Biological sciences topic list of research papers
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The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis2008 / M. J. Bull, A. S. Williams, Z. Mecklenburgh, C. J. Calder, J. P. Twohig, et al.
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Nested theta to gamma oscillations and precise spatiotemporal firing during memory retrieval in a simulated attractor network
Abstract Nested oscillations, where the phase of the underlying slow rhythm modulates the power of faster oscillations, have recently attracted considerable research attention as the increased phase-coupling of cross-frequency oscillations has been...
2013 / Pawel Andrzej Herman, Mikael Lundqvist, Anders Lansner -
An extensive analysis of disease-gene associations using network integration and fast kernel-based gene prioritization methods
Abstract Objective In the context of “network medicine”, gene prioritization methods represent one of the main tools to discover candidate disease genes by exploiting the large amount of data covering different types of functional...
2014 / Giorgio Valentini, Alberto Paccanaro, Horacio Caniza, Alfonso E. Romero, Matteo Re -
Thoracic-to-hip circumference ratio as a novel marker of type 2 diabetes, independent of body mass index and waist-to-hip ratio, in Korean adults
Abstract Aims We compared upper trunk anthropometric indices with overall and central obesity indicators to predict the presence of type 2 diabetes in middle-aged and elderly Korean individuals. ...
2014 / Duong Duc Pham, BonCho Ku, Chol Shin, Nam H. Cho, Seongwon Cha, et al. -
AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and dose dependent reduction of tyrosine kinase activity in acute myeloid leukemia
Abstract AKN-028 is a novel tyrosine kinase inhibitor with preclinical activity in acute myeloid leukemia (AML), presently undergoing investigation in a phase I/II study. It is a potent inhibitor of the FMS-like kinase 3 (FLT3) but shows in vitro...
2013 / Anna Eriksson, Antonia Kalushkova, Malin Jarvius, Riet Hilhorst, Linda Rickardson, et al. -
Tuberculosis vaccine research in China2012 / Douglas B Lowrie
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Two organic mercury compounds tested for mutagenicity in mammalian cells by use of the cell line V 79-42009 / GEIRID FISKESJÖ
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Establishment of bone marrow and hematopoietic niches in vivo by reversion of chondrocyte differentiation of human bone marrow stromal cells
Abstract Human bone marrow stromal cells (BMSCs, also known as bone marrow-derived “mesenchymal stem cells”) can establish the hematopoietic microenvironment within heterotopic ossicles generated by transplantation at non-skeletal sites. Here we...
2014 / Marta Serafini, Benedetto Sacchetti, Alice Pievani, Daniela Redaelli, Cristina Remoli, et al. -
G-Quadruplex (G4) Motifs in the Maize (Zea mays L.) Genome Are Enriched at Specific Locations in Thousands of Genes Coupled to Energy Status, Hypoxia, Low Sugar, and Nutrient Deprivation
Abstract The G-quadruplex (G4) elements comprise a class of nucleic acid structures formed by stacking of guanine base quartets in a quadruple helix. This G4 DNA can form within or across single-stranded DNA molecules and is mutually exclusive with...
2014 / Carson M. Andorf, Mykhailo Kopylov, Drena Dobbs, Karen E. Koch, M. Elizabeth Stroupe, et al. -
An Exploratory Analysis of Mitochondrial Haplotypes and Allogeneic Hematopoietic Cell Transplantation Outcomes
Abstract Certain mitochondrial haplotypes (mthaps) are associated with disease, possibly through differences in oxidative phosphorylation and/or immunosurveillance. We explored whether mthaps are associated with allogeneic hematopoietic cell...
2014 / Julie A. Ross, Jakub Tolar, Logan G. Spector, Todd DeFor, Troy C. Lund, et al. -
Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma2014 / Mariko Yoshimura, Jo Ishizawa, Vivian Ruvolo, Archana Dilip, Alfonso Quintás-Cardama, et al.
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Riluzole promotes motor and respiratory recovery associated with enhanced neuronal survival and function following high cervical spinal hemisection
Abstract Cervical spinal cord injury (SCI) can result in devastating functional deficits that involve the respiratory and hand function. The mammalian spinal cord has limited ability to regenerate and restore meaningful functional recovery following ...
2015 / K. Satkunendrarajah, F. Nassiri, S.K. Karadimas, A. Lip, G. Yao, et al. -
Emerging virus diseases: can we ever expect the unexpected?2012 / Colin R Howard, Nicola F Fletcher
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Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion
Summary Strategies for expanding hematopoietic stem cells (HSCs) include coculture with cells that recapitulate their natural microenvironment, such as bone marrow stromal stem/progenitor cells (BMSCs). Plastic-adherent BMSCs may be insufficient to...
2013 / Joan Isern, Beatriz Martín-Antonio, Roshanak Ghazanfari, Ana M. Martín, Juan A. López, et al. -
Severe disruption of the cytoskeleton and immunologically relevant surface molecules in a human macrophageal cell line in microgravity—Results of an in vitro experiment on board of the Shenzhou-8 space mission
Abstract During spaceflight the immune system is one of the most affected systems of the human body. During the SIMBOX (Science in Microgravity Box) mission on Shenzhou-8, we investigated microgravity-associated long-term alterations in macrophageal ...
2013 / Katrin Paulsen, Svantje Tauber, Nadine Goelz, Dana Michaela Simmet, Stephanie Engeli, et al. -
The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1
Abstract Disruption of the gene BSCL2 causes a severe, generalised lipodystrophy, demonstrating the critical role of its protein product, seipin, in human adipose tissue development. Seipin is essential for adipocyte differentiation, whilst the...
2012 / M.F. Michelle Sim, Rowena J. Dennis, Evelyne M. Aubry, Nardev Ramanathan, Hiroshi Sembongi, et al. -
Hemoglobin is present as a canonical α2β2 tetramer in dopaminergic neurons
Abstract Hemoglobin is the oxygen carrier in blood erythrocytes. Oxygen coordination is mediated by α2β2 tetrameric structure via binding of the ligand to the heme iron atom. This structure is essential for hemoglobin function in the blood. In the...
2013 / Roberta Russo, Silvia Zucchelli, Marta Codrich, Federica Marcuzzi, Cinzia Verde, et al. -
Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4
Abstract Mast cells (MCs) are found abundantly in the central nervous system and play a complex role in neuroinflammatory diseases such as multiple sclerosis and stroke. In the present study, we show that MC-deficient Kit ...
2013 / Sofie Nelissen, Tim Vangansewinkel, Nathalie Geurts, Lies Geboes, Evi Lemmens, et al. -
Targeting oxidized LDL improves insulin sensitivity and immune cell function in obese Rhesus macaques
Abstract Oxidation of LDL (oxLDL) is a crucial step in the development of cardiovascular disease. Treatment with antibodies directed against oxLDL can reduce atherosclerosis in rodent models through unknown mechanisms. We demonstrate that through a...
2013 / Shijie Li, Paul Kievit, Anna-Karin Robertson, Ganesh Kolumam, Xiumin Li, et al. -
SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation
Summary A key feature in Huntington disease (HD) is the accumulation of mutant Huntingtin (HTT) protein, which may be regulated by posttranslational modifications. Here, we define the primary sites of SUMO modification in the amino-terminal domain...
2013 / Jacqueline Gire O’Rourke, Jaclyn R. Gareau, Joseph Ochaba, Wan Song, Tamás Raskó, et al.