Biological sciences topic list of research papers
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Development of Polypeptide-based Nanoparticles for Non-viral Delivery of CD22 RNA Trans-splicing Molecule as a New Precision Medicine Candidate Against B-lineage ALL
Abstract CD22ΔE12 has emerged as a driver lesion in the pathogenesis of pediatric B-lineage acute lymphoblastic leukemia (ALL) and a new molecular target for RNA therapeutics. Here we report a 43-gene CD22ΔE12 signature transcriptome that shows a...
2015 / Fatih M. Uckun, Lloyd G. Mitchell, Sanjive Qazi, Yang Liu, Nan Zheng, et al. -
Antimicrobial profiles of bacterial clinical isolates from the Gabonese National Laboratory of Public Health: data from routine activity
Summary Background The present study is one of the first to provide a picture of antimicrobial resistance for a range of bacteria and antimicrobial classes in Gabon, Central Africa. ...
2014 / Léonard Kouegnigan Rerambiah, Jean-Charles Ndong, Pauline Mbakob Mengue Massoua, Severin Medzegue, Médard Elisee-Ndam, et al. -
Genomic insights into the Ixodes scapularis tick vector of Lyme disease2016 / Monika Gulia-Nuss, Andrew B. Nuss, Jason M. Meyer, Daniel E. Sonenshine, R. Michael Roe, et al.
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Sexual maturation and fertility of mice exposed to triphenyltin during prepubertal and pubertal periods
Abstract This study investigated the effects of pre- and peripubertal exposure (PND 15–45) to triphenyltin hydroxide (TPT: 0, 1.875, 3.75, 7.5 and 15mg/kg bw/d po) on mouse sexual maturation and fertility. Half of the mice were euthanized on PND 46...
2014 / Marcia S. Campos Mello, Isabella F. Delgado, Ana Paula A. Favareto, Camila M.T. Lopes, Marcelo M. Batista, et al. -
The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations
Abstract Heterozygous and rare homozygous mutations in PRoline-Rich Transmembrane protein 2 (PRRT2) underlie a group of paroxysmal disorders including epilepsy, kinesigenic dyskinesia episodic ataxia and migraine. Most of the mutations lead to...
2016 / Caterina Michetti, Enrico Castroflorio, Ivan Marchionni, Nicola Forte, Bruno Sterlini, et al. -
Molecular Structures of Transcribing RNA Polymerase I
Summary RNA polymerase I (Pol I) is a 14-subunit enzyme that solely synthesizes pre-ribosomal RNA. Recently, the crystal structure of apo Pol I gave unprecedented insight into its molecular architecture. Here, we present three cryo-EM structures of...
2016 / Lucas Tafur, Yashar Sadian, Niklas A. Hoffmann, Arjen J. Jakobi, Rene Wetzel, et al. -
Trypanosoma rangeli interactions within the vector Rhodnius prolixus: a mini review2006 / Patrícia Azambuja, Eloi S Garcia
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Changes in the hemagglutinin of H5N1 viruses during human infection – Influence on receptor binding
Abstract As avian influenza A(H5N1) viruses continue to circulate in Asia and Africa, global concerns of an imminent pandemic persist. Recent experimental studies suggest that efficient transmission between humans of current H5N1 viruses only...
2013 / Martin Crusat, Junfeng Liu, Angelina S. Palma, Robert A. Childs, Yan Liu, et al. -
Antimicrobial and Antioxidative Activities of Bioactive Constituents from Hydnophytum formicarum Jack.2008 / Supaluk Prachayasittikul, Prasit Buraparuangsang, Apilak Worachartcheewan, Chartchalerm Isarankura-Na-Ayudhya, Somsak Ruchirawat, et al.
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(S)-5-ethynyl-anabasine, a novel compound, is a more potent agonist than other nicotine alkaloids on the nematode Asu-ACR-16 receptor
Abstract Nematode parasites infect ∼2 billion people world-wide. Infections are treated and prevented by anthelmintic drugs, some of which act on nicotinic acetylcholine receptors (nAChRs). There is an unmet need for novel therapeutic agents because ...
2016 / Fudan Zheng, Xiangwei Du, Tsung-Han Chou, Alan P. Robertson, Edward W. Yu, et al. -
Phylogenetic relationships of Leishmania species based on trypanosomatid barcode (SSU rDNA) and gGAPDH genes: Taxonomic revision of Leishmania (L.) infantum chagasi in South America
Abstract Phylogenetic studies on trypanosomatid barcode using V7V8 SSU rRNA and gGAPDH gene sequences have provided support for redefining some trypanosomatid species and positioning new isolates. The genus Leishmania is a slow evolving monophyletic ...
2014 / Arlei Marcili, Marcia Ap. Sperança, Andrea P. da Costa, Maria de F. Madeira, Herbert S. Soares, et al. -
Functional Characterization and Categorization of Missense Mutations that Cause Methylmalonyl-CoA Mutase (MUT) Deficiency2014 / Patrick Forny, D. Sean Froese, Terttu Suormala, Wyatt W. Yue, Matthias R. Baumgartner
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Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia2016 / Mihovil Mladinov, Goran Sedmak, Heidi R. Fuller, Mirjana Babić Leko, Davor Mayer, et al.
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Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease
Abstract Mouse embryonic stem cell (mESC) lines were derived by crossing heterozygous transgenic (tg) mice expressing green fluorescent protein (GFP) under the control of the rat tyrosine hydroxylase (TH) promoter, with homozygous alpha-synuclein...
2016 / Margarita Chumarina, Carla Azevedo, Julie Bigarreau, Clémentine Vignon, Kwang-Soo Kim, et al. -
Glucocorticoid affects dendritic transport of BDNF-containing vesicles2015 / Naoki Adachi, Tadahiro Numakawa, Shingo Nakajima, Masashi Fukuoka, Haruki Odaka, et al.
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Generation of KCL016 research grade human embryonic stem cell line carrying a mutation in VHL gene
Abstract The KCL016 human embryonic stem cell line was derived from an embryo donated for research that carried an autosomal dominant mutation affecting splicing site of the VHL gene encoding von Hippel–Lindau tumor suppressor E3 ubiquitin protein...
2015 / Cristian Miere, Heema Hewitson, Victoria Wood, Neli Kadeva, Glenda Cornwell, et al. -
GADD45a physically and functionally interacts with TET1
Abstract DNA demethylation plays a central role during development and in adult physiology. Different mechanisms of active DNA demethylation have been established. For example, Growth Arrest and DNA Damage 45-(GADD45) and Ten-Eleven-Translocation...
2015 / Sabine Kienhöfer, Michael U. Musheev, Ulrike Stapf, Mark Helm, Lars Schomacher, et al. -
Parathyroid hormone induces adipocyte lipolysis via PKA-mediated phosphorylation of hormone-sensitive lipase
Abstract Parathyroid hormone (PTH) is secreted from the parathyroid glands in response to low plasma calcium levels. Besides its classical actions on bone and kidney, PTH may have other important effects, including metabolic effects, as suggested...
2015 / Sara Larsson, Helena A. Jones, Olga Göransson, Eva Degerman, Cecilia Holm -
Neutralizing Monoclonal Antibodies Block Chikungunya Virus Entry and Release by Targeting an Epitope Critical to Viral Pathogenesis
Summary We evaluated the mechanism by which neutralizing human monoclonal antibodies inhibit chikungunya virus (CHIKV) infection. Potently neutralizing antibodies (NAbs) blocked infection at multiple steps of the virus life cycle, including entry...
2015 / Jing Jin, Nathan M. Liss, Dong-Hua Chen, Maofu Liao, Julie M. Fox, et al. -
High salmon density and low discharge create periodic hypoxia in coastal rivers2017 / Christopher J. Sergeant, J. Ryan Bellmore, Casey McConnell, Jonathan W. Moore