Biological sciences topic list of research papers
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A novel role for 12/15-lipoxygenase in regulating autophagy
Abstract 12/15-Lipoxygenase (LOX) enzymatically generates oxidized phospholipids in monocytes and macrophages. Herein, we show that cells deficient in 12/15-LOX contain defective mitochondria and numerous cytoplasmic vacuoles containing electron...
2014 / Alwena H. Morgan, Victoria J. Hammond, Machiko Sakoh-Nakatogawa, Yoshinori Ohsumi, Christopher P. Thomas, et al. -
A Novel Phospholipase A 2 (D49) from the Venom of the Crotalus oreganus abyssus (North American Grand Canyon Rattlesnake)2014 / W. Martins, P. A. Baldasso, K. M. Honório, V. G. Maltarollo, R. I. M. A. Ribeiro, et al.
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Importance of reference gene selection for articular cartilage mechanobiology studies
Summary Objective Identification of genes differentially expressed in mechano-biological pathways in articular cartilage provides insight into the molecular mechanisms behind initiation and/or progression of osteoarthritis (OA)....
2015 / A. Al-Sabah, P. Stadnik, S.J. Gilbert, V.C. Duance, E.J. Blain -
Pulmonary delivery of DNA vaccine constructs using deacylated PEI elicits immune responses and protects against viral challenge infection
Abstract Vaccination through mucosal surfaces has been shown to elicit antiviral immune responses against a number of mucosal pathogens. Here we demonstrate that both mucosal and systemic immune responses can be elicited against a model HIV-1...
2013 / Jamie F.S. Mann, Paul F. McKay, Samantha Arokiasamy, Reeyeshkumar K. Patel, Katja Klein, et al. -
Autologous bone marrow stromal cells are promising candidates for cell therapy approaches to treat bone degeneration in sickle cell disease2015 / Angélique Lebouvier, Alexandre Poignard, Laura Coquelin-Salsac, Julie Léotot, Yasuhiro Homma, et al.
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Quantitative Western ligand blotting reveals common patterns and differential features of IGFBP-fingerprints in domestic ruminant breeds and species
Abstract The insulin-like growth factor binding proteins (IGFBPs) are determinants of local IGF-effects and thus have an impact on growth and metabolism in vertebrate species. In farm animals, IGFBPs are associated with traits such as growth rate,...
2015 / Elisa Wirthgen, Christine Höflich, Marion Spitschak, Carina Helmer, Bodo Brand, et al. -
The human crystallin gene families2012 / Graeme Wistow
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Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations2012 / Ayşe Demirkan, Cornelia M. van Duijn, Peter Ugocsai, Aaron Isaacs, Peter P. Pramstaller, et al.
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Myogenic induction of adult and pluripotent stem cells using recombinant proteins
Abstract Met Activating Genetically Improved Chimeric Factor 1 (Magic-F1) is a human recombinant protein, derived from dimerization of the receptor-binding domain of hepatocyte growth factor. Previous experiments demonstrate that in transgenic mice, ...
2015 / Ilaria Perini, Ilaria Elia, Antonio Lo Nigro, Flavio Ronzoni, Emanuele Berardi, et al. -
Issue Information2014 /
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MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3
Summary Conquering obesity has become a major socioeconomic challenge. Here, we show that reduced expression of the miR-25-93-106b cluster, or miR-93 alone, increases fat mass and, subsequently, insulin resistance. Mechanistically, we discovered an...
2015 / Michele Cioffi, Mireia Vallespinos-Serrano, Sara M. Trabulo, Pablo Jose Fernandez-Marcos, Ashley N. Firment, et al. -
Using molecular tools to guide management of invasive alien species: assessing the genetic impact of a recently introduced island bird population2015 / J. van de Crommenacker, Y. X. C. Bourgeois, B. H. Warren, H. Jackson, F. Fleischer-Dogley, et al.
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The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
Summary Background A high circulating concentration of interleukin 6 is associated with increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a monoclonal antibody (tocilizumab) licensed for...
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Intermedin protects against renal ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress2015 / Yanhong Wang, Jihua Tian, Xi Qiao, Xiaole Su, Yang Mi, et al.
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Approaches to defining a planetary boundary for biodiversity
Abstract The idea that there is an identifiable set of boundaries, beyond which anthropogenic change will put the Earth system outside a safe operating space for humanity, is attracting interest in the scientific community and gaining support in the ...
2014 / Georgina M. Mace, Belinda Reyers, Rob Alkemade, Reinette Biggs, F. Stuart Chapin, et al. -
Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress
Abstract Heat shock proteins (HSPs), originally identified as heat-inducible gene products, are a family of highly conserved proteins that respond to a wide variety of stress including oxidative stress. Although both acute and chronic oxidative...
2014 / Niku K.J. Oksala, F. Güler Ekmekçi, Ergi Özsoy, Şerife Kirankaya, Tarja Kokkola, et al. -
Acute liver injury induced by low dose dimethylnitrosamine alters mediators of hepatic vascular flow
Abstract Alterations in liver vascular tone play an important role in chronic liver disease. The hepatic stellate cell (HSC) and mediators such as nitric oxide (NO) and hydrogen sulfide (H2S) have been implicated in regulation of vascular tone and...
2014 / G. Jayakumar Amirtharaj, Kavitha R. Thangaraj, Archana Kini, Raghupathy V., Ashish Goel, et al. -
Establishment of induced pluripotent stem cell (iPSC) line from a 75-year old patient with late onset Alzheimer's disease (LOAD)
Abstract Peripheral blood mononuclear cells (PBMCs) were collected from a clinically characterised 75-year old woman with late onset Alzheimer's disease (LOAD). The PMBCs were reprogrammed with the human OSKM transcription factors using the...
2016 / Zsuzsanna Táncos, Eszter Varga, Eszter Kovács, András Dinnyés, Julianna Kobolák -
The use of the carbon/nitrogen ratio and specific organic loading rate as tools for improving biohydrogen production in fixed-bed reactors
Abstract This study assessed the effect of the carbon/nitrogen (C/N) ratio on the hydrogen production from sucrose-based synthetic wastewater in upflow fixed-bed anaerobic reactors. C/N ratios of 40, 90, 140, and 190 (gC/gN) were studied using...
2014 / Mélida del Pilar Anzola-Rojas, Samantha Gonçalves da Fonseca, Cynthia Canedo da Silva, Valeria Maia de Oliveira, Marcelo Zaiat -
CETP TaqIB genotype modifies the association between alcohol and coronary heart disease: The INTERGENE case-control study
Abstract Alcohol consumption at moderate levels has been associated with decreased risk of coronary heart disease (CHD). However, the cardio-protective effect of alcohol may be restricted to subjects with a particular genotype of the cholesteryl...
2014 / Kirsten Mehlig, Elisabeth Strandhagen, Per-Arne Svensson, Annika Rosengren, Kjell Torén, et al.