Biological sciences topic list of research papers
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Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties
Abstract Extracellular vesicles (EVs) are natural nanoparticles that mediate intercellular transfer of RNA and proteins and are of great medical interest; serving as novel biomarkers and potential therapeutic agents. However, there is little...
2015 / Joel Z. Nordin, Yi Lee, Pieter Vader, Imre Mäger, Henrik J. Johansson, et al. -
Biological Robustness: Paradigms, Mechanisms, and Systems Principles2012 / James Michael Whitacre
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Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants2013 / J. Romanos, A. Rosen, V. Kumar, G. Trynka, L. Franke, et al.
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Structures of a putative ζ-class glutathione S -transferase from the pathogenic fungus Coccidioides immitis2011 / Thomas E. Edwards, Cassie M. Bryan, David J. Leibly, Shellie H. Dieterich, Jan Abendroth, et al.
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Structure of the γ- D -glutamyl- L -diamino acid endopeptidase YkfC from Bacillus cereus in complex with L -Ala-γ- D -Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases2010 / Qingping Xu, Polat Abdubek, Tamara Astakhova, Herbert L. Axelrod, Constantina Bakolitsa, et al.
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Exonuclease 1 is essential for maintaining genomic stability and the proliferative capacity of neural but not hematopoietic stem cells
Abstract Exonuclease 1 (Exo1) has been implicated in the regulation of DNA damage responses in stem cells with dysfunctional telomeres. However, it is unclear whether Exo1-mediated DNA maintenance pathways play a role in the maintenance of genomic...
2013 / Junling Zhang, Runan Yang, Daohong Zhou, Karl Lenhard Rudolph, Aimin Meng, et al. -
Creating stable stem regions for loop elongation in Fcabs — Insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations
Abstract Fcabs (Fc antigen binding) are crystallizable fragments of IgG where the C-terminal structural loops of the CH3 domain are engineered for antigen binding. For the design of libraries it is beneficial to know positions that will permit loop...
2014 / Christoph Hasenhindl, Balder Lai, Javier Delgado, Michael W. Traxlmayr, Gerhard Stadlmayr, et al. -
Does covering of farm-associated Culicoides larval habitat reduce adult populations in the United Kingdom?
Abstract Culicoides biting midges (Diptera: Ceratopogonidae) are the biological vectors of a range of internationally important arboviruses of livestock, including bluetongue virus (BTV) and the recently emerging Schmallenberg...
2013 / L.E. Harrup, S. Gubbins, J. Barber, E. Denison, P.S. Mellor, et al. -
Decorin differentially modulates the activity of insulin receptor isoform A ligands
Abstract The proteoglycan decorin, a key component of the tumor stroma, regulates the action of several tyrosine-kinase receptors, including the EGFR, Met and the IGF-IR. Notably, the action of decorin in regulating the IGF-I system differs between...
2014 / Alaide Morcavallo, Simone Buraschi, Shi-Qiong Xu, Antonino Belfiore, Liliana Schaefer, et al. -
The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease
Abstract β-Amyloid (Aβ)-induced toxicity and oxidative stress have been postulated to play critical roles in the pathogenic mechanism of Alzheimer disease (AD). We investigated the in vivo ability of a mitochondria-targeted antioxidant, MitoQ, to...
2014 / Li Fang Ng, Jan Gruber, Irwin K. Cheah, Chong Kit Goo, Wei Fun Cheong, et al. -
Stereochemical conversion of C3-vinyl group to 1-hydroxyethyl group in bacteriochlorophyll c by the hydratases BchF and BchV: adaptation of green sulfur bacteria to limited-light environments2015 / Jiro Harada, Misato Teramura, Tadashi Mizoguchi, Yusuke Tsukatani, Ken Yamamoto, et al.
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The chromosome 9 ALS and FTD locus is probably derived from a single founder
Abstract We and others have recently reported an association between amyotrophic lateral sclerosis (ALS) and single nucleotide polymorphisms on chromosome 9p21 in several populations. Here we show that the associated haplotype is the same in all...
2011 / Kin Mok, Bryan J. Traynor, Jennifer Schymick, Pentti J. Tienari, Hannu Laaksovirta, et al. -
Effects of male targeted harvest regime on sexual segregation in mountain lion
Abstract Male targeted harvest regimes of carnivores are now widely accepted to result in increased sexually selected infanticide (SSI). Male targeted harvest regimes of males should therefore result in increased sexually segregated habitat use in...
2015 / Jon R. Keehner, Robert B. Wielgus, Benjamin T. Maletzke, Mark E. Swanson -
Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders
Summary As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and...
2015 / Kristen J. Brennand, M. Carol Marchetto, Nissim Benvenisty, Oliver Brüstle, Allison Ebert, et al. -
The genome of Tetranychus urticae reveals herbivorous pest adaptations2011 / Miodrag Grbić, Thomas Van Leeuwen, Richard M. Clark, Stephane Rombauts, Pierre Rouzé, et al.
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Arabidopsis CULLIN3 Genes Regulate Primary Root Growth and Patterning by Ethylene-Dependent and -Independent Mechanisms2009 / Alexis Thomann, Esther Lechner, Maureen Hansen, Eva Dumbliauskas, Yves Parmentier, et al.
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Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex
Abstract The species of the Leishmania donovani species complex cause visceral leishmaniasis, a debilitating infectious disease transmitted by sandflies. Understanding molecular changes associated with population structure in these parasites can...
2011 / Tim Downing, Olivia Stark, Manu Vanaerschot, Hideo Imamura, Mandy Sanders, et al. -
Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations2009 / Andrew A. Hicks, Peter P. Pramstaller, Åsa Johansson, Veronique Vitart, Igor Rudan, et al.
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The Functional Significance of Synaptotagmin Diversity in Neuroendocrine Secretion2013 / Paanteha K. Moghadam, Meyer B. Jackson
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Variation in the number of nucleoli and incomplete homogenization of 18S ribosomal DNA sequences in leaf cells of the cultivated Oriental ginseng (Panax ginseng Meyer)
Abstract Background Wild ginseng, Panax ginseng Meyer, is an endangered species of medicinal plants. In the present study, we analyzed variations within the ribosomal DNA (rDNA) cluster to gain insight into the genetic diversity of ...
2015 / Galina N. Chelomina, Konstantin V. Rozhkovan, Anastasia N. Voronova, Olga L. Burundukova, Tamara I. Muzarok, et al.