Biological sciences topic list of research papers
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Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths2009 / Marie Touchon, Claire Hoede, Olivier Tenaillon, Valérie Barbe, Simon Baeriswyl, et al.
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Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels2013 / Gian Andri Thun, Medea Imboden, Ilaria Ferrarotti, Ashish Kumar, Ma'en Obeidat, et al.
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Establishment of leukemia inhibitory factor (LIF)-independent iPS cells with potentiated Oct4
Abstract Leukemia inhibitory factor (LIF) is widely used to establish and maintain naïve pluripotent stem cells, including mouse embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Although the combination of chemical inhibitors...
2015 / Hiroyuki Hirai, Meri Firpo, Nobuaki Kikyo -
Detection of internally infested popcorn using electrically conductive roller mills
Abstract To detect popcorn kernels infested by the internal feeding stored-product insect pest Sitophilus zeamais, maize weevil, a laboratory roller mill was modified so that the electrical conductivity of the grain is measured while the kernels are ...
2016 / D. Brabec, F. Dowell, J. Campbell, M. West -
Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production2013 / Julio E. Molineros, Amit K. Maiti, Celi Sun, Loren L. Looger, Shizhong Han, et al.
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Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses
Summary Expansion and acquisition of Th1 cell effector function requires metabolic reprogramming; however, the signals instructing these adaptations remain poorly defined. Here we found that in activated human T cells, autocrine stimulation of the...
2015 / Martin Kolev, Sarah Dimeloe, Gaelle Le Friec, Alexander Navarini, Giuseppina Arbore, et al. -
Cell shape dynamics during the staphylococcal cell cycle2015 / João M. Monteiro, Pedro B. Fernandes, Filipa Vaz, Ana R. Pereira, Andreia C. Tavares, et al.
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The capture proteasome assay (CAPA) to evaluate subtype-specific proteasome inhibitors
Abstract We recently developed a new assay to measure proteasome activity in vitro (CAPA for capture proteasome assay) [1], based on proteasome capture on an antibody-coated plate. When used with lysates originating from cells expressing either...
2015 / Nathalie Vigneron, Joanna Abi Habib, Benoît J. Van den Eynde -
Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs
Summary The malaria parasite Plasmodium falciparum replicates within erythrocytes, producing progeny merozoites that are released from infected cells via a poorly understood process called egress. The most abundant merozoite surface protein, MSP1,...
2015 / Sujaan Das, Nadine Hertrich, Abigail J. Perrin, Chrislaine Withers-Martinez, Christine R. Collins, et al. -
Hopx distinguishes hippocampal from lateral ventricle neural stem cells
Abstract In the adult dentate gyrus (DG) and in the proliferative zone lining the lateral ventricle (LV-PZ), radial glia-like (RGL) cells are neural stem cells (NSCs) that generate granule neurons. A number of molecular markers including glial...
2015 / Deqiang Li, Norifumi Takeda, Rajan Jain, Lauren J. Manderfield, Feiyan Liu, et al. -
The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease
Abstract Parkinson's disease (PD), caused by selective loss of dopaminergic (DA) neurons in the substantia nigra, is the most common movement disorder with no cure or effective treatment. Exposure to the mitochondrial complex I inhibitor rotenone...
2014 / Ran-Der Hwang, Lyle Wiemerslage, Christopher J. LaBreck, Munzareen Khan, Kavitha Kannan, et al. -
uPAR-controlled oncolytic adenoviruses eliminate cancer stem cells in human pancreatic tumors
Abstract Pancreatic tumors contain cancer stem cells highly resistant to chemotherapy. The identification of therapies that can eliminate this population of cells might provide with more effective treatments. In the current work we evaluated the...
2013 / Luciano Sobrevals, Ana Mato-Berciano, Nerea Urtasun, Adela Mazo, Cristina Fillat -
Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis
Abstract It is well established that ionizing radiation induces chromosomal damage, both following direct radiation exposure and via non-targeted (bystander) effects, activating DNA damage repair pathways, of which the proteins are closely linked to ...
2014 / Grace Shim, Michelle Ricoul, William M. Hempel, Edouard I. Azzam, Laure Sabatier -
Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury2015 / Weiwei Lin, Na Yuan, Zhen Wang, Yan Cao, Yixuan Fang, et al.
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High fat diet-induced modifications in membrane lipid and mitochondrial-membrane protein signatures precede the development of hepatic insulin resistance in mice
Abstract Objective Excess lipid intake has been implicated in the pathophysiology of hepatosteatosis and hepatic insulin resistance. Lipids constitute approximately 50% of the cell membrane mass, define membrane properties, and...
2014 / M. Kahle, A. Schäfer, A. Seelig, J. Schultheiß, M. Wu, et al. -
Testing the genetic predictions of a biogeographical model in a dominant endemic Eastern Pacific coral ( Porites panamensis ) using a genetic seascape approach2013 / Nancy C. Saavedra-Sotelo, Luis E. Calderon-Aguilera, Héctor Reyes-Bonilla, David A. Paz-García, Ramón A. López-Pérez, et al.
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Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal
Summary Oncogenic transcription factors such as RUNX1/ETO, which is generated by the chromosomal translocation t(8;21), subvert normal blood cell development by impairing differentiation and driving malignant self-renewal. Here, we use digital...
2014 / Anetta Ptasinska, Salam A. Assi, Natalia Martinez-Soria, Maria Rosaria Imperato, Jason Piper, et al. -
Development and Validation of a Mass Spectrometry–Based Assay for the Molecular Diagnosis of Mucin-1 Kidney Disease
Mucin-1 kidney disease, previously described as medullary cystic kidney disease type 1 (MCKD1, OMIM 174000), is an autosomal dominant tubulointerstitial kidney disease recently shown to be caused by a single-base insertion within the variable number tandem repeat...
2016 / Brendan Blumenstiel, Matthew DeFelice, Ozge Birsoy, Anthony J. Bleyer, Stanislav Kmoch, et al. -
Effects of ambient noise on detectability and localization of avian songs and tones by observers in grasslands2015 / Nicola Koper, Lionel Leston, Tyne M. Baker, Claire Curry, Patricia Rosa
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oxBS-450K: A method for analysing hydroxymethylation using 450K BeadChips
Abstract DNA methylation analysis has become an integral part of biomedical research. For high-throughput applications such as epigenome-wide association studies, the Infinium HumanMethylation450 (450K) BeadChip is currently the platform of choice....
2014 / Sabrina K. Stewart, Tiffany J. Morris, Paul Guilhamon, Harry Bulstrode, Martin Bachman, et al.