Biological sciences topic list of research papers
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MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1
Abstract Deregulated microRNAs and their roles in cancer development have attracted much attention. Although miR-133a has been shown to be important in osteogenesis, its roles in osteosarcoma carcinogenesis and progression remain unknown. Hence, we...
2013 / Fang Ji, Hao Zhang, Yang Wang, Ming Li, Weidong Xu, et al. -
Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment
Abstract Introduction Unwanted drug interactions with ionic currents in the heart can lead to an increased pro-arrhythmic risk to patients in the clinic. It is therefore a priority for safety pharmacology teams to detect block of...
2013 / Ryan C. Elkins, Mark R. Davies, Stephen J. Brough, David J. Gavaghan, Yi Cui, et al. -
Cetacean abundance and distribution in European Atlantic shelf waters to inform conservation and management
Abstract The European Union (EU) Habitats Directive requires Member States to monitor and maintain at favourable conservation status those species identified to be in need of protection, including all cetaceans. In July 2005 we surveyed the entire...
2013 / Philip S. Hammond, Kelly Macleod, Per Berggren, David L. Borchers, Louise Burt, et al. -
Synthesis of Xylooligosaccharides of Daidzein and Their Anti-Oxidant and Anti-Allergic Activities2011 / Kei Shimoda, Hiroki Hamada, Hatsuyuki Hamada
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Sialic acid-binding Ig-like lectin-7 interacts with HIV-1 gp120 and facilitates infection of CD4pos T cells and macrophages2013 / Stefania Varchetta, Paolo Lusso, Kelly Hudspeth, Joanna Mikulak, Dalila Mele, et al.
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Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain2014 / Daniel Ursu, Philip Ebert, Emily Langron, Cara Ruble, Leanne Munsie, et al.
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A 22-single nucleotide polymorphism Alzheimer risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42
Abstract Introduction The ability to identify individuals at increased genetic risk for Alzheimer's disease (AD) may streamline biomarker and drug trials and aid clinical and personal decision making. ...
2015 / Kristel Sleegers, Karolien Bettens, Arne De Roeck, Caroline Van Cauwenberghe, Elise Cuyvers, et al. -
Transthyretin chemical chaperoning by flavonoids: Structure–activity insights towards the design of potent amyloidosis inhibitors
Abstract Background Many polyphenols have been proposed as broad-spectrum inhibitors of amyloid formation. To investigate structure–activity relationships relevant for the interaction of flavonoids with transthyretin (TTR), the...
2015 / Nelson Ferreira, Alda Pereira-Henriques, Maria Rosário Almeida -
Disentangling host, pathogen, and environmental determinants of a recently emerged wildlife disease: lessons from the first 15 years of amphibian chytridiomycosis research2015 / Timothy Y. James, L. Felipe Toledo, Dennis Rödder, Domingos da Silva Leite, Anat M. Belasen, et al.
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Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury
Abstract The mechanism by which c-Jun N-terminal protein kinase (JNK) promotes tissue injury is poorly understood. Thus we aimed at studying the roles of JNK and its phospho-target proteins in mouse models of acute liver injury. Young male mice were ...
2015 / Sehwan Jang, Li-Rong Yu, Mohamed A. Abdelmegeed, Yuan Gao, Atrayee Banerjee, et al. -
P-glycoprotein is expressed and causes resistance to chemotherapy in EBV-positive T-cell lymphoproliferative diseases2015 / Mayumi Yoshimori, Honami Takada, Ken-Ichi Imadome, Morito Kurata, Kouhei Yamamoto, et al.
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Vibrio spp. from Macrobrachium amazonicum prawn farming are inhibited by Moringa oleifera extracts
Abstract Objective To investigate the in vitro antimicrobial potential of extracts of stem, leaves, flowers, pods and seeds of Moringa oleifera (M. oleifera) against Vibrio spp. from hatchery water and the prawn Macrobrachium...
2015 / Raimunda Sâmia Nogueira Brilhante, Jamille Alencar Sales, Celia Maria de Souza Sampaio, Francisco Geraldo Barbosa, Manoel de Araújo Neto Paiva, et al. -
Mitochondrial targeting increases specific activity of a heterologous valine assimilation pathway in Saccharomyces cerevisiae
Abstract Bio-based isobutantol is a sustainable ‘drop in’ substitute for petroleum-based fuels. However, well-studied production routes, such as the Ehrlich pathway, have yet to be commercialized despite more than a century of research. The more...
2016 / Kevin V. Solomon, Elisa Ovadia, Fujio Yu, Wataru Mizunashi, Michelle A. O’Malley -
Current Awareness on Comparative and Functional Genomics2002 /
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Brain Activity and Tinnitus2005 /
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beta-Naphthoflavone protects from peritonitis by reducing TNF-alpha-induced endothelial cell activation
Abstract β-Naphthoflavone (β-NF), a ligand of the aryl hydrocarbon receptor, has been shown to possess anti-oxidative properties. We investigated the anti-oxidative and anti-inflammatory potential of β-NF in human microvascular endothelial cells...
2015 / Sheng-Yao Hsu, Je-Wen Liou, Tsung-Lin Cheng, Shih-Yi Peng, Chi-Chen Lin, et al. -
Data in support of the comparative genome analysis of Lysinibacillus B1-CDA, a bacterium that accumulates arsenics
Abstract This study is a part of our long term project on bioremediation of toxic metals and other pollutants for protection of human health and the environment from severe contamination. The information and results presented in this data article...
2015 / Aminur Rahman, Noor Nahar, Neelu N. Nawani, Jana Jass, Sibdas Ghosh, et al. -
Improving the flux distributions simulated with genome-scale metabolic models of Saccharomyces cerevisiae
Abstract Genome-scale metabolic models (GEMs) can be used to evaluate genotype-phenotype relationships and their application to microbial strain engineering is increasing in popularity. Some of the algorithms used to simulate the phenotypes of...
2016 / Rui Pereira, Jens Nielsen, Isabel Rocha -
Schistosoma mansoni in schoolchildren in a Madagascan highland school assessed by PCR and sedimentation microscopy and Bayesian estimation of sensitivities and specificities
Abstract Madagascar is an endemic area for schistosomiasis, but recent prevalence data are scarce. We investigated stool samples of 410 children aged 4–18 years from a combined primary and secondary school in a Madagascan highland village near...
2014 / Norbert G. Schwarz, Raphael Rakotozandrindrainy, Jean N. Heriniaina, Njary Randriamampionona, Andreas Hahn, et al. -
Analysis of Transcription Factors Key for Mouse Pancreatic Development Establishes NKX2-2 and MNX1 Mutations as Causes of Neonatal Diabetes in Man
Summary Understanding transcriptional regulation of pancreatic development is required to advance current efforts in developing beta cell replacement therapies for patients with diabetes. Current knowledge of key transcriptional regulators has...
2014 / Sarah E. Flanagan, Elisa De Franco, Hana Lango Allen, Michele Zerah, Majedah M. Abdul-Rasoul, et al.