Biological sciences topic list of research papers
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Optimizing hyaluronidase dose and plasmid DNA delivery greatly improves gene electrotransfer efficiency in rat skeletal muscle
Abstract Transfection of rat skeletal muscle in vivo is a widely used research model. However, gene electrotransfer protocols have been developed for mice and yield variable results in rats. We investigated whether changes in hyaluronidase...
2015 / Thorbjorn Akerstrom, Kenneth Vedel, Josefine Needham, Pernille Hojman, Eftychia Kontou, et al. -
Complete genome sequence of Rhodospirillum rubrum type strain (S1T)2011 / A. Christine Munk, Alex Copeland, Susan Lucas, Alla Lapidus, Tijana Glavina Del Rio, et al.
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Functional Characterization of Inflammatory Bowel Disease–Associated Gut Dysbiosis in Gnotobiotic Mice
Background & Aims Gut dysbiosis is closely involved in the pathogenesis of inflammatory bowel disease (IBD). However, it remains unclear whether IBD-associated gut dysbiosis contributes to disease pathogenesis or is merely secondary to...
2016 / Hiroko Nagao-Kitamoto, Andrew B. Shreiner, Merritt G. Gillilland, Sho Kitamoto, Chiharu Ishii, et al. -
Ghrelin and GHS-R1A signaling within the ventral and laterodorsal tegmental area regulate sexual behavior in sexually naïve male mice
Abstract In addition to food intake and energy balance regulation, ghrelin mediate the rewarding and motivational properties of palatable food as well as addictive drugs. The ability of ghrelin to regulate reinforcement involves the...
2015 / Luna Prieto-Garcia, Emil Egecioglu, Erik Studer, Lars Westberg, Elisabet Jerlhag -
Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats
Abstract Bortezomib, an effective anticancer drug for multiple myeloma, often causes peripheral neuropathy which is mainly characterized by numbness and painful paresthesia. Nevertheless, there is no effective strategy to escape or treat...
2015 / Shota Yamamoto, Takehiro Kawashiri, Hitomi Higuchi, Kuniaki Tsutsumi, Soichiro Ushio, et al. -
Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP222016 / Mingsheng Cai, Si Jiang, Zhancheng Zeng, Xiaowei Li, Chuncong Mo, et al.
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Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus
Summary Brain-derived neurotrophic factor (BDNF) plays a key role in energy balance. In population studies, SNPs of the BDNF locus have been linked to obesity, but the mechanism by which these variants cause weight gain is unknown. Here, we examined ...
2015 / Zongyang Mou, Thomas M. Hyde, Barbara K. Lipska, Keri Martinowich, Peter Wei, et al. -
Cilia, calcium and the basis of left-right asymmetry2012 / Dominic P Norris
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Cyclic AMP Signaling through Epac Axis Modulates Human Hemogenic Endothelium and Enhances Hematopoietic Cell Generation
Summary Hematopoietic cells emerge from hemogenic endothelium in the developing embryo. Mechanisms behind human hematopoietic stem and progenitor cell development remain unclear. Using a human pluripotent stem cell differentiation model, we report...
2016 / Shobhit Saxena, Roger E. Rönn, Carolina Guibentif, Roksana Moraghebi, Niels-Bjarne Woods -
Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity
Summary In contrast to the class I phosphoinositide 3-kinases (PI3Ks), the organismal roles of the kinase activity of the class II PI3Ks are less clear. Here, we report that class II PI3K-C2β kinase-dead mice are viable and healthy but display an...
2015 / Samira Alliouachene, Benoit Bilanges, Gaëtan Chicanne, Karen E. Anderson, Wayne Pearce, et al. -
Can sibling species of the Drosophila willistoni subgroup be recognized through combined microscopy techniques?2015 / Rebeca Zanini, Maríndia Deprá, Vera Lúcia da Silva Valente
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Dietary administration of diquat for 13 weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice
Abstract Male and female C57BL/6J mice were administered diquat dibromide (DQ∙Br2) in their diets at concentrations of 0 (control), 12.5 and 62.5 ppm for 13 weeks to assess the potential effects of DQ on the nigrostriatal dopaminergic system....
2015 / Daniel J. Minnema, Kim Z. Travis, Charles B. Breckenridge, Nicholas C. Sturgess, Mark Butt, et al. -
Generation of KCL025 research grade human embryonic stem cell line carrying a mutation in NF1 gene
Abstract The KCL025 human embryonic stem cell line was derived from an embryo donated for research that carried an autosomal dominant mutation in the NF1 gene encoding neurofibromin (c.3739–3742 ΔTTTG). Mutations in this gene have been linked to...
2016 / Heema Hewitson, Victoria Wood, Neli Kadeva, Glenda Cornwell, Stefano Codognotto, et al. -
Analytical sequence to study G-CSF effect on the transcriptome of isolated spinal motoneurons from SOD1 G93A mice, an animal model for amyotrophic lateral sclerosis
Abstract Granulocyte-colony stimulating factor (G-CSF) has been recently identified as a neurotrophic factor able to preserve motor functions, rescue motor units and extent survival in an animal model of amyotrophic lateral sclerosis, the SOD1 G93A...
2015 / Alexandre Henriques, Stefan Kastner, Oliver Wafzig, Jose-Luis Gonzalez De Aguilar, Armin Schneider -
Dicing with dogma: de-branching the lamellipodium
The primary event in the movement of a migrating eukaryotic cell is the extension of cytoplasmic sheets termed lamellipodia composed of networks of actin filaments. Lamellipodia networks are thought to arise through the branching of new filaments from the sides of ...
2010 / J. Victor Small -
A multivariate partial least squares approach to joint association analysis for multiple correlated traits
Abstract Many complex traits are highly correlated rather than independent. By taking the correlation structure of multiple traits into account, joint association analyses can achieve both higher statistical power and more accurate estimation. To...
2015 / Yang Xu, Wenming Hu, Zefeng Yang, Chenwu Xu -
Allele-specific transcription factor binding in liver and cervix cells unveils many likely drivers of GWAS signals
Abstract Genome-wide association studies (GWAS) point to regions with associated genetic variants but rarely to a specific gene and therefore detailed knowledge regarding the genes contributing to complex traits and diseases remains elusive. The...
2016 / Marco Cavalli, Gang Pan, Helena Nord, Emelie Wallén Arzt, Ola Wallerman, et al. -
Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation
Abstract Objective A novel approach to regulate obesity-associated adipose inflammation may be through metabolic reprogramming of macrophages (MΦs). Broadly speaking, MΦs dependent on glucose are pro-inflammatory, classically...
2016 / Amy R. Johnson, Yuanyuan Qin, Alyssa J. Cozzo, Alex J. Freemerman, Megan J. Huang, et al. -
Binding and structural studies of the complexes of type 1 ribosome inactivating protein from Momordica balsamina with cytosine, cytidine, and cytidine diphosphate
Abstract The type 1 ribosome inactivating protein from Momordica balsamina (MbRIP1) has been shown to interact with purine bases, adenine and guanine of RNA/DNA. We report here the binding and structural studies of MbRIP1 with a pyrimidine base,...
2015 / Shavait Yamini, S.N. Pandey, Punit Kaur, Sujata Sharma, T.P. Singh -
Do more intelligent brains retain heightened plasticity for longer in development? A computational investigation
Abstract Twin studies indicate that the heritability of general cognitive ability – the genetic contribution to individual differences – increases with age. Brant et al. (2013) reported that this increase in heritability occurs earlier in...
2016 / Michael S.C. Thomas