Biological sciences topic list of research papers
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Unambiguous determination of Plasmodium vivax reticulocyte invasion by flow cytometry
Abstract The invasion of CD71+ reticulocytes by Plasmodium vivax is a crucial yet poorly characterised event. The application of flow cytometry to ex vivo invasion assays promises to facilitate the quantitative analysis of P. vivax reticulocyte...
2015 / Jee-Sun Cho, Bruce Russell, Varakorn Kosasaivee, Rou Zhang, Yves Colin, et al. -
A novel immunoproteomics method for identifying in vivo-induced Campylobacter jejuni antigens using pre-adsorbed sera from infected patients
Abstract Background Campylobacter jejuni is an important food-borne and zoonotic pathogen with a worldwide distribution. Humans and chickens are hosts of this pathogen. At present, there is no ideal vaccine...
2013 / Yuanqing Hu, Yuwei Shang, Jinlin Huang, Yan Wang, Fangzhe Ren, et al. -
Haploinsufficiency of a Spliceosomal GTPase Encoded by EFTUD2 Causes Mandibulofacial Dysostosis with Microcephaly
Mandibulofacial dysostosis with microcephaly (MFDM) is a rare sporadic syndrome comprising craniofacial malformations, microcephaly, developmental delay, and a recognizable dysmorphic appearance. Major sequelae, including choanal atresia, sensorineural hearing...
2012 / Matthew A. Lines, Lijia Huang, Jeremy Schwartzentruber, Stuart L. Douglas, Danielle C. Lynch, et al. -
Achievements and prospects of genomics-assisted breeding in three legume crops of the semi-arid tropics
Abstract Advances in next-generation sequencing and genotyping technologies have enabled generation of large-scale genomic resources such as molecular markers, transcript reads and BAC-end sequences (BESs) in chickpea, pigeonpea and groundnut, three ...
2013 / Rajeev K. Varshney, S. Murali Mohan, Pooran M. Gaur, N.V.P.R. Gangarao, Manish K. Pandey, et al. -
Regulation of Liver Metabolism by the Endosomal GTPase Rab5
Summary The liver maintains glucose and lipid homeostasis by adapting its metabolic activity to the energy needs of the organism. Communication between hepatocytes and extracellular environment via endocytosis is key to such homeostasis. Here, we...
2015 / Anja Zeigerer, Roman L. Bogorad, Kirti Sharma, Jerome Gilleron, Sarah Seifert, et al. -
Soluble CLEC2 Extracellular Domain Improves Glucose and Lipid Homeostasis by Regulating Liver Kupffer Cell Polarization
Abstract The polarization of tissue resident macrophages toward the alternatively activated, anti-inflammatory M2 phenotype is believed to positively impact obesity and insulin resistance. Here we show that the soluble form of the extracellular...
2015 / Xinle Wu, Jun Zhang, Hongfei Ge, Jamila Gupte, Helene Baribault, et al. -
Brucella ceti and Brucellosis in Cetaceans2012 / Caterina Guzmán-Verri, Rocío González-Barrientos, Gabriela Hernández-Mora, Juan-Alberto Morales, Elías Baquero-Calvo, et al.
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Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex
Summary Mitotic spindles are primarily composed of microtubules (MTs), generated by polymerization of α- and β-Tubulin hetero-dimers [1, 2]. Tubulins undergo a series of protein folding and post-translational modifications in order to fulfill their...
2015 / Valeria Palumbo, Claudia Pellacani, Kate J. Heesom, Kacper B. Rogala, Charlotte M. Deane, et al. -
p19INK4d Controls Hematopoietic Stem Cells in a Cell-Autonomous Manner during Genotoxic Stress and through the Microenvironment during Aging
Summary Hematopoietic stem cells (HSCs) are characterized by the capacity for self-renewal and the ability to reconstitute the entire hematopoietic compartment. Thrombopoietin maintains adult HSCs in a quiescent state through the induction of cell...
2014 / Morgane Hilpert, Céline Legrand, Dominique Bluteau, Natalie Balayn, Aline Betems, et al. -
Gene expression profiling of loss of TET2 and/or JAK2V617F mutant hematopoietic stem cells from mouse models of myeloproliferative neoplasms
Abstract Myeloproliferative neoplasms (MPNs) are clinically characterized by the chronic overproduction of differentiated peripheral blood cells and the gradual expansion of malignant intramedullary/extramedullary hematopoiesis. In MPNs mutations in ...
2015 / Takuro Kameda, Kotaro Shide, Takumi Yamaji, Ayako Kamiunten, Masaaki Sekine, et al. -
Investigating cellular network heterogeneity and modularity in cancer: a network entropy and unbalanced motif approach2016 / Feixiong Cheng, Chuang Liu, Bairong Shen, Zhongming Zhao
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Characterization of neurons from immortalized dental pulp stem cells for the study of neurogenetic disorders
Abstract A major challenge to the study and treatment of neurogenetic syndromes is accessing live neurons for study from affected individuals. Although several sources of stem cells are currently available, acquiring these involve invasive...
2015 / Nora Urraca, Rawaha Memon, Ikbale El-Iyachi, Sarita Goorha, Colleen Valdez, et al. -
Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex
Abstract Dissipating excess calories as heat through therapeutic stimulation of brown adipose tissues (BAT) has been proposed as a potential treatment for obesity-linked disorders. Here, we describe the generation of a humanized effector-less...
2015 / Ganesh Kolumam, Mark Z. Chen, Raymond Tong, Jose Zavala-Solorio, Lance Kates, et al. -
Increased Polyubiquitination and Proteasomal Degradation of a Munc18-1 Disease-Linked Mutant Causes Temperature-Sensitive Defect in Exocytosis
Summary Munc18-1 is a critical component of the core machinery controlling neuroexocytosis. Recently, mutations in Munc18-1 leading to the development of early infantile epileptic encephalopathy have been discovered. However, which degradative...
2014 / Sally Martin, Andreas Papadopulos, Vanesa M. Tomatis, Emma Sierecki, Nancy T. Malintan, et al. -
Microglial microvesicle secretion and intercellular signaling2012 / Elena Turola
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The substantial hospitalization burden of influenza in central China: surveillance for severe, acute respiratory infection, and influenza viruses, 2010-20122013 / Hongjie Yu, Jigui Huang, Yang Huai, Xuhua Guan, John Klena, et al.
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NEArender: an R package for functional interpretation of ‘omics’ data via network enrichment analysis2017 / Ashwini Jeggari, Andrey Alexeyenko
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Mechanistic understanding of nanoparticles’ interactions with extracellular matrix: the cell and immune system2017 / Ayse Basak Engin, Dragana Nikitovic, Monica Neagu, Petra Henrich-Noack, Anca Oana Docea, et al.
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Apicobasal Polarity Controls Lymphocyte Adhesion to Hepatic Epithelial Cells
Summary Loss of apicobasal polarity is a hallmark of epithelial pathologies. Leukocyte infiltration and crosstalk with dysfunctional epithelial barriers are crucial for the inflammatory response. Here, we show that apicobasal architecture regulates...
2014 / Natalia Reglero-Real, Adrián Álvarez-Varela, Eva Cernuda-Morollón, Jorge Feito, Beatriz Marcos-Ramiro, et al. -
Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species
Summary Here, we examine the mechanism by which plasmacytoid dendritic cells (pDCs) and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody...
2015 / Xinfang Huang, Jingjing Li, Stephanie Dorta-Estremera, Jeremy Di Domizio, Scott M. Anthony, et al.