Biological sciences topic list of research papers
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Complete genome sequence of Acidaminococcus fermentans type strain (VR4T)2010 / Yun-Juan Chang, Rüdiger Pukall, Elizabeth Saunders, Alla Lapidus, Alex Copeland, et al.
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A cell-free system toward deciphering the post-translational modification barcodes of Oct4 in different cellular contexts
Abstract The octamer-binding transcription factor 4 (Oct4) is essential for maintaining the self-renewal and pluripotency of embryonic stem cells (ESCs). Post-translational modifications (PTMs) of Oct4 critically control its structure, function and...
2014 / Songsong Dan, Bo Kang, Xiaotao Duan, Ying-Jie Wang -
High frequency of human papillomavirus type 53 in oral cavity of asymptomatic HIV-infected people2015 / Carolina Oliveira Silva, Larissa Silva Santos, Olga Maria Diniz Pereira, Kátia Martins Lopes Azevedo, Ledy Horto Santos Oliveira
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Macronutrient balance mediates the growth of sexually selected weapons but not genitalia in male broad-horned beetles2015 / Clarissa M. House, Kim Jensen, James Rapkin, Sarah Lane, Kensuke Okada, et al.
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A method for analysis and design of metabolism using metabolomics data and kinetic models: Application on lipidomics using a novel kinetic model of sphingolipid metabolism
Abstract We present a model-based method, designated Inverse Metabolic Control Analysis (IMCA), which can be used in conjunction with classical Metabolic Control Analysis for the analysis and design of cellular metabolism. We demonstrate the...
2016 / Georgios Savoglidis, Aline Xavier da Silveira dos Santos, Isabelle Riezman, Paolo Angelino, Howard Riezman, et al. -
Glycosylation is an Androgen-Regulated Process Essential for Prostate Cancer Cell Viability
Abstract Steroid androgen hormones play a key role in the progression and treatment of prostate cancer, with androgen deprivation therapy being the first-line treatment used to control cancer growth. Here we apply a novel search strategy to identify ...
2016 / Jennifer Munkley, Daniel Vodak, Karen E. Livermore, Katherine James, Brian T. Wilson, et al. -
The effect of repeated stress on KCC2 and NKCC1 immunoreactivity in the hippocampus of female mice
Abstract K+–Cl− co-transporter (KCC2) and Na+–K+–2Cl− co-transporter (NKCC1) are the main regulators of neuronal intracellular chloride concentration; altered expression patterns of KCC2 and NKCC1 have been reported in several neurodegenerative...
2016 / Takao Tsukahara, Masaaki Masuhara, Haruki Iwai, Takahiro Sonomura, Tomoaki Sato -
Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells
Abstract Metabotropic glutamate receptor 4 (mGluR4) possesses immune modulatory properties in vivo, such that a positive allosteric modulator (PAM) of the receptor confers protection on mice with relapsing-remitting experimental autoimmune...
2015 / Claudia Volpi, Giada Mondanelli, Maria T. Pallotta, Carmine Vacca, Alberta Iacono, et al. -
Evolutionary potential in the Alpine: trait heritabilities and performance variation of the dwarf willowSalix herbaceafrom different elevations and microhabitats2016 / Janosch Sedlacek, Andrés J. Cortés, Julia Wheeler, Oliver Bossdorf, Guenter Hoch, et al.
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Genome-wide epigenetic cross-talk between DNA methylation and H3K27me3 in zebrafish embryos
Abstract DNA methylation and histone modifications are epigenetic marks implicated in the complex regulation of vertebrate embryogenesis. The cross-talk between DNA methylation and Polycomb-dependent H3K27me3 histone mark has been reported in a...
2015 / Elisa de la Calle Mustienes, Jose Luis Gómez-Skarmeta, Ozren Bogdanović -
Disease, Models, Variants and Altered Pathways—Journeying RGD Through the Magnifying Glass
Abstract Understanding the pathogenesis of disease is instrumental in delineating its progression mechanisms and for envisioning ways to counteract it. In the process, animal models represent invaluable tools for identifying disease-related loci and ...
2015 / Victoria Petri, G. Thomas Hayman, Marek Tutaj, Jennifer R. Smith, Stan Laulederkind, et al. -
Mitochondrial OXA Translocase Plays a Major Role in Biogenesis of Inner-Membrane Proteins
Summary The mitochondrial inner membrane harbors three protein translocases. Presequence translocase and carrier translocase are essential for importing nuclear-encoded proteins. The oxidase assembly (OXA) translocase is required for exporting...
2016 / Sebastian B. Stiller, Jan Höpker, Silke Oeljeklaus, Conny Schütze, Sandra G. Schrempp, et al. -
Temporally degradable collagen–mimetic hydrogels tuned to chondrogenesis of human mesenchymal stem cells
Abstract Tissue engineering strategies for repairing and regenerating articular cartilage face critical challenges to recapitulate the dynamic and complex biochemical microenvironment of native tissues. One approach to mimic the biochemical...
2016 / Paresh A. Parmar, Stacey C. Skaalure, Lesley W. Chow, Jean-Philippe St-Pierre, Violet Stoichevska, et al. -
DNA cytosine hydroxymethylation levels are distinct among non-overlapping classes of peripheral blood leukocytes
Abstract Background Peripheral blood leukocytes are the most commonly used surrogates to study epigenome-induced risk and epigenomic response to disease-related stress. We considered the hypothesis that the various classes of...
2016 / Natalie M. Hohos, Kevin Lee, Lexiang Ji, Miao Yu, Muthugapatti M. Kandasamy, et al. -
Compensatory embryonic response to allele-specific inactivation of the murine X-linked gene Hcfc1
Abstract Early in female mammalian embryonic development, cells randomly inactivate one of the two X chromosomes to achieve overall equal inactivation of parental X-linked alleles. Hcfc1 is a highly conserved X-linked mouse gene that encodes HCF-1 — ...
2016 / Shilpi Minocha, Tzu-Ling Sung, Dominic Villeneuve, Fabienne Lammers, Winship Herr -
Insecticide susceptibility in larval populations of the West Nile vector Culex pipiens L. (Diptera: Culicidae) in Saudi Arabia
Abstract Objective To investigate the susceptibility to some conventional and non-conventional insecticides in laboratory and field larval populations of the West Nile vector Culex pipiens L. (Cx. pipiens), the dominant species in...
2016 / Al Thabiani Aziz, Jazem Abdullah Mahyoub, Hasibur Rehman, Shalini Saggu, Kadarkarai Murugan, et al. -
Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder
Abstract From 106 human blastocyts donate for research after in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) for monogenetic disorder, 3 human embryonic stem cells (hESCs) HVR1, HVR2 and HVR3 were successfully derived. HVR1...
2016 / Abdelkrim Hmadcha, Yolanda Aguilera, Maria Dolores Lozano-Arana, Nuria Mellado, Javier Sánchez, et al. -
How many TCR clonotypes does a body maintain?
Abstract We consider the lifetime of a T cell clonotype, the set of T cells with the same T cell receptor, from its thymic origin to its extinction in a multiclonal repertoire. Using published estimates of total cell numbers and thymic production...
2015 / Grant Lythe, Robin E. Callard, Rollo L. Hoare, Carmen Molina-París -
Self-assembly formed by a short DNA probe pair: Application for highly sensitive mRNA species detection without reverse transcription
Abstract We describe a novel technology for detecting nucleic acids: Probe Alteration Link Self-Assembly Reactions (PALSAR). PALSAR comprises DNA self-assembly of pairs of short DNA probes formed by alternate hybridization of three complementary...
2015 / Mitsugu Usui, Toshihiko Fujikawa, Masako Osawa, Chikako Hakii, Natsumi Ikumi, et al. -
Data in support of a functional analysis of splicing mutations in the IDS gene and the use of antisense oligonucleotides to exploit an alternative therapy for MPS II
Abstract This data article contains insights into the methodology used for the analysis of three exonic mutations altering the splicing of the IDS gene: c.241C>T, c.257C>T and c.1122C>T. We have performed splicing assays...
2015 / Liliana Matos, Vânia Gonçalves, Eugénia Pinto, Francisco Laranjeira, Maria João Prata, et al.