Biological sciences topic list of research papers
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Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation
Abstract Alternaria alternata is a fungal allergen linked to the development of severe asthma in humans. In view of the clinical relationship between A. alternata and asthma, we sought to investigate the allergic activity of...
2014 / Malgorzata A. Gil, Michael Caniga, Janice D. Woodhouse, Joseph Eckman, Hyun-Hee Lee, et al. -
The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome
Abstract Atypical hemolytic uremic syndrome (aHUS) associates with complement dysregulation caused by mutations and polymorphisms in complement activators and regulators. However, the reasons why some mutations in complement proteins predispose to...
2015 / Rubén Martínez-Barricarte, Meike Heurich, Andrés López-Perrote, Agustin Tortajada, Sheila Pinto, et al. -
CD109 attenuates TGF-β1 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells
Abstract CD109 is a glycosylphosphatidylinositol-anchored cell surface protein that is frequently detected in squamous cell carcinomas. CD109 is a negative regulator of TGF-β1 signaling in human keratinocytes, and the N-terminal fragment of CD109...
2015 / Jing-Min Zhang, Yoshiki Murakumo, Sumitaka Hagiwara, Ping Jiang, Shinji Mii, et al. -
Controlled delivery of a metabolic modulator promotes regulatory T cells and restrains autoimmunity
Abstract Autoimmune disorders occur when the immune system abnormally recognizes and attacks self-molecules. Dendritic cells (DCs) play a powerful role in initiating adaptive immune response, and are therefore a recent target for autoimmune...
2015 / Joshua M. Gammon, Lisa H. Tostanoski, Arjun R. Adapa, Yu-Chieh Chiu, Christopher M. Jewell -
Identification of differentially expressed genes between developing seeds of different soybean cultivars
Abstract Soybean is a major source of protein and oil and a primary feedstock for biodiesel production. Research on soybean seed composition and yield has revealed that protein, oil and yield are controlled quantitatively and quantitative trait loci ...
2015 / Rongshuang Lin, Jane Glazebrook, Fumiaki Katagiri, James H. Orf, Susan I. Gibson -
Assessing the structure and temporal dynamics of seabird communities: the challenge of capturing marine ecosystem complexity2015 / Rocío Moreno, Gabriele Stowasser, Rona A. R. McGill, Stuart Bearhop, Richard A. Phillips
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Sequencing of 15 622 gene-bearing BACs clarifies the gene-dense regions of the barley genome2015 / María Muñoz-Amatriaín, Stefano Lonardi, MingCheng Luo, Kavitha Madishetty, Jan T. Svensson, et al.
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Seasonal population abundance of the assembly of solitary wasps and bees (Hymenoptera) according to land-use in Maranhão state, Brazil2016 / Michela Costa Batista Matos, Shênia Santos Silva, Adenir Vieira Teodoro
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Identification of Important Sea Turtle Areas (ITAs) for hawksbill turtles in the Arabian Region
Abstract We present the first data on hawksbill turtle post-nesting migrations and behaviour in the Arabian region. Tracks from 90 post-nesting turtles (65 in the Gulf and 25 from Oman) revealed that hawksbills in the Arabian region may nest up to 6 ...
2014 / Nicolas J. Pilcher, Marina Antonopoulou, Lisa Perry, Mohamed A. Abdel-Moati, Thabit Zahran Al Abdessalaam, et al. -
Dysregulated Expression of Neuregulin-1 by Cortical Pyramidal Neurons Disrupts Synaptic Plasticity
Summary Neuregulin-1 (NRG1) gene variants are associated with increased genetic risk for schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased expression of NRG1 in the brains of schizophrenia...
2014 / Amit Agarwal, Mingyue Zhang, Irina Trembak-Duff, Tilmann Unterbarnscheidt, Konstantin Radyushkin, et al. -
5-Chloro-2-nitrobenzaldehyde isonicotinoylhydrazone: a three-dimensional framework built from N—H...N and C—H...O hydrogen bonds2006 / Solange M. S. V. Wardell, Marcus V. N. de Souza, James L. Wardell, John N. Low, Christopher Glidewell
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Dissecting the transcriptional phenotype of ribosomal protein deficiency: implications for Diamond-Blackfan Anemia
Abstract Defects in genes encoding ribosomal proteins cause Diamond Blackfan Anemia (DBA), a red cell aplasia often associated with physical abnormalities. Other bone marrow failure syndromes have been attributed to defects in ribosomal components...
2014 / Anna Aspesi, Elisa Pavesi, Elisa Robotti, Rossella Crescitelli, Ilenia Boria, et al. -
Cultivating resilience by empirically revealing response diversity
Abstract Intensified climate and market turbulence requires resilience to a multitude of changes. Diversity reduces the sensitivity to disturbance and fosters the capacity to adapt to various future scenarios. What really matters is diversity of...
2014 / Helena Kahiluoto, Janne Kaseva, Kaija Hakala, Sari J. Himanen, Lauri Jauhiainen, et al. -
RAF and antioxidants prevent cell death induction after growth factor abrogation through regulation of Bcl-2 proteins
Abstract We have shown previously that mitochondrial ROS production is essential to turn growth factor (GF) removal into cell death. Activated RAF, AKT, Bcl-2 and antioxidants protected equally well against ROS accumulation and subsequent death....
2013 / Katarzyna Koziel, Julija Smigelskaite, Astrid Drasche, Marion Enthammer, Muhammad Imtiaz Ashraf, et al. -
A novel activation-induced cytidine deaminase (AID) mutation in Brazilian patients with hyper-IgM type 2 syndrome
Abstract Activation-induced cytidine deaminase (AID) is a DNA editing protein that plays an essential role in three major events of immunoglobulin (Ig) diversification: somatic hypermutation, class switch recombination and Ig gene conversion....
2013 / Nadine Caratão, Catarina S. Cortesão, Pedro H. Reis, Raquel F. Freitas, Cristina M.A. Jacob, et al. -
Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons. Single-nucleotide polymorphism rs3849942 is associated with ALS, tagging a hexanucleotide repeat mutation in the C9orf72 gene. It is possible that there is ...
2013 / Ashley R. Jones, Ione Woollacott, Aleksey Shatunov, Johnathan Cooper-Knock, Vladimir Buchman, et al. -
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition
Abstract Genomic instability can initiate cancer, augment progression, and influence the overall prognosis of the affected patient. Genomic instability arises from many different pathways, such as telomere damage, centrosome amplification,...
2015 / Lynnette R. Ferguson, Helen Chen, Andrew R. Collins, Marisa Connell, Giovanna Damia, et al. -
A peptide affinity reagent for isolating an intact and catalytically active multi-protein complex from mammalian cells
Abstract We have developed an approach for directly isolating an intact multi-protein chromatin remodeling complex from mammalian cell extracts using synthetic peptide affinity reagent 4. FOG1(1–15), a short peptide sequence known to target subunits ...
2015 / Hinnerk Saathoff, Mattias Brofelth, Anne Trinh, Benjamin L. Parker, Daniel P. Ryan, et al. -
Pathway-based Analysis Tools for Complex Diseases: A Review
Abstract Genetic studies are traditionally based on single-gene analysis. The use of these analyses can pose tremendous challenges for elucidating complicated genetic interplays involved in complex human diseases. Modern pathway-based analysis...
2014 / Lv Jin, Xiao-Yu Zuo, Wei-Yang Su, Xiao-Lei Zhao, Man-Qiong Yuan, et al. -
The relationship of leaf photosynthetic traits - V cmax and J max - to leaf nitrogen, leaf phosphorus, and specific leaf area: a meta-analysis and modeling study2014 / Anthony P. Walker, Andrew P. Beckerman, Lianhong Gu, Jens Kattge, Lucas A. Cernusak, et al.