37-1T)2011 / Iain Anderson, Johannes Sikorski, Ahmet Zeytun, Matt Nolan, Alla Lapidus, et al.
-
Molecular detection of Toxoplasma gondii in water samples from Scotland and a comparison between the 529bp real-time PCR and ITS1 nested PCR
Abstract Waterborne transmission of Toxoplasma gondii is a potential public health risk and there are currently no agreed optimised methods for the recovery, processing and detection of T. gondii oocysts in water samples. In this study modified...
2015 / Beth Wells, Hannah Shaw, Giles Innocent, Stefano Guido, Emily Hotchkiss, et al. -
A co-culture model of the hippocampal neurogenic niche reveals differential effects of astrocytes, endothelial cells and pericytes on proliferation and differentiation of adult murine precursor cells
Abstract The niche concept of stem cell biology proposes a functional unit between the precursor cells and their local microenvironment, to which several cell types might contribute by cell–cell contacts, extracellular matrix, and humoral factors....
2015 / Fanny Ehret, Steffen Vogler, Gerd Kempermann