Biological sciences topic list of research papers
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High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites
Abstract The human genome encodes a gene for an enzymatically active chitinase (CHIT1) located in a single copy on Chromosome 1, which is highly expressed by activated macrophages and in other cells of the innate immune response. Several...
2014 / N. Manno, S. Sherratt, F. Boaretto, F. Mejìa Coico, C. Espinoza Camus, et al. -
l-Dopa induced dyskinesias in Parkinsonian mice: Disease severity or l-Dopa history
Abstract In Parkinson’s disease, the efficacy of l-Dopa treatment changes over time, as dyskinesias emerge with previously beneficial doses. Using MitoPark mice, that models mitochondrial failure in dopamine (DA) neurons and mimics the progressive...
2015 / Lufei Shan, Oscar Diaz, Yajun Zhang, Bruce Ladenheim, Jean-Lud Cadet, et al. -
Adipose tissue immunity and cancer2013 / Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, Gema Frühbeck
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Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke
Abstract Neurologic conditions including stroke, Alzheimer disease, Parkinson disease, and Huntington disease are leading causes of death and long-term disability in the United States, and efforts to develop novel therapeutics for these conditions...
2013 / Rachel E. Speer, Saravanan S. Karuppagounder, Manuela Basso, Sama F. Sleiman, Amit Kumar, et al. -
Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors
Summary Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in the SWI/SNF subunit SMARCB1. Here,...
2016 / Jocelyn P. Wong, Jason R. Todd, Martina A. Finetti, Frank McCarthy, Malgorzata Broncel, et al. -
Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis
Abstract Objective Disruption of the genes encoding either seipin or 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) causes severe congenital generalized lipodystrophy (CGL) in humans. However, the function of seipin in...
2015 / Md. Mesbah Uddin Talukder, M.F. Michelle Sim, Stephen O'Rahilly, J. Michael Edwardson, Justin J. Rochford -
NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling
Abstract The activity of the Wnt pathway undergoes complex regulation to ensure proper functioning of this principal signaling mechanism during development of adult tissues. The regulation may occur at several levels and includes both positive and...
2014 / Jitka Stancikova, Michaela Krausova, Michal Kolar, Bohumil Fafilek, Jiri Svec, et al. -
Phages Affect Gene Expression and Fitness in E. coli2005 /
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Metagenetic analysis of patterns of distribution and diversity of marine meiobenthic eukaryotes2014 / Vera G. Fonseca, Gary R. Carvalho, Ben Nichols, Christopher Quince, Harriet F. Johnson, et al.
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Exp2 polymorphisms associated with variation for fiber quality properties in cotton (Gossypium spp.)
Abstract Plant expansins are a group of extracellular proteins thought to affect the quality of cotton fibers. Previous expression profile analysis revealed that six Expansin A genes are present in cotton, of which two (GhExp1 and GhExp2) produce...
2014 / Daohua He, Zhongping Lei, Hongyi Xing, Baoshan Tang, Junxing Zhao, et al. -
MCLIP, an effective method to detect interactions of transmembrane proteins of the nuclear envelope in live cells
Abstract Investigating interactions of proteins in the nuclear envelope (NE) using co-immunoprecipitation (Co-IP) has previously been difficult or even impossible due to their inherent resistance to extraction. We have developed a novel method,...
2014 / Mohammed Hakim Jafferali, Balaje Vijayaraghavan, Ricardo A. Figueroa, Ellinor Crafoord, Santhosh Gudise, et al. -
High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury
Abstract After traumatic spinal cord injury, functional deficits increase as axons die back from the center of the lesion and the glial scar forms. Axonal dieback occurs in two phases: an initial axon intrinsic stage that occurs over the first...
2014 / Teresa A. Evans, Deborah S. Barkauskas, Jay T. Myers, Elisabeth G. Hare, Jing Qiang You, et al. -
Giant cell formation: the way to cell death or cell survival?2011 / Rostyslav Horbay, Rostyslav Stoika
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Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis2013 / Jacob B. Spangler, Frank Alex Feltus
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Safety and immunogenicity of an adjuvanted protein therapeutic HIV-1 vaccine in subjects with HIV-1 infection: A randomised placebo-controlled study
Abstract The human immunodeficiency virus type-1 (HIV-1) vaccine candidate F4/AS01 has previously been shown to induce potent and persistent polyfunctional CD4+ T-cell responses in HIV-1-seronegative volunteers. This placebo-controlled study...
2013 / Thomas Harrer, Andreas Plettenberg, Keikawus Arastéh, Jan Van Lunzen, Gerd Fätkenheuer, et al. -
Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse
Abstract Parkinson's disease (PD) is a neurodegenerative disorder classically characterized by the death of dopamine (DA) neurons in the substantia nigra pars compacta and by intracellular Lewy bodies composed largely of α-synuclein. Approximately...
2013 / Tonya N. Taylor, Dawid Potgieter, Sabina Anwar, Steven L. Senior, Stephanie Janezic, et al. -
In situ observations of a doliolid bloom in a warm water filament using a video plankton recorder: Bloom development, fate, and effect on biogeochemical cycles and planktonic food webs2015 / Kazutaka Takahashi, Tadafumi Ichikawa, Chika Fukugama, Misaki Yamane, Shigeho Kakehi, et al.
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Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging2013 / Erik B. van den Akker, Willemijn M. Passtoors, Rick Jansen, Erik W. van Zwet, Jelle J. Goeman, et al.
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Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease
Summary We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC family amplifications and P53 pathway defects commonly emerged at relapse, and all patients ...
2014 / Rebecca M. Hill, Sanne Kuijper, Janet C. Lindsey, Kevin Petrie, Ed C. Schwalbe, et al. -
Endometriosis, a disease of the macrophage2013 / Annalisa Capobianco