Biological sciences topic list of research papers
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High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene
Abstract Objective Association between prostate cancer and obesity remains controversial. Allelic deletions of PTEN, a tumor suppressor gene, are common in prostate cancer in men. Monoallelic Pten deletion in mice causes low...
2015 / Jehnan Liu, Sadeesh K. Ramakrishnan, Saja S. Khuder, Meenakshi K. Kaw, Harrison T. Muturi, et al. -
Anti-endotoxic and antibacterial effects of a dermal substitute coated with host defense peptides
Abstract Biomaterials used during surgery and wound treatment are of increasing importance in modern medical care. In the present study we set out to evaluate the addition of thrombin-derived host defense peptides to human acellular dermis (hAD,...
2015 / Gopinath Kasetty, Martina Kalle, Matthias Mörgelin, Jan C. Brune, Artur Schmidtchen -
Sugarcane trash levels in soil affects the fungi but not bacteria in a short-term field experiment2016 / C.T.C.C. Rachid, C.A. Pires, D.C.A. Leite, H.L.C. Coutinho, R.S. Peixoto, et al.
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Monitoring of Hematopoietic Chimerism after Transplantation for Pediatric Myelodysplastic Syndrome: Real-Time or Conventional Short Tandem Repeat PCR in Peripheral Blood or Bone Marrow?
Abstract Quantitative real-time PCR (qPCR) has been proposed as a highly sensitive method for monitoring hematopoietic chimerism and may serve as a surrogate marker for the detection of minimal residual disease minimal residual disease in...
2014 / Andre M. Willasch, Hermann Kreyenberg, Nona Shayegi, Eva Rettinger, Vida Meyer, et al. -
Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for Early-Onset Extreme Obesity in French and German Study Groups2010 / André Scherag, Christian Dina, Anke Hinney, Vincent Vatin, Susann Scherag, et al.
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Genome wide high density SNP-based linkage analysis of childhood absence epilepsy identifies a susceptibility locus on chromosome 3p23-p14
Summary Childhood absence epilepsy (CAE) is an idiopathic generalised epilepsy (IGE) characterised by typical absence seizures manifested by transitory loss of awareness with 2.5–4Hz spike-wave complexes on ictal EEG. A genetic component to the...
2009 / Barry A. Chioza, Jean Aicardi, Harald Aschauer, Oebele Brouwer, Petra Callenbach, et al. -
A Novel MMP12 Locus Is Associated with Large Artery Atherosclerotic Stroke Using a Genome-Wide Age-at-Onset Informed Approach2014 / Matthew Traylor, Kari-Matti Mäkelä, Laura L. Kilarski, Elizabeth G. Holliday, William J. Devan, et al.
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Distinct structural features of Rex-family repressors to sense redox levels in anaerobes and aerobes
Abstract The Rex-family repressors sense redox levels by alternative binding to NADH or NAD+. Unlike other Rex proteins that regulate aerobic respiration, RSP controls ethanol fermentation in the obligate anaerobe Thermoanaerobacter ethanolicus...
2014 / Yingying Zheng, Tzu-Ping Ko, Hong Sun, Chun-Hsiang Huang, Jianjun Pei, et al. -
Mutations in APOPT1, Encoding a Mitochondrial Protein, Cause Cavitating Leukoencephalopathy with Cytochrome c Oxidase Deficiency
Cytochrome c oxidase (COX) deficiency is a frequent biochemical abnormality in mitochondrial disorders, but a large fraction of cases remains genetically undetermined. Whole-exome sequencing led to the identification of APOPT1 mutations in two Italian sisters and...
2014 / Laura Melchionda, Tobias B. Haack, Steven Hardy, Truus E.M. Abbink, Erika Fernandez-Vizarra, et al. -
Distinct and Overlapping Sarcoma Subtypes Initiated from Muscle Stem and Progenitor Cells
Summary Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, whereas undifferentiated pleomorphic sarcoma (UPS) is one of the most common soft tissue sarcomas diagnosed in adults. To investigate the myogenic cell(s) of origin...
2013 / Jordan M. Blum, Leonor Añó, Zhizhong Li, David Van Mater, Brian D. Bennett, et al. -
Identification of pili on the surface of Finegoldia magna – A Gram-positive anaerobic cocci
Abstract Pili have only been discovered in the major Gram-positive pathogens in the past decade and they have been found to play an important role in colonisation and virulence. Pili have been shown to have many important functions including...
2014 / Elizabeth C. Murphy, Robert Janulczyk, Christofer Karlsson, Matthias Mörgelin, Inga-Maria Frick -
Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis
Summary Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H...
2014 / Isabelle K. Vila, Pierre-Marie Badin, Marie-Adeline Marques, Laurent Monbrun, Corinne Lefort, et al. -
Fluorescence kinetics of PSII crystals containing Ca2+ or Sr2+ in the oxygen evolving complex
Abstract Photosystem II (PSII) is the pigment–protein complex which converts sunlight energy into chemical energy by catalysing the process of light-driven oxidation of water into reducing equivalents in the form of protons and electrons....
2013 / Bart van Oort, Joanna Kargul, James Barber, Herbert van Amerongen -
Fine-Scale Mapping of the 5q11.2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1
Genome-wide association studies (GWASs) have revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt to identify the biologically relevant variants, we analyzed 909 genetic variants across 5q11.2 in...
2014 / Dylan M. Glubb, Mel J. Maranian, Kyriaki Michailidou, Karen A. Pooley, Kerstin B. Meyer, et al. -
Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes2005 / Kristina Allen-Brady, Nicola J Camp
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Identification of proteins inducing short-lived antibody responses from excreted/secretory products of Schistosoma japonicum adult worms by immunoproteomic analysis
Abstract The excretory/secretory antigens of Schistosoma japonicum (Sj ESAgs) play important roles in host–parasite immune interactions. In this study, the antibody response patterns to Sj ESAgs in sera of individual rabbits at the healthy stage,...
2013 / Jie Wang, Fei Zhao, Chuan-Xin Yu, Di Xiao, Li-Jun Song, et al. -
A Simple, Inexpensive, and Field-Relevant Microcosm Tidal Simulator for Use in Marsh Macrophyte Studies2014 / Rachel M. MacTavish, Risa A. Cohen
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Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry2013 / Shafqat Ahmad, Gull Rukh, Tibor V. Varga, Ashfaq Ali, Azra Kurbasic, et al.
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The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia2010 / Chao Agnes Hsiung, Qing Lan, Yun-Chul Hong, Chien-Jen Chen, H. Dean Hosgood, et al.
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Influence of Pichia pastoris cellular material on polymerase chain reaction performance as a synthetic biology standard for genome monitoring
Abstract Advances in synthetic genomics are now well underway in yeasts due to the low cost of synthetic DNA. These new capabilities also bring greater need for quantitating the presence, loss and rearrangement of loci within synthetic yeast...
2016 / Alexander Templar, Stefan Woodhouse, Eli Keshavarz-Moore, Darren N. Nesbeth