Biological sciences topic list of research papers
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Lysine acetylation of major Chlamydia trachomatis antigens
Abstract Chlamydia trachomatis (Ct) is a human pathogen causing trachoma and infertility. We investigated acetylation at lysine residues of chlamydial antigenic proteins: major outer membrane protein (MOMP), 60kDa chaperonin...
2016 / Jelena Mihailovic, Aleksandra Inic-Kanada, Katarina Smiljanic, Elisabeth Stein, Talin Barisani-Asenbauer, et al. -
Characterization of plants expressing the human β1,4-galactosyltrasferase gene
Abstract Modification of the plant N-glycosylation pathway towards human type structures is an important strategy to implement plants as expression systems for therapeutic proteins. Nevertheless, relatively little is known about the overall impact...
2015 / Jeannine Schneider, Alexandra Castilho, Martin Pabst, Friedrich Altmann, Clemens Gruber, et al. -
Comparative genomics of Bacillus anthracis from the wool industry highlights polymorphisms of lineage A.Br.Vollum
Abstract Background With the advent of affordable next-generation sequencing (NGS) technologies, major progress has been made in the understanding of the population structure and evolution of the B. anthracis species. Here we...
2016 / Sylviane Derzelle, Lisandra Aguilar-Bultet, Joachim Frey -
Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin
Abstract The hormone ghrelin stimulates eating and helps maintain blood glucose upon caloric restriction. While previous studies have demonstrated that hypothalamic arcuate AgRP neurons are targets of ghrelin, the overall relevance of ghrelin...
2013 / Qian Wang, Chen Liu, Aki Uchida, Jen-Chieh Chuang, Angela Walker, et al. -
Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index2014 / Clive J. Hoggart, Giulia Venturini, Massimo Mangino, Felicia Gomez, Giulia Ascari, et al.
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ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma2014 / Monisha E. Nongpiur, Chiea Chuen Khor, Hongyan Jia, Belinda K. Cornes, Li-Jia Chen, et al.
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Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome
Summary Excess iron induces tissue damage and is implicated in age-related macular degeneration (AMD). Iron toxicity is widely attributed to hydroxyl radical formation through Fenton’s reaction. We report that excess iron, but not other Fenton...
2015 / Bradley D. Gelfand, Charles B. Wright, Younghee Kim, Tetsuhiro Yasuma, Reo Yasuma, et al. -
The First Myriapod Genome Sequence Reveals Conservative Arthropod Gene Content and Genome Organisation in the Centipede Strigamia maritima2014 / Ariel D. Chipman, David E. K. Ferrier, Carlo Brena, Jiaxin Qu, Daniel S. T. Hughes, et al.
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An aquaporin protein is associated with drought stress tolerance
Abstract Water channel proteins known as aquaporins (AQPs) regulate the movement of water and other small molecules across plant vacuolar and plasma membranes; they are associated with plant tolerance of biotic and abiotic stresses. In this study, a ...
2015 / Jun Li, Liping Ban, Hongyu Wen, Zan Wang, Nikolay Dzyubenko, et al. -
Therapeutic targeting of replicative immortality
Abstract One of the hallmarks of malignant cell populations is the ability to undergo continuous proliferation. This property allows clonal lineages to acquire sequential aberrations that can fuel increasingly autonomous growth, invasiveness, and...
2015 / Paul Yaswen, Karen L. MacKenzie, W. Nicol Keith, Patricia Hentosh, Francis Rodier, et al. -
Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains
Summary Therapeutics that target ERBB2, such as lapatinib, often provide initial clinical benefit, but resistance frequently develops. Adaptive responses leading to lapatinib resistance involve reprogramming of the kinome through reactivation of...
2015 / Timothy J. Stuhlmiller, Samantha M. Miller, Jon S. Zawistowski, Kazuhiro Nakamura, Adriana S. Beltran, et al. -
Are all species necessary to reveal ecologically important patterns?2014 / Edwin Pos, Juan Ernesto Guevara Andino, Daniel Sabatier, Jean-François Molino, Nigel Pitman, et al.
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Systematic evaluation of non-animal test methods for skin sensitisation safety assessment
Abstract The need for non-animal data to assess skin sensitisation properties of substances, especially cosmetics ingredients, has spawned the development of many in vitro methods. As it is widely believed that no single method can provide a...
2014 / Kerstin Reisinger, Sebastian Hoffmann, Nathalie Alépée, Takao Ashikaga, Joao Barroso, et al. -
Essential versus accessory aspects of cell death: recommendations of the NCCD 20152014 / L Galluzzi, J M Bravo-San Pedro, I Vitale, S A Aaronson, J M Abrams, et al.
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Isolation and Biochemical Characterization of a New Thrombin-Like Serine Protease from Bothrops pirajai Snake Venom2014 / Kayena D. Zaqueo, Anderson M. Kayano, Rodrigo Simões-Silva, Leandro S. Moreira-Dill, Carla F. C. Fernandes, et al.
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Characterization of QTL for unique agronomic traits of new-plant-type rice varieties using introgression lines of IR64
Abstract To enhance the yield potential of an elite indica rice cultivar, an introgression (BC3-derived) line of IR64, YTH288, was developed using a new-plant-type cultivar, IR66215-44-2-3, as a donor parent. YTH288 has agronomically valuable...
2015 / Analiza G. Tagle, Daisuke Fujita, Leodegario A. Ebron, Mary Jeanie Telebanco-Yanoria, Kazuhiro Sasaki, et al. -
Data for comparative proteomics of ovaries from five non-model, crustacean amphipods
Abstract Ovaries were taken from five sexually mature amphipods: Gammarus fossarum, Gammarus pulex, Gammarus roeseli, Hyallela azteca and Parhyale hawaiensis. The soluble proteome extracted from individual pair of ovaries from five biological...
2015 / Judith Trapp, Christine Almunia, Jean-Charles Gaillard, Olivier Pible, Arnaud Chaumot, et al. -
In vitro anti-Leishmania infantum activity of essential oil from Piper angustifolium2015 / Lauriane S.S. Bosquiroli, Daniel P. Demarque, Yasmin S. Rizk, Marillin C. Cunha, Maria Carolina S. Marques, et al.
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The World Saffron and Crocus collection: strategies for establishment, management, characterisation and utilisation2010 / José-Antonio Fernández, Omar Santana, José-Luis Guardiola, Rosa-Victoria Molina, Pat Heslop-Harrison, et al.
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Sequestration of DROSHA and DGCR8 by Expanded CGG RNA Repeats Alters MicroRNA Processing in Fragile X-Associated Tremor/Ataxia Syndrome
Summary Fragile X-associated tremor/ataxia syndrome (FXTAS) is an inherited neurodegenerative disorder caused by the expansion of 55–200 CGG repeats in the 5′ UTR of FMR1. These expanded CGG repeats are transcribed and accumulate in nuclear RNA...
2013 / Chantal Sellier, Fernande Freyermuth, Ricardos Tabet, Tuan Tran, Fang He, et al.