Biological sciences topic list of research papers
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A myostatin inhibitor (propeptide-Fc) increases muscle mass and muscle fiber size in aged mice but does not increase bone density or bone strength
Abstract Loss of muscle and bone mass with age are significant contributors to falls and fractures among the elderly. Myostatin deficiency is associated with increased muscle mass in mice, dogs, cows, sheep and humans, and mice lacking myostatin...
2013 / Phonepasong Arounleut, Peter Bialek, Li-Fang Liang, Sunil Upadhyay, Sadanand Fulzele, et al. -
Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes2011 / Paul Arora, Bibiana Garcia-Bailo, Zari Dastani, Darren Brenner, Andre Villegas, et al.
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Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain
Abstract Genome-wide association studies have nominated many genetic variants for common human traits, including diseases, but in many cases the underlying biological reason for a trait association is unknown. Subsets of genetic polymorphisms show a ...
2012 / Dena G. Hernandez, Mike A. Nalls, Matthew Moore, Sean Chong, Allissa Dillman, et al. -
Wild waterfowl migration and domestic duck density shape the epidemiology of highly pathogenic H5N8 influenza in the Republic of Korea
Abstract Highly pathogenic avian influenza (HPAI) viruses threaten human and animal health yet their emergence is poorly understood, partly because sampling of the HPAI Asian-origin H5N1 lineage immediately after its identification in 1996 was...
2015 / Sarah C. Hill, Youn-Jeong Lee, Byung-Min Song, Hyun-Mi Kang, Eun-Kyoung Lee, et al. -
Neu1 sialidase and matrix metalloproteinase-9 cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 and -9 activation, cellular signaling and pro-inflammatory responses
Abstract The precise mechanism(s) by which intracellular TOLL-like receptors (TLRs) become activated by their ligands remains unclear. Here, we report a molecular organizational G-protein coupled receptor (GPCR) signaling platform to potentiate a...
2013 / Samar Abdulkhalek, Myron R. Szewczuk -
Discovery-Based Science Education: Functional Genomic Dissection in Drosophila by Undergraduate Researchers2005 / Jiong Chen, Gerald B. Call, Elsa Beyer, Chris Bui, Albert Cespedes, et al.
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Early Development of Network Oscillations in the Ferret Visual Cortex2017 / Yuhui Li, Chunxiu Yu, Zhe Charles Zhou, Iain Stitt, Kristin K. Sellers, et al.
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Pollinator-mediated selection on floral size and tube color in Linum pubescens : Can differential behavior and preference in different times of the day maintain dimorphism?2017 / Merav Lebel, Uri Obolski, Lilach Hadany, Yuval Sapir
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Intraindividual Behavioral Variability Predicts Foraging Outcome in a Beach-dwelling Jumping Spider2017 / James L. L. Lichtenstein, Gregory T. Chism, Ambika Kamath, Jonathan N. Pruitt
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Longitudinal Transcriptional Response of Glycosylation-Related Genes, Regulators, and Targets in Cancer Cell Lines Treated With 11 Antitumor Agents2017 / Julia Krushkal, Yingdong Zhao, Curtis Hose, Anne Monks, James H Doroshow, et al.
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Sterile inflammation – do innate lymphoid cell subsets play a role?2012 / Shane Russell
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Interleukin-3 plays dual roles in osteoclastogenesis by promoting the development of osteoclast progenitors but inhibiting the osteoclastogenic process
Abstract Interleukin (IL)-3, a multilineage hematopoietic growth factor, is implicated in the regulation of osteoclastogenesis. However, the role of IL-3 in osteoclastogenesis remains controversial; whereas early studies showed that IL-3 stimulates...
2013 / Huixian Hong, Zhenqi Shi, Ping Qiao, Hui Li, Erin M. McCoy, et al. -
Identification of QTL for adult-plant resistance to powdery mildew in Chinese wheat landrace Pingyuan 50
Abstract Powdery mildew caused by Blumeria graminis f. sp. tritici is one of the major wheat diseases worldwide. The Chinese wheat landrace Pingyuan 50 has shown adult-plant resistance (APR) to powdery mildew in the field for over 60years. To...
2014 / Muhammad Azeem Asad, Bin Bai, Caixia Lan, Jun Yan, Xianchun Xia, et al. -
The modified FACS calcein AM retention assay: A high throughput flow cytometer based method to measure cytotoxicity
Abstract Current methods to determine cellular cytotoxicity in vitro are hampered by background signals that are caused by auto-fluorescent target and effector cells and by non-specific cell death. We combined and adjusted existing cell viability...
2016 / M.A. Gillissen, E. Yasuda, G. de Jong, S.E. Levie, D. Go, et al. -
Assessment of common variability and expression quantitative trait loci for genome-wide associations for progressive supranuclear palsy
Abstract Progressive supranuclear palsy is a rare parkinsonian disorder with characteristic neurofibrillary pathology consisting of hyperphosphorylated tau protein. Common variation defining the microtubule associated protein tau gene (MAPT) H1...
2014 / Raffaele Ferrari, Mina Ryten, Roberto Simone, Daniah Trabzuni, Naiya Nicolaou, et al. -
Novel method to ascertain chromatin accessibility at specific genomic loci from frozen brain homogenates and laser capture microdissected defined cells
Abstract We describe a novel method for assessing the “open” or “closed” state of chromatin at selected locations within the genome. This method combines the use of Benzonase, which can digest DNA in the presence of actin, with quantitative...
2016 / Elaine Delvaux, Diego Mastroeni, Jennifer Nolz, Paul D. Coleman -
Genetic evaluation of mesenchymal stem cells by G-banded karyotyping in a Cell Technology Center
Abstract Objective To present the initial results of first three years of implementation of a genetic evaluation test for bone marrow-derived mesenchymal stem cells in a Cell Technology Center. ...
2014 / Tamara Borgonovo, Isadora May Vaz, Alexandra Cristina Senegaglia, Carmen Lucia Kuniyoshi Rebelatto, Paulo Roberto Slud Brofman -
Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord
Summary Menthol and other counterstimuli relieve itch, resulting in an antipruritic state that persists for minutes to hours. However, the neural basis for this effect is unclear, and the underlying neuromodulatory mechanisms are unknown. Previous...
2014 / Adam P. Kardon, Erika Polgár, Junichi Hachisuka, Lindsey M. Snyder, Darren Cameron, et al. -
A Purine Nucleotide Biosynthesis Enzyme Guanosine Monophosphate Reductase Is a Suppressor of Melanoma Invasion
Summary Melanoma is one of the most aggressive types of human cancers, and the mechanisms underlying melanoma invasive phenotype are not completely understood. Here, we report that expression of guanosine monophosphate reductase (GMPR), an enzyme...
2013 / Joseph A. Wawrzyniak, Anna Bianchi-Smiraglia, Wiam Bshara, Sudha Mannava, Jeff Ackroyd, et al. -
Identification of ZDHHC14 as a novel human tumour suppressor gene2014 / Marc Yeste-Velasco, Xueying Mao, Richard Grose, Sakunthala C Kudahetti, Dongmei Lin, et al.