Biological sciences topic list of research papers
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The tetramethoxyflavone zapotin selectively activates protein kinase C epsilon, leading to its down-modulation accompanied by Bcl-2, c-Jun and c-Fos decrease
Abstract Zapotin, a tetramethoxyflavone, is a natural compound with a wide spectrum of activities in neoplastic cells. Protein kinase C epsilon (PKCε) has been shown to be oncogenic, with the ability to increase cell migration, invasion and survival ...
2012 / Ewa Toton, Natalia Lisiak, Blazej Rubis, Jaromir Budzianowski, Peter Gruber, et al. -
Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse2013 / Seung Hwa Hong, Rohyun Sung, Young Chul Kim, Hikaru Suzuki, Woong Choi, et al.
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Cdk5 contributes to inflammation-induced thermal hyperalgesia mediated by the p38 MAPK pathway in microglia
Abstract Background: The mechanisms underlying cyclin-dependent kinase 5 (Cdk5)-mediated thermal hyperalgesia induced by inflammation remain poorly understood. In the present study, we examined thermal hyperalgesia provoked by...
2015 / Fang-Hu, Hong-Hai Zhang, Bin-Xia Yang, Jin-Lu Huang, Jian-Liang Shun, et al. -
Complement inhibitor CD55 governs the integrity of membrane rafts in pancreatic beta cells, but plays no role in insulin secretion
Abstract CD55 is a glycosylphosphatidylinositol-anchored protein, which inhibits complement activation by acting on the complement C3 convertases. CD55 is widely localized in the cholesterol rich regions of the cell plasma membrane termed membrane...
2015 / Vini Nagaraj, Ben King, Petter Storm, Petter Vikman, Emilia Ottosson-Laakso, et al. -
Methamphetamine decreases dentate gyrus stem cell self-renewal and shifts the differentiation towards neuronal fate
Abstract Methamphetamine (METH) is a highly addictive psychostimulant drug of abuse that negatively interferes with neurogenesis. In fact, we have previously shown that METH triggers stem/progenitor cell death and decreases neuronal differentiation...
2014 / Sofia Baptista, Charlène Lasgi, Caroline Benstaali, Nuno Milhazes, Fernanda Borges, et al. -
Ubiquitin control of S phase: a new role for the ubiquitin conjugating enzyme, UbcH72009 / Elizabeth A Whitcomb, Allen Taylor
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A Mycobacterium tuberculosis Dormancy Antigen Differentiates Latently Infected Bacillus Calmette–Guérin-vaccinated Individuals
Abstract IFN-γ release assays (IGRAs) are better indicators of Mycobacterium tuberculosis infection than the tuberculin skin test (TST) in Bacillus Calmette–Guérin (BCG)-vaccinated populations. However, IGRAs do not discriminate active and latent...
2015 / Delfina Peña, Ana I. Rovetta, Rodrigo E. Hernández Del Pino, Nicolás O. Amiano, Virginia Pasquinelli, et al. -
The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system
Abstract Devices implanted into the body become encapsulated due to a foreign body reaction. In the central nervous system (CNS), this can lead to loss of functionality in electrodes used to treat disorders. Around CNS implants, glial cells are...
2014 / Pouria Moshayedi, Gilbert Ng, Jessica C.F. Kwok, Giles S.H. Yeo, Clare E. Bryant, et al. -
A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease
Abstract Background Conflicting evidence exists on whether smoking acts as an effect modifier of the association between APOE genotype and risk of coronary heart disease (CHD). ...
2014 / Michael V. Holmes, Ruth Frikke-Schmidt, Daniela Melis, Robert Luben, Folkert W. Asselbergs, et al. -
CD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells
Abstract Intercellular communication is critical for integrating complex signals in multicellular eukaryotes. Vascular endothelial cells and T lymphocytes closely interact during the recirculation and trans-endothelial migration of T cells. In...
2014 / Sukhbir Kaur, Satya P. Singh, Abdel G. Elkahloun, Weiwei Wu, Mones S. Abu-Asab, et al. -
Real-time trafficking and signaling of the glucagon-like peptide-1 receptor
Abstract The glucagon-like peptide-1 incretin receptor (GLP-1R) of family B G protein-coupled receptors (GPCRs) is a major drug target in type-2-diabetes due to its regulatory effect on post-prandial blood-glucose levels. The mechanism(s)...
2013 / Sarah Noerklit Roed, Pernille Wismann, Christina Rye Underwood, Nikolaj Kulahin, Helle Iversen, et al. -
Clade-specific impacts of human land use on primates
Abstract Here we applied phylogenetically based conservation analyses using a novel multivariate approach to better evaluate the effects of human land use on different primate lineages worldwide. Using a 1°×1° grid, we obtained information on...
2014 / Fernanda T. Brum, Vanderlei J. Debastiani, Rafael Loyola, Leandro D.S. Duarte -
Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia
Abstract Epsilon toxin (Etx) is a β-pore-forming toxin produced by Clostridium perfringens toxinotypes B and D and plays a key role in the pathogenesis of enterotoxemia, a severe, often fatal disease of ruminants that causes significant economic...
2014 / Monika Bokori-Brown, Charlotte A. Hall, Charlotte Vance, Sérgio P. Fernandes da Costa, Christos G. Savva, et al. -
Dystrophin-deficient cardiomyocytes derived from human urine: New biologic reagents for drug discovery
Abstract The ability to extract somatic cells from a patient and reprogram them to pluripotency opens up new possibilities for personalized medicine. Induced pluripotent stem cells (iPSCs) have been employed to generate beating cardiomyocytes from a ...
2013 / Xuan Guan, David L. Mack, Claudia M. Moreno, Jennifer L. Strande, Julie Mathieu, et al. -
Functional characterization of a tyrosinase gene from the oomycete Saprolegnia parasitica by RNAi silencing
Abstract Here we describe the first application of transient gene silencing in Saprolegnia parasitica, a pathogenic oomycete that infects a wide range of fish, amphibians, and crustaceans. A gene encoding a putative tyrosinase from S. parasitica,...
2014 / Marcia Saraiva, Irene de Bruijn, Laura Grenville-Briggs, Debbie McLaggan, Ariane Willems, et al. -
Alterations in the heart rate and activity rhythms of three orbital astronauts on a space mission
Abstract Environmental factors in space are dramatically different from those on Earth. The spaceflight environment has been known to influence human physiology and behavior on orbital missions. In this study, we investigated alterations in the...
2015 / Zhizhen Liu, Yufeng Wan, Lin Zhang, Yu Tian, Ke Lv, et al. -
iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease
Summary Parkinson’s disease (PD) has been attributed to a combination of genetic and nongenetic factors. We studied a set of monozygotic twins harboring the heterozygous glucocerebrosidase mutation (GBA N370S) but clinically discordant for PD. We...
2014 / Chris M. Woodard, Brian A. Campos, Sheng-Han Kuo, Melissa J. Nirenberg, Michael W. Nestor, et al. -
A small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model
Abstract The p75 neurotrophin receptor (p75NTR) is associated with multiple mechanisms linked to Alzheimer's disease (AD); hence, modulating its function might confer therapeutic effects. In previous in vitro work, we developed small molecule p75NTR ...
2013 / Juliet K. Knowles, Danielle A. Simmons, Thuy-Vi V. Nguyen, Lilith Vander Griend, Youmei Xie, et al. -
Ultrastructural characterisation of Bacillus subtilis TatA complexes suggests they are too small to form homooligomeric translocation pores
Abstract Tat-dependent protein transport permits the traffic of fully folded proteins across membranes in bacteria and chloroplasts. The mechanism by which this occurs is not understood. Current theories propose that a key step requires the...
2013 / Daniel Beck, Nishi Vasisht, Jacopo Baglieri, Carmine G. Monteferrante, Jan Maarten van Dijl, et al. -
Blood Pressure Loci Identified with a Gene-Centric Array
Raised blood pressure (BP) is a major risk factor for cardiovascular disease. Previous studies have identified 47 distinct genetic variants robustly associated with BP, but collectively these explain only a few percent of the heritability for BP phenotypes. To...
2011 / Toby Johnson, Tom R. Gaunt, Stephen J. Newhouse, Sandosh Padmanabhan, Maciej Tomaszewski, et al.