Biological sciences topic list of research papers
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Microarray data and pathway analyses for primary human activated hepatic stellate cells compared to HepG2 human hepatoma cells
Abstract As nonalcoholic fatty liver disease progresses to end-stage diseases, including fibrosis, cirrhosis and hepatocellular carcinoma, fibrotic activated hepatic stellate cells and cancerous epithelial cells can become abundant, changing the...
2016 / Alexandra M. Hetherington, Cynthia G. Sawyez, Nica M. Borradaile -
IgG silencing induces apoptosis and suppresses proliferation, migration and invasion in LNCaP prostate cancer cells2016 / Yawen Xu, Binshen Chen, Shaobo Zheng, Yong Wen, Abai Xu, et al.
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Development of a human induced pluripotent stem cell (iPSC) line from a Parkinson's disease patient carrying the N551K variant in LRRK2 gene
Abstract Peripheral blood mononuclear cells (PBMCs) were collected from a clinically diagnosed 64-year old male Parkinson's disease (PD) patient with N551K variant in the LRRK2 gene. The PMBCs were reprogrammed with the human OSKM transcription...
2016 / Dongrui Ma, Ebonne Yulin Ng, Li Zeng, Christina Ying Yan Lim, Yi Zhao, et al. -
Aberrant developmental titin splicing and dysregulated sarcomere length in Thymosin β4 knockout mice
Abstract Sarcomere assembly is a highly orchestrated and dynamic process which adapts, during perinatal development, to accommodate growth of the heart. Sarcomeric components, including titin, undergo an isoform transition to adjust ventricular...
2016 / Nicola Smart, Johannes Riegler, Cameron W. Turtle, Craig A. Lygate, Debra J. McAndrew, et al. -
Primary Human Testicular Cells Self-Organize into Organoids with Testicular Properties
Summary So far, successful de novo formation of testicular tissue followed by complete spermatogenesis in vitro has been achieved only in rodents. Our findings reveal that primary human testicular cells are able to self-organize into human...
2016 / Yoni Baert, Joery De Kock, João P. Alves-Lopes, Olle Söder, Jan-Bernd Stukenborg, et al. -
Genetic identification of marine eels through DNA barcoding from Parangipettai coastal waters
Abstract Anguilliformes, also known as “true eels”, are an ecologically diverse group of predominantly marine origin whose members were easily recognized by their extremely elongated bodies with reduced cross-sectional areas and universal lack of...
2016 / Samuel Peninal, Janakiraman Subramanian, Alaganatham Elavarasi, Murugaiyan Kalaiselvam -
Isoflavone formononetin from red propolis acts as a fungicide against Candida sp2016 / Michelline Viviane Marques das Neves, Tânia Maria Sarmento da Silva, Edeltrudes de Oliveira Lima, Emídio Vasconcelos Leitão da Cunha, Eduardo de Jesus Oliveira
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Mutations in GDP-Mannose Pyrophosphorylase B Cause Congenital and Limb-Girdle Muscular Dystrophies Associated with Hypoglycosylation of α-Dystroglycan
Congenital muscular dystrophies with hypoglycosylation of α-dystroglycan (α-DG) are a heterogeneous group of disorders often associated with brain and eye defects in addition to muscular dystrophy. Causative variants in 14 genes thought to be involved in the...
2013 / Keren J. Carss, Elizabeth Stevens, A. Reghan Foley, Sebahattin Cirak, Moniek Riemersma, et al. -
Same-sex sexual behaviour as a dominance display
Same-sex sexual behaviour (SSB) is widespread across taxa. One adaptive hypothesis to explain the occurrence and maintenance of SSB is that it acts to intensify or diminish aggression by providing males with a means to reinforce or resolve dominance. However,...
2016 / Sarah M. Lane, Alice E. Haughan, Daniel Evans, Tom Tregenza, Clarissa M. House -
NF-YA splice variants have different roles on muscle differentiation
Abstract The heterotrimeric CCAAT-binding factor NF-Y controls the expression of a multitude of genes involved in cell cycle progression. NF-YA is present in two alternatively spliced isoforms, NF-YAs and NF-YAl, differing in 28 aminoacids in the...
2016 / Valentina Basile, Fiorenza Baruffaldi, Diletta Dolfini, Silvia Belluti, Paolo Benatti, et al. -
Hung Out to Dry: Choice of Priority Ecoregions for Conserving Threatened Neotropical Anurans Depends on Life-History Traits2008 / Rafael Dias Loyola, Carlos Guilherme Becker, Umberto Kubota, Célio Fernando Baptista Haddad, Carlos Roberto Fonseca, et al.
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MAP3K11/GDF15 axis is a critical driver of cancer cachexia2015 / Lorena Lerner, Julie Tao, Qing Liu, Richard Nicoletti, Bin Feng, et al.
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Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo
Abstract The effect of acute inhibition of both mTORC1 and mTORC2 on metabolism is unknown. A single injection of the mTOR kinase inhibitor, AZD8055, induced a transient, yet marked increase in fat oxidation and insulin resistance in mice, whereas...
2014 / Maximilian Kleinert, Lykke Sylow, Daniel J. Fazakerley, James R. Krycer, Kristen C. Thomas, et al. -
3D hybrid modelling of vascular network formation
Abstract We develop an off-lattice, agent-based model to describe vasculogenesis, the de novo formation of blood vessels from endothelial progenitor cells during development. The endothelial cells that comprise our vessel network are viewed as...
2016 / Holger Perfahl, Barry D. Hughes, Tomás Alarcón, Philip K. Maini, Mark C. Lloyd, et al. -
Medial and Lateral Entorhinal Cortex Differentially Excite Deep versus Superficial CA1 Pyramidal Neurons
Summary Although hippocampal CA1 pyramidal neurons (PNs) were thought to comprise a uniform population, recent evidence supports two distinct sublayers along the radial axis, with deep neurons more likely to form place cells than superficial...
2017 / Arjun V. Masurkar, Kalyan V. Srinivas, David H. Brann, Richard Warren, Daniel C. Lowes, et al. -
Transcriptomes of bovine ovarian follicular and luteal cells
Abstract Affymetrix Bovine GeneChip® Gene 1.0 ST Array RNA expression analysis was performed on four somatic ovarian cell types: the granulosa cells (GCs) and theca cells (TCs) of the dominant follicle and the large luteal cells (LLCs) and small...
2016 / Sarah M. Romereim, Adam F. Summers, William E. Pohlmeier, Pan Zhang, Xiaoying Hou, et al. -
Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca 2+ influx2015 / Gusheng Wu, Zi-Hua Lu, Sabine André, Hans-Joachim Gabius, Robert W. Ledeen
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Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau2015 / Ce Xie, Yoshiyuki Soeda, Yuki Shinzaki, Yasuko In, Koji Tomoo, et al.
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Digging up the roots of an insular hotspot of genetic diversity: decoupled mito-nuclear histories in the evolution of the Corsican-Sardinian endemic lizard Podarcis tiliguerta2017 / Daniele Salvi, Catarina Pinho, D. James Harris
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Why do we differ in number sense? Evidence from a genetically sensitive investigation
Abstract Basic intellectual abilities of quantity and numerosity estimation have been detected across animal species. Such abilities are referred to as ‘number sense’. For human species, individual differences in number sense are detectable early in ...
2014 / M.G. Tosto, S.A. Petrill, J. Halberda, M. Trzaskowski, T.N. Tikhomirova, et al.