Biological sciences topic list of research papers
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The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: A novel possible model of OCD
Abstract Excessive checking is a common, debilitating symptom of obsessive-compulsive disorder (OCD). In an established rodent model of OCD checking behaviour, quinpirole (dopamine D2/3-receptor agonist) increased checking in open-field tests,...
2014 / Dawn M. Eagle, Cristie Noschang, Laure-Sophie Camilla d’Angelo, Christie A. Noble, Jacob O. Day, et al. -
In Vivo Clonal Analysis Reveals Lineage-Restricted Progenitor Characteristics in Mammalian Kidney Development, Maintenance, and Regeneration
Summary The mechanism and magnitude by which the mammalian kidney generates and maintains its proximal tubules, distal tubules, and collecting ducts remain controversial. Here, we use long-term in vivo genetic lineage tracing and clonal analysis of...
2014 / Yuval Rinkevich, Daniel T. Montoro, Humberto Contreras-Trujillo, Orit Harari-Steinberg, Aaron M. Newman, et al. -
Top-down characterization data on the speciation of the Candida albicans immunome in candidemia
Abstract The characterization of pathogen-specific antigenic proteins at the protein species level is crucial in the development and molecular optimization of novel immunodiagnostics, vaccines or immunotherapeutics for infectious diseases. The major ...
2015 / Aida Pitarch, César Nombela, Concha Gil -
Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast2014 / Elinor Sawyer, Rebecca Roylance, Christos Petridis, Mark N. Brook, Salpie Nowinski, et al.
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Drift fences in traps: theoretical evidence of effectiveness of the two most common arrays applied to terrestrial tetrapods
Abstract Biodiversity inventories are well acknowledged as key to conservation planning. One widely used method for sampling terrestrial fauna is traps with drift fences. Such drift fences, however, may be configured in several arrays, varying the...
2015 / Daniel Mincauscaste Mendes, Rafael de Freitas Leão, Luís Felipe Toledo -
LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia
Abstract Aims/Hypothesis Glucagon release from pancreatic alpha cells is required for normal glucose homoeostasis and is dysregulated in both Type 1 and Type 2 diabetes. The tumour suppressor LKB1 (STK11) and the downstream kinase...
2015 / Gao Sun, Gabriela da Silva Xavier, Tracy Gorman, Claire Priest, Antonia Solomou, et al. -
A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays
Abstract Cardiomyocytes from human stem cells have applications in regenerative medicine and can provide models for heart disease and toxicity screening. Soluble components of the culture system such as growth factors within serum and insoluble...
2015 / Asha K. Patel, Adam D. Celiz, Divya Rajamohan, Daniel G. Anderson, Robert Langer, et al. -
Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells
Summary Diabetic cardiomyopathy is a complication of type 2 diabetes, with known contributions of lifestyle and genetics. We develop environmentally and genetically driven in vitro models of the condition using...
2014 / Faye M. Drawnel, Stefano Boccardo, Michael Prummer, Frédéric Delobel, Alexandra Graff, et al. -
Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies2013 / Cristina Rodriguez-Fontenla, Manuel Calaza, Evangelos Evangelou, Ana M. Valdes, Nigel Arden, et al.
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The KnownLeaf literature curation system captures knowledge about Arabidopsis leaf growth and development and facilitates integrated data mining
Abstract The information that connects genotypes and phenotypes is essentially embedded in research articles written in natural language. To facilitate access to this knowledge, we constructed a framework for the curation of the scientific...
2015 / Dóra Szakonyi, Sofie Van Landeghem, Katja Baerenfaller, Lieven Baeyens, Jonas Blomme, et al. -
Human carboxylesterase 2: Studies on the role of glycosylation for enzymatic activity
Abstract Human carboxylesterase 2 (hCES2) is a glycoprotein involved in the metabolism of drugs and several environmental xenobiotics, whose crystallization has been proved to be a challenging task. This limitation could partly be due to...
2015 / Márcia Alves, Joana Lamego, Tiago Bandeiras, Rute Castro, Hélio Tomás, et al. -
The activity of the Synechocystis PCC6803 AbrB2 regulator of hydrogen production can be post-translationally controlled through glutathionylation
Abstract We show that the Synechocystis AbrB2 repressor of hydrogen production, down regulates the defence against oxidative stress. The single widely conserved cysteine of AbrB2 is also shown to play a crucial role in AbrB2 oligomerisation, and in...
2013 / Samer Sakr, Jeremy Dutheil, Panatda Saenkham, Hervé Bottin, Christophe Leplat, et al. -
A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes
Abstract We present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an approximate mathematical model, we employ...
2013 / Kieran Smallbone, Hanan L. Messiha, Kathleen M. Carroll, Catherine L. Winder, Naglis Malys, et al. -
Evidence of Inbreeding Depression on Human Height2012 / Ruth McQuillan, Niina Eklund, Nicola Pirastu, Maris Kuningas, Brian P. McEvoy, et al.
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Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms2011 / Guangju Zhai, Alexander Teumer, Lisette Stolk, John R. B. Perry, Liesbeth Vandenput, et al.
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Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes
Abstract Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and in APOEε4 carriers, decades before the onset of measureable cognitive deficits....
2014 / Shobana Sekar, Jacquelyn McDonald, Lori Cuyugan, Jessica Aldrich, Ahmet Kurdoglu, et al. -
Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury
Abstract We had previously shown that alcohol consumption can induce cellular isoaspartate protein damage via an impairment of the activity of protein isoaspartyl methyltransferase (PIMT), an enzyme that triggers repair of isoaspartate protein...
2015 / Wayne G. Carter, Vasanthy Vigneswara, Anna Newlaczyl, Declan Wayne, Bilal Ahmed, et al. -
The Pentameric Nucleoplasmin Fold Is Present in Drosophila FKBP39 and a Large Number of Chromatin-Related Proteins
Abstract Nucleoplasmin is a histone chaperone that consists of a pentameric N-terminal domain and an unstructured C-terminal tail. The pentameric core domain, a doughnut-like structure with a central pore, is only found in the nucleoplasmin family....
2015 / Christian Edlich-Muth, Jean-Baptiste Artero, Phil Callow, Marcin R. Przewloka, Aleksandra A. Watson, et al. -
Evaluation of limonoid production in suspension cell culture of Citrus sinensis2015 / Elisângela Fumagali Gerolino, Talita Perez Cantuaria Chierrito, Arquimedes Santana Filho, Eliezer Rodrigues Souto, Regina Aparecida Correia Gonçalves, et al.
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In vitro and in vivo antifungal activity, liver profile test, and mutagenic activity of five plants used in traditional Mexican medicine2015 / Jorge Cornejo-Garrido, Martha Salinas-Sandoval, Arely Díaz-López, Patricia Jácquez-Ríos, Myriam Arriaga-Alba, et al.