Chemical sciences topic list of research papers
-
The membrane complexome of a new Pseudomonas strain during growth on lysogeny broth medium and medium containing glucose or phenol
Abstract In this study, we have performed a systematic analysis of Pseudomonas sp. strain phDV1 membrane protein complexes by growing the strain in lysogeny broth medium, and medium containing glucose or phenol as sole carbon sources. In order to...
2014 / Antigoni Nikolaki, Anastasia Papadioti, Katerina Arvaniti, Eleni Kassotaki, Julian D. Langer, et al. -
An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants
Abstract An azide-functionalised analogue of the oxazolidinone antibiotic linezolid was synthesised and shown to retain antimicrobial activity. Using facile ‘click’ chemistry, this versatile intermediate can be further functionalised to explore...
2014 / Wanida Phetsang, Mark A.T. Blaskovich, Mark S. Butler, Johnny X. Huang, Johannes Zuegg, et al. -
Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin2012 / Uwe Mueller, Nora Darowski, Martin R. Fuchs, Ronald Förster, Michael Hellmig, et al.
-
Arenedisulfonate-4d–4f 3D heterometallic coordination polymers constructed from 2,7-naphthalenedisulfonate and isonicotinic acid: Structure, luminescence, and magnetic properties
Abstract The first example of 3D heterometallic 4d–4f 2,7-naphthanlenedisulfonate compounds [LnAg2(2,7-NDS)(IN)3] (Ln=Sm (1), Eu (2), Gd (3), Tb (4), Dy(5); 2,7-NDS=2,7-naphthanlenedisulfonate; IN=isonicotinic acid) has been synthesized via...
2013 / Wei-Ping Xie, Ning Wang, Yi Long, Xing-Rui Ran, Jin-Ying Gao, et al. -
N , N -Diethylanilinium 5-(2,4-dinitrophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-olate2012 / Doraisamyraja Kalaivani, Govindan Mangaiyarkarasi
-
Polyphenolic C-glucosidic ellagitannins present in oak-aged wine inhibit HIV-1 nucleocapsid protein
Abstract HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone implicated in several steps of the virus replication cycle and an attractive new target for drug development. In reverse transcription, NC destabilizes nucleic acid secondary...
2015 / Alice Sosic, Marta Cappellini, Laura Sinigaglia, Rémi Jacquet, Denis Deffieux, et al. -
( E )-2-(1,3-Diphenylallylidene)malononitrile2009 / Tai-Ran Kang, Lian-Mei Chen
-
Possibilities and limitations of current technologies for quantification of biological extracellular vesicles and synthetic mimics
Abstract Nano-sized extracelullar vesicles (EVs) released by various cell types play important roles in a plethora of (patho)physiological processes and are increasingly recognized as biomarkers for disease. In addition, engineered EV and...
2014 / Sybren L.N. Maas, Jeroen de Vrij, Els J. van der Vlist, Biaina Geragousian, Louis van Bloois, et al. -
Simultaneous determination of nineteen major components in Qi She Pill by ultra-high-performance liquid chromatography–tandem mass spectrometry
Abstract Qi She Pill (QSP) is a traditional Chinese medicine (TCM) prescription that has been used in treating cervical spondylosis radiculopathy for many years. In this study, a simple and sensitive method using ultra-high-performance liquid...
2014 / Zhongliang Zhang, Qiang Li, Qiufen Li, Simiao Du, Yongquan Zhou, et al. -
Membrane protein synthesis in cell-free systems: From bio-mimetic systems to bio-membranes
Abstract When taking up the gauntlet of studying membrane protein functionality, scientists are provided with a plethora of advantages, which can be exploited for the synthesis of these difficult-to-express proteins by utilizing cell-free protein...
2014 / Rita Sachse, Srujan K. Dondapati, Susanne F. Fenz, Thomas Schmidt, Stefan Kubick -
Pharmacokinetics, biodistribution and metabolism of squalenoyl adenosine nanoparticles in mice using dual radio-labeling and radio-HPLC analysis
Abstract Adenosine is a pleiotropic endogenous nucleoside with potential neuroprotective pharmacological activity. However, clinical use of adenosine is hampered by its extremely fast metabolization. To overcome this limitation, we recently...
2015 / Alice Gaudin, Sinda Lepetre-Mouelhi, Julie Mougin, Martine Parrod, Grégory Pieters, et al. -
Bioactivity in silica/poly(γ-glutamic acid) sol–gel hybrids through calcium chelation
Abstract Bioactive glasses and inorganic/organic hybrids have great potential as biomedical implant materials. Sol–gel hybrids with interpenetrating networks of silica and biodegradable polymers can combine the bioactive properties of a glass with...
2013 / Esther M. Valliant, Frederik Romer, Daming Wang, David S. McPhail, Mark E. Smith, et al. -
Data for a comprehensive map and functional annotation of the human cerebrospinal fluid proteome
Abstract Knowledge about the normal human cerebrospinal fluid (CSF) proteome serves as a baseline reference for CSF biomarker discovery and provides insight into CSF physiology. In this study, high-pH reverse-phase liquid chromatography (hp-RPLC)...
2015 / Yang Zhang, Zhengguang Guo, Lili Zou, Yehong Yang, Liwei Zhang, et al. -
Two decades of chemical imaging of solutes in sediments and soils – a review
Abstract The increasing appreciation of the small-scale (sub-mm) heterogeneity of biogeochemical processes in sediments, wetlands and soils has led to the development of several methods for high-resolution two-dimensional imaging of solute...
2015 / Jakob Santner, Morten Larsen, Andreas Kreuzeder, Ronnie N. Glud -
HPLC-MS/MS method validation for the detection of carbadox and olaquindox in poultry and swine feedingstuffs
Abstract Carbadox (CBX) and olaquindox (OLA) were used in poultry and swine feed for growth promotion, to improve feed efficiency and increase the rate of weight gain. However, the use of these agents in feedingstuffs was prohibited because of...
2015 / Wagner Lutero Souza Dibai, Juarez Fabiano de Alkimin Filho, Fabiano Aurélio da Silva Oliveira, Débora Cristina Sampaio de Assis, Leonardo José Camargos Lara, et al. -
Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins
Abstract In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1–9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical evaluation of ADME ...
2013 / Maria João Matos, Fernanda Pérez-Cruz, Saleta Vazquez-Rodriguez, Eugenio Uriarte, Lourdes Santana, et al. -
Superhydrophobic polymeric coatings produced by rapid expansion of supercritical solutions combined with electrostatic deposition (RESS-ED)
Abstract In this paper we present a method to produce superhydrophobic polymeric coatings by combining the rapid expansion of supercritical solutions (RESS) with electrostatic deposition (ED). A copolymer, poly(vinyl acetate)–poly(vinyl pivalate)...
2014 / Louise Ovaskainen, Samuel Chigome, Natasha A. Birkin, Steven M. Howdle, Nelson Torto, et al. -
A real-time in vitro assay as a potential predictor of in vivo tumor imaging properties
Abstract Introduction Selective tumor targeting strategies based on cell surface molecules enable new personalized diagnosis and treatments, potentially lowering adverse effects and increasing efficacy. Radio-immunotargeting...
2015 / Diana Spiegelberg, Jonas Stenberg, Anna-Karin Haylock, Marika Nestor -
Chemical databases: curation or integration by user-defined equivalence?
There is a wealth of valuable chemical information in publicly available databases for use by scientists undertaking drug discovery. However finite curation resource, limitations of chemical structure software and differences in individual database applications...
2015 / Anne Hersey, Jon Chambers, Louisa Bellis, A. Patrícia Bento, Anna Gaulton, et al. -
Biobutanol production by Clostridium acetobutylicum using xylose recovered from birch Kraft black liquor
Abstract Acetone–butanol–ethanol (ABE) fermentation was studied using acid-hydrolyzed xylan recovered from hardwood Kraft black liquor by CO2 acidification as the only carbon source. Detoxification of hydrolyzate using activated carbon was conducted ...
2014 / Rasika L. Kudahettige-Nilsson, Jonas Helmerius, Robert T. Nilsson, Magnus Sjöblom, David B. Hodge, et al.