Chemical sciences topic list of research papers
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Synthesis, biological evaluation, X-ray molecular structure and molecular docking studies of RGD mimetics containing 6-amino-2,3-dihydroisoindolin-1-one fragment as ligands of integrin αIIbβ3
Abstract A series of novel RGD mimetics containing phthalimidine fragment was designed and synthesized. Their antiaggregative activity determined by Born’s method was shown to be due to inhibition of fibrinogen binding to αIIbβ3. Molecular docking...
2013 / Andrei A. Krysko, Georgiy V. Samoylenko, Pavel G. Polishchuk, Marina S. Fonari, Victor Ch. Kravtsov, et al. -
Oral exposure of Kunming mice to diisononyl phthalate induces hepatic and renal tissue injury through the accumulation of ROS. Protective effect of melatonin
Abstract Diisononyl phthalate (DINP) has been widely used in polyvinyl chloride (PVC) products and is ubiquitous as a substitute; however, its toxicity due to exposure remains to be determined. This study investigated the oxidative damage induced by ...
2014 / Ping Ma, Biao Yan, Qiang Zeng, Xudong Liu, Yang Wu, et al. -
Quantitative Structure Activity Relationship Studies of Topoisomerase I Inhibitors as Potent Antibreast Cancer Agents2013 / Supriya Singh, Sucheta Das, Anubhuti Pandey, Sarvesh Paliwal, Rajeev Singh
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NMR Studies into the Potential Interactions of Fullerene C 60 with Tetraphenylporphyrin and Some of Its Derivatives2010 / C. Obondi, A. A. Rodriguez
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Diarylthiophenes as inhibitors of the pore-forming protein perforin
Abstract Evolution from a furan-containing high-throughput screen (HTS) hit (1) resulted in isobenzofuran-1(3H)-one (2) as a potent inhibitor of the function of both isolated perforin protein and perforin delivered in situ by intact KHYG-1 NK cells. ...
2015 / Christian K. Miller, Kristiina M. Huttunen, William A. Denny, Jagdish K. Jaiswal, Annette Ciccone, et al. -
Bis{μ-1-[(2-oxidophenyl)iminomethyl]-2-naphtholato}bis[pyridinecopper(II)]2009 / Kai Liu, Guihua Liu, Zhiqiang Cao, Meiju Niu
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A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides
Abstract Background Human serum MUC1 peptide fragments bearing aberrant O-glycans are secreted from columnar epithelial cell surfaces and known as clinically important serum biomarkers for the epithelial carcinoma when a specific...
2013 / Takahiko Matsushita, Wataru Takada, Kota Igarashi, Kentaro Naruchi, Risho Miyoshi, et al. -
Quantification of anandamide, oleoylethanolamide and palmitoylethanolamide in rodent brain tissue using high performance liquid chromatography–electrospray mass spectroscopy
Abstract Reported concentrations for endocannabinoids and related lipids in biological tissues can vary greatly; therefore, methods used to quantify these compounds need to be validated. This report describes a method to quantify anandamide (AEA),...
2013 / Daniel J. Liput, Eleftheria Tsakalozou, Dana C. Hammell, Kalpana S. Paudel, Kimberly Nixon, et al. -
2-Aminoanilinium 2-chloroacetate2010 / A. Srinivasa Rao, Bharat Kumar Tripuramallu, Kishore Ravada, Samar K. Das
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Solvent–surface interactions between nanodiamond and ethanol studied with in situ infrared spectroscopy
ABSTRACT In situ Attenuated Total reflectance infrared (ATR IR) spectroscopy is used to study the interaction between ethanol vapour and oxidised nanodiamond (ND) surfaces. On initial exposure an amorphous multilayer of...
2015 / Georgiana A. Inel, Eleonora-Mihaela Ungureau, Thomas S. Varley, Meetal Hirani, Katherine B. Holt -
Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics
Abstract Neuroserpin (NS) is a serine protease inhibitor (SERPIN) involved in different neurological pathologies, including the Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB), related to the aberrant polymerization of NS mutants....
2014 / Rosina Noto, Maria Grazia Santangelo, Matteo Levantino, Antonio Cupane, Maria Rosalia Mangione, et al. -
Data standards can boost metabolomics research, and if there is a will, there is a way2015 / Philippe Rocca-Serra, Reza M. Salek, Masanori Arita, Elon Correa, Saravanan Dayalan, et al.
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Two-step nanoprecipitation for the production of protein-loaded PLGA nanospheres
Abstract One of the first methods to encapsulate drugs within polymer nanospheres was developed by Fessi and coworkers in 1989 and consisted of one-step nanoprecipitation based on solvent displacement. However, proteins are poorly encapsulated...
2012 / Moraima Morales-Cruz, Giselle M. Flores-Fernández, Myreisa Morales-Cruz, Elsie A. Orellano, José A. Rodriguez-Martinez, et al. -
ent-Atisane and ent-kaurane diterpenoids from Isodon rosthornii
Abstract A new ent-atisanoid (1) and three new ent-kauranoids (2-4) belonging to different types, along with four known compounds were isolated from Isodon rosthornii. Their structures were established by means of extensive spectroscopic analysis....
2013 / Rui Zhan, Xiao-Nian Li, Xue Du, Wei-Guang Wang, Ke Dong, et al. -
2-Amino-4,6-dimethylpyrimidine–anthranilic acid (1/1)2010 / Samuel Ebenezer, Packianathan Thomas Muthiah
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N -(2-Bromo-4-methylphenyl)-2-(5-methyl-2-phenylpyrazolo[1,5- a ]pyrimidin-7-yl)acetamide2013 / Ibtissam Bassoude, Sabine Berteina-Raboin, El Mokhtar Essassi, Gérald Guillaumet, Lahcen El Ammari
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Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs
Abstract Plants can metabolize the Fusarium mycotoxin deoxynivalenol (DON) by forming the masked mycotoxin deoxynivalenol-3-β-d-glucoside (D3G). D3G might be cleaved during digestion, thus increasing the total DON burden of an individual. Due to a...
2014 / Veronika Nagl, Bettina Woechtl, Heidi Elisabeth Schwartz-Zimmermann, Isabel Hennig-Pauka, Wulf-Dieter Moll, et al. -
Update on newborn dried bloodspot testing for cerebrotendinous xanthomatosis: An available high-throughput liquid-chromatography tandem mass spectrometry method
Abstract Background Cerebrotendinous xanthomatosis (CTX) is a rare genetic disorder of bile acid synthesis that can cause progressive neurological damage and premature death. Detection of CTX in the newborn period would be...
2016 / Lisa Bleyle, Hidde H. Huidekoper, Frederic M. Vaz, Renu Singh, Robert D. Steiner, et al. -
Synthesis, characterization and mesomorphic properties of new symmetrical dimer liquid crystals derived from benzothiazole
Abstract Present works report the synthesis and characterization of a series of homologous symmetrical dimers α,ω-bis[4-(6′-methoxybenzothiazol-2′-yl)iminomethylphenoxy]alkane. Total of five members with different lengths of alkyl spacer groups of...
2015 / Kok-Leei Foo, Sie-Tiong Ha, Chien-Min Lin, Hong-Cheu Lin, Siew-Ling Lee, et al. -
N—H...N hydrogen bonding in 4,6-diphenyl-2-pyrimidinylamine isolated from the plant Justicia secunda (Acanthaceae)2004 / John F. Gallagher, Shyamaprosad Goswami, Baidyanath Chatterjee, Subrata Jana, Kalyani Dutta