Biological sciences topic list of research papers
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The genetics of auricular development and malformation: New findings in model systems driving future directions for microtia research
Abstract Microtia is a term used to describe a wide array of phenotypic presentations of the outer ear. Although the majority of the cases are isolated in nature, much of our understanding of the causes of microtia has been driven by the...
2014 / Timothy C. Cox, Esra D. Camci, Siddharth Vora, Daniela V. Luquetti, Eric E. Turner -
Association of melanoma with intraepithelial neoplasia of the pancreas in three patients
Abstract Melanoma and pancreatic cancer are two low frequency types of cancer. In this study, three patients who developed both melanoma and intraepithelial neoplasia of the pancreas were tested for CDKN2A mutations and deletions, and investigated...
2014 / Felipe Fidalgo, Elimar Elias Gomes, Luciana Moredo Facure, Felipe Carneiro Da Silva, Dirce Maria Carraro, et al. -
Identification of candidate odorant degrading gene/enzyme systems in the antennal transcriptome of Drosophila melanogaster
Abstract The metabolism of volatile signal molecules by odorant degrading enzymes (ODEs) is crucial to the ongoing sensitivity and specificity of chemoreception in various insects, and a few specific esterases, cytochrome P450s, glutathione...
2014 / Faisal Younus, Thomas Chertemps, Stephen L. Pearce, Gunjan Pandey, Françoise Bozzolan, et al. -
Structure of fructose bisphosphate aldolase from Bartonella henselae bound to fructose 1,6-bisphosphate2011 / Anna Gardberg, Jan Abendroth, Janhavi Bhandari, Banumathi Sankaran, Bart Staker
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The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 Å resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator2009 / Constantina Bakolitsa, Alex Bateman, Kevin K. Jin, Daniel McMullan, S. Sri Krishna, et al.
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The potential impacts of migratory difficulty, including warmer waters and altered flow conditions, on the reproductive success of salmonid fishes
Abstract Climate change and urbanisation of watercourses affect water temperatures and current flow velocities in river systems on a global scale. This represents a particularly critical issue for migratory fish species with complex life histories...
2015 / Miriam Fenkes, Holly A. Shiels, John L. Fitzpatrick, Robert L. Nudds -
D2 dopamine receptor regulation of learning, sleep and plasticity
Abstract Dopamine and sleep have been independently linked with hippocampus-dependent learning. Since D2 dopaminergic transmission is required for the occurrence of rapid-eye-movement (REM) sleep, it is possible that dopamine affects learning by way ...
2015 / A.S.C. França, B. Lobão-Soares, L. Muratori, G. Nascimento, J. Winne, et al. -
Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A
Abstract Adipose triglyceride lipase (ATGL) is required for efficient mobilization of triglyceride (TG) stores in adipose tissue and non-adipose tissues. Therefore, ATGL strongly determines the availability of fatty acids for metabolic reactions....
2014 / Harald M. Nagy, Margret Paar, Christoph Heier, Tarek Moustafa, Peter Hofer, et al. -
Perlecan is required for FGF-2 signaling in the neural stem cell niche
Abstract In the adult subventricular zone (neurogenic niche), neural stem cells double-positive for two markers of subsets of neural stem cells in the adult central nervous system, glial fibrillary acidic protein and CD133, lie in proximity to...
2014 / Aurelien Kerever, Frederic Mercier, Risa Nonaka, Susana de Vega, Yuka Oda, et al. -
Intra-sexual competition alters the relationship between testosterone and ornament expression in a wild territorial bird
Abstract In a reliable signalling system, individual quality is expected to mediate the costs associated with ornamental displays, with relatively lower costs being paid by individuals of higher quality. These relative costs should depend not only...
2014 / J. Martínez-Padilla, L. Pérez-Rodríguez, F. Mougeot, S. Ludwig, S.M. Redpath -
Tc-cAPX, a cytosolic ascorbate peroxidase of Theobroma cacao L. engaged in the interaction with Moniliophthora perniciosa, the causing agent of witches' broom disease
Abstract The level of hydrogen peroxide (H2O2) in plants signalizes the induction of several genes, including that of ascorbate peroxidase (APX-EC 1.11.1.11). APX isoenzymes play a central role in the elimination of intracellular H2O2 and contribute ...
2013 / Luciana Rodrigues Camillo, Ciro Ribeiro Filadelfo, Paulo Sérgio Monzani, Ronan Xavier Corrêa, Karina Peres Gramacho, et al. -
Defensive responses of Brandt's voles (Lasiopodomys brandtii) to chronic predatory stress
Abstract Predator odors are non-intrusive natural stressors of high ethological relevance. The objective of this study was to investigate the processing of a chronic, life-threatening stimulus during repeated prolonged presentation to Brandt's...
2013 / Ibrahim M. Hegab, Guoshen Shang, Manhong Ye, Yajuan Jin, Aiqin Wang, et al. -
The accumulation of brain water-free sodium is associated with ischemic damage independent of the blood pressure in female rats
Abstract Estrogen deficiency worsens ischemic stroke outcomes. In ovariectomized (OVX+) rats fed a high-salt diet (HSD), an increase in the body Na+/water ratio, which characterizes water-free Na+ accumulation, was associated with detrimental...
2015 / Manabu Sumiyoshi, Keiko T. Kitazato, Kenji Yagi, Takeshi Miyamoto, Yoshitaka Kurashiki, et al. -
In vitro metabolism, disposition, preclinical pharmacokinetics and prediction of human pharmacokinetics of DNDI-VL-2098, a potential oral treatment for Visceral Leishmaniasis
Abstract The in vitro metabolism and in vivo pharmacokinetic (PK) properties of DNDI-VL-2098, a potential oral agent for Visceral Leishmaniasis (VL) were studied and used to predict its human pharmacokinetics. DNDI-VL-2098 showed a low solubility...
2014 / Rao Mukkavilli, Jakir Pinjari, Bhavesh Patel, Shankar Sengottuvelan, Subodh Mondal, et al. -
Modelling the vascular response to sympathetic postganglionic nerve activity
Abstract This paper explores the influence of burst properties of the sympathetic nervous system on arterial contractility. Specifically, a mathematical model is constructed of the pathway from action potential generation in a sympathetic...
2015 / Linford J.B. Briant, Julian F.R. Paton, Anthony E. Pickering, Alan R. Champneys -
Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions
Summary Hyporesponsiveness by phagocytes is a well-known phenomenon in sepsis that is frequently induced by low-dose endotoxin stimulation of Toll-like receptor 4 (TLR4) but can also be found under sterile inflammatory conditions. We now demonstrate ...
2014 / Judith Austermann, Judith Friesenhagen, Selina Kathleen Fassl, Theresa Ortkras, Johanna Burgmann, et al. -
Lipid Droplets: A New Player in Colorectal Cancer Stem Cells Unveiled by Spectroscopic Imaging2014 / Luca Tirinato, Carlo Liberale, Simone Di Franco, Patrizio Candeloro, Antonina Benfante, et al.
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Dendritic cells enhance the antigen sensitivity of T cells2012 / Natalio Garbi, Thomas Kreutzberg
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Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection
Abstract Keratinocytes constitute the majority of cells in the skin’s epidermis, the first line of defence against percutaneous pathogens. Schistosome larvae (cercariae) actively penetrate the epidermis to establish infection, however the response...
2015 / Claire D. Bourke, Catriona T. Prendergast, David E. Sanin, Tate E. Oulton, Rebecca J. Hall, et al. -
Risk factors of pandemic influenza A/H1N1 in a prospective household cohort in the general population: results from the CoPanFlu-France cohort2014 / Rosemary M. Delabre, Nathanael Lapidus, Nicolas Salez, Yohann Mansiaux, Xavier de Lamballerie, et al.