Biological sciences topic list of research papers
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Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A
Abstract Objective Glucagon-like peptide 1 (GLP-1) enhances insulin secretion and protects β-cell mass. Diabetes therapies targeting the GLP-1 receptor (GLP-1R), expressed in numerous tissues, have diminished dose-response in...
2015 / Sindhu Rajan, Lorna M. Dickson, Elizabeth Mathew, Caitlin M.O. Orr, Johanne H. Ellenbroek, et al. -
Truncated HSPB1 causes axonal neuropathy and impairs tolerance to unfolded protein stress
Abstract Background HSPB1 belongs to the family of small heat shock proteins (sHSP) that have importance in protection against unfolded protein stress, in cancer cells for escaping drug toxicity stress and in neurons for...
2015 / Emil Ylikallio, Svetlana Konovalova, Yogesh Dhungana, Taru Hilander, Nella Junna, et al. -
Marek׳s disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway
Abstract Marek׳s disease virus (MDV) is a representative alpha herpes virus able to induce rapid-onset T-cell lymphoma in its natural host and regarded as an ideal model for the study of virus-induced tumorigenesis. Recent studies have shown that...
2014 / Jia-Qi Chi, Man Teng, Zu-Hua Yu, Hui Xu, Jing-Wei Su, et al. -
Evolution of Posidonia oceanica seagrass meadows and its implications for management
Abstract Results of the monitoring network of the Posidonia oceanica meadows in the Valencia region in Spain are analysed. For spatial comparison the whole data set has been analysed, however, for temporal trends we only selected stations that have...
2013 / Juan Eduardo Guillén, José Luis Sánchez Lizaso, Santiago Jiménez, Joaquín Martínez, Ana Codina, et al. -
Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction
Abstract Although the Nrf2 (nuclear factor-erythroid 2 p45 subunit-related factor 2) regulated expression of multiple antioxidant and cytoprotective genes through the electrophile responsive element (EpRE) is well established, interaction of...
2013 / Nikolai L. Chepelev, Hongqiao Zhang, Honglei Liu, Skye McBride, Andrew J. Seal, et al. -
Feeder-independent derivation of induced-pluripotent stem cells from peripheral blood endothelial progenitor cells
Abstract Induced-pluripotent stem cells (iPSCs) are a potential alternative cell source in regenerative medicine, which includes the use of differentiated iPSCs for cell therapies to treat coronary artery and/or peripheral arterial diseases....
2012 / Wing Y. Chang, Jessie R. Lavoie, Sarah Y. Kwon, Zhaoyi Chen, Janet L. Manias, et al. -
Triplex intermediates in folding of human telomeric quadruplexes probed by microsecond-scale molecular dynamics simulations
Abstract We have carried out extended set of μs-scale explicit solvent MD simulations of all possible G-triplexes which can participate in folding pathways of the human telomeric quadruplex. Our study accumulates almost 60 μs of simulation data,...
2014 / Petr Stadlbauer, Lukáš Trantírek, Thomas E. Cheatham, Jaroslav Koča, Jiří Šponer -
Nycteria parasites of Afrotropical insectivorous bats
Abstract Parasitic protozoan parasites have evolved many co-evolutionary paths towards stable transmission to their host population. Plasmodium spp., the causative agents of malaria, and related haemosporidian parasites are dipteran-borne eukaryotic ...
2015 / Juliane Schaer, DeeAnn M. Reeder, Megan E. Vodzak, Kevin J. Olival, Natalie Weber, et al. -
Phase II, randomized, open, controlled study of AS03-adjuvanted H5N1 pre-pandemic influenza vaccine in children aged 3 to 9 years: follow-up of safety and immunogenicity persistence at 24 months post-vaccination2015 / Javier Díez-Domingo, José-María Baldó, Maria Victoria Planelles-Catarino, María Garcés-Sánchez, Isabel Ubeda, et al.
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High yielding biomass genotypes of willow (Salix spp.) show differences in below ground biomass allocation
Abstract Willows (Salix spp.) grown as short rotation coppice (SRC) are viewed as a sustainable source of biomass with a positive greenhouse gas (GHG) balance due to their potential to fix and accumulate carbon (C) below ground. However, exploiting...
2015 / Jennifer Cunniff, Sarah J. Purdy, Tim J.P. Barraclough, March Castle, Anne L. Maddison, et al. -
TAILS N-terminomic and proteomic datasets of healthy human dental pulp
Abstract The Data described here provide the in depth proteomic assessment of the human dental pulp proteome and N-terminome (Eckhard et al., 2015) [1]. A total of 9 human dental pulps were processed and analyzed by the positional proteomics...
2015 / Ulrich Eckhard, Giada Marino, Simon R. Abbey, Ian Matthew, Christopher M. Overall -
Viewing Transplantation Immunology Through Today's Lens: New Models, New Imaging, and New Insights2012 / Alex Y. Huang, W. Nicholas Haining, Deborah S. Barkauskas, Jay T. Myers, Agne Petrosiute, et al.
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Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans
Abstract Homologous recombination (HR) is essential for maintaining genomic integrity, which is challenged by a wide variety of potentially lethal DNA lesions. Regardless of the damage type, recombination is known to proceed by RAD51-mediated D-loop ...
2013 / Marek Sebesta, Peter Burkovics, Szilvia Juhasz, Sufang Zhang, Judit E. Szabo, et al. -
Foxp3-expressing CD4+T Cells Under the Control of IFN-γ Promoter Prevent Diabetes in NOD Mice2007 / Renxi Wang, Gencheng Han, Jianan Wang, Lun Song, Guojiang Chen, et al.
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The secretome of apoptotic human peripheral blood mononuclear cells attenuates secondary damage following spinal cord injury in rats
Abstract After spinal cord injury (SCI), secondary damage caused by oxidative stress, inflammation, and ischemia leads to neurological deterioration. In recent years, therapeutic approaches to trauma have focused on modulating this secondary...
2015 / Thomas Haider, Romana Höftberger, Beate Rüger, Michael Mildner, Roland Blumer, et al. -
Standard of hygiene and immune adaptation in newborn infants
Abstract The prevalence of immune-mediated diseases, such as allergies and type 1 diabetes, is on the rise in the developed world. In order to explore differences in the gene expression patterns induced in utero in infants born in contrasting...
2014 / Henna Kallionpää, Essi Laajala, Viveka Öling, Taina Härkönen, Vallo Tillmann, et al. -
Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing
The DNA damage response (DDR) orchestrates DNA repair and halts cell cycle. If damage is not resolved, cells can enter into an irreversible state of proliferative arrest called cellular senescence. Organismal ageing in mammals is associated with accumulation of...
2014 / Francesca Rossiello, Utz Herbig, Maria Pia Longhese, Marzia Fumagalli, Fabrizio d’Adda di Fagagna -
Functional alpha7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus
Abstract Neurogenesis occurs throughout life in the subgranular zone of the dentate gyrus, and postnatal-born granule cells migrate into the granule cell layer and extend axons to their target areas. The α7⁎nicotinic receptor has been implicated in...
2014 / Danielle John, Irina Shelukhina, Yuchio Yanagawa, Jim Deuchars, Zaineb Henderson -
Antifibrogenic Effects of the Antimicrobial Peptide Cathelicidin in Murine Colitis-Associated Fibrosis
Background & Aims Cathelicidin (LL-37 in human and mCRAMP in mice) represents a family of endogenous antimicrobial peptides with anti-inflammatory effects. LL-37 also suppresses collagen synthesis, an important fibrotic response, in dermal...
2014 / Jun Hwan Yoo, Samantha Ho, Deanna Hoang-Yen Tran, Michelle Cheng, Kyriaki Bakirtzi, et al. -
Cognitive dysfunction and amyloid β accumulation are ameliorated by the ingestion of green soybean extract in aged mice
Abstract The effects of soybean extracts were investigated in senescence-accelerated (SAMP10) mice, a mouse model of brain senescence with cognitive dysfunction. Mature soybeans are usually yellow. However, the green soybean retains green color...
2015 / Keiko Unno, Tomokazu Konishi, Aimi Nakagawa, Yoshie Narita, Fumiyo Takabayashi, et al.