Biological sciences topic list of research papers
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Is the clinical use of adult stem cells a realistic possibility for myocardial regeneration?2008 / K. Kaczmarczyk
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Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells
Abstract A definitive cure for chronic myeloid leukemia (CML) requires identifying novel therapeutic targets to eradicate leukemia stem cells (LSCs). However, the rarity of LSCs within the primitive hematopoietic cell compartment remains a major...
2015 / Kran Suknuntha, Yuki Ishii, Lihong Tao, Kejin Hu, Brian E. McIntosh, et al. -
Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells
Summary Converging evidence indicates that microRNAs (miRNAs) may contribute to disease risk for schizophrenia (SZ). We show that microRNA-9 (miR-9) is abundantly expressed in control neural progenitor cells (NPCs) but also significantly...
2016 / Aaron Topol, Shijia Zhu, Brigham J. Hartley, Jane English, Mads E. Hauberg, et al. -
Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes
Summary Stem cell-derived somatic cells represent an unlimited resource for basic and translational science. Although promising, there are significant hurdles that must be overcome. Our focus is on the generation of the major cell type of the human...
2015 / Kate Cameron, Rosanne Tan, Wolfgang Schmidt-Heck, Gisela Campos, Marcus J. Lyall, et al. -
Recombinant low-seroprevalent adenoviral vectors Ad26 and Ad35 expressing the respiratory syncytial virus (RSV) fusion protein induce protective immunity against RSV infection in cotton rats
Abstract RSV is an important cause of lower respiratory tract infections in children, the elderly and in those with underlying medical conditions. Although the high disease burden indicates an urgent need for a vaccine against RSV, no licensed RSV...
2015 / Myra N. Widjojoatmodjo, Lies Bogaert, Bob Meek, Roland Zahn, Jort Vellinga, et al. -
Reduction of PCN biosynthesis by NO in Pseudomonas aeruginosa
Abstract Pyocyanin (PCN), a virulence factor synthesized by Pseudomonas aeruginosa, plays an important role during clinical infections. There is no study of the effect of nitric oxide (NO) on PCN biosynthesis. Here, the effect of NO on PCN levels in ...
2015 / Lei Gao, Yuying Zhang, Yan Wang, Xinhua Qiao, Jing Zi, et al. -
The functional interaction between abaecin and pore-forming peptides indicates a general mechanism of antibacterial potentiation
Abstract Long-chain proline-rich antimicrobial peptides such as bumblebee abaecin show minimal activity against Gram-negative bacteria despite binding efficiently to specific intracellular targets. We recently reported that bumblebee abaecin...
2016 / Mohammad Rahnamaeian, Małgorzata Cytryńska, Agnieszka Zdybicka-Barabas, Andreas Vilcinskas -
Complete genome sequence of the thermophilic sulfur-reducer Desulfurobacterium thermolithotrophum type strain (BSAT) from a deep-sea hydrothermal vent2012 / Markus Göker, Hajnalka Daligault, Romano Mwirichia, Alla Lapidus, Susan Lucas, et al.
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A mechanistic evaluation of the Syrian hamster embryo cell transformation assay (pH 6.7) and molecular events leading to senescence bypass in SHE cells
Abstract The implementation of the Syrian hamster embryo cell transformation assay (SHE CTA) into test batteries and its relevance in predicting carcinogenicity has been long debated. Despite prevalidation studies to ensure reproducibility and...
2016 / Jessica C. Pickles, Kamala Pant, Lisa A. Mcginty, Hemad Yasaei, Terry Roberts, et al. -
Comparison of two next-generation sequencing kits for diagnosis of epileptic disorders with a user-friendly tool for displaying gene coverage, DeCovA2015 / Sarra Dimassi, Thomas Simonet, Audrey Labalme, Nadia Boutry-Kryza, Amandine Campan-Fournier, et al.
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Temporal stability of parasite distribution and genetic variability values of Contracaecum osculatum sp. D and C. osculatum sp. E (Nematoda: Anisakidae) from fish of the Ross Sea (Antarctica)
Abstract The Ross Sea, Eastern Antarctica, is considered a “pristine ecosystem” and a biodiversity “hotspot” scarcely impacted by humans. The sibling species Contracaecum osculatum sp. D and C. osculatum sp. E are anisakid parasites embedded in the...
2015 / Simonetta Mattiucci, Paolo Cipriani, Michela Paoletti, Valentina Nardi, Mario Santoro, et al. -
Regulation of Arabidopsis root development by small signaling peptides2013 / Christina Delay, Nijat Imin, Michael A. Djordjevic
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OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition
Summary In development, embryonic ectoderm differentiates into neuroectoderm and surface ectoderm using poorly understood mechanisms. Here, we show that the transcription factor OVOL2 maintains the transcriptional program of human corneal epithelium ...
2016 / Koji Kitazawa, Takafusa Hikichi, Takahiro Nakamura, Kanae Mitsunaga, Azusa Tanaka, et al. -
Cyclophilin A modulates bone marrow-derived CD117+ cells and enhances ischemia-induced angiogenesis via the SDF-1/CXCR4 axis
Abstract Background Critical limb ischemia (CLI) is a major health problem with no adequate treatment. Since CLI is characterized by insufficient tissue vascularization, efforts have focused on the discovery of novel angiogenic...
2016 / Gianluca L. Perrucci, Stefania Straino, Maria Corlianò, Alessandro Scopece, Monica Napolitano, et al. -
Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice
Summary Trypanosoma brucei is an extracellular parasite that causes sleeping sickness. In mammalian hosts, trypanosomes are thought to exist in two major niches: early in infection, they populate the blood; later, they breach...
2016 / Sandra Trindade, Filipa Rijo-Ferreira, Tânia Carvalho, Daniel Pinto-Neves, Fabien Guegan, et al. -
An HTRF based high-throughput screening for discovering chemical compounds that inhibit the interaction between Trypanosoma brucei Pex5p and Pex14p
Abstract The glycosome, a peroxisome-related organelle, is essential for the growth and survival of trypanosomatid protozoa. In glycosome biogenesis, Pex5p recognizes newly synthesized glycosomal matrix proteins via peroxisome-targeting signal...
2016 / Yuichi Watanabe, Kosuke Kawaguchi, Syuken Saito, Takayoshi Okabe, Kiyoaki Yonesu, et al. -
Dataset on the effects of CYB5D2 on the distribution of HeLa cervical cancer cell cycle
Abstract We have recently reported that CYB5D2 plays a role in suppression of cervical cancer tumorigenesis, “CYB5D2 displays tumor suppression activities towards cervical cancer” [1]. We provide the accompany data here describing the effects of...
2016 / Yanyun Xie, Yen Ting Shen, Anil Kapoor, Diane Ojo, Fengxiang Wei, et al. -
Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System
Summary Signal transducer and activator of transcription 3 (STAT3) is a transcription factor central to axon regrowth with an enigmatic ability to act in different subcellular regions independently of its transcriptional roles. However, its roles in ...
2016 / Xueting Luo, Marcio Ribeiro, Eric R. Bray, Do-Hun Lee, Benjamin J. Yungher, et al. -
Successful Treatment of Intracranial Glioblastoma Xenografts With a Monoamine Oxidase B-Activated Pro-Drug
Abstract The last major advance in the treatment of glioblastoma multiforme (GBM) was the introduction of temozolomide in 1999. Treatment with temozolomide following surgical debulking extends survival rate compared to radiotherapy and debulking...
2015 / Martyn A. Sharpe, Andrew D. Livingston, Taylor L. Gist, Pardip Ghosh, Junyan Han, et al. -
New hPSC-based human models to study pediatric Acute Megakaryoblastic Leukemia harboring the fusion oncogene RBM15-MKL1
Abstract Pediatric Acute Megakaryoblastic Leukemia not associated to Down Syndrome (non-DS AMKL) is a rare disease with a dismal prognosis. Around 15% of patients carry the chromosomal translocation t(1;22) that originates the fusion oncogene...
2016 / Verónica Ayllón, Marina Vogel-González, Federico González-Pozas, Joan Domingo-Reinés, Rosa Montes, et al.