Biological sciences topic list of research papers
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Characterization of an African trypanosome mutant refractory to lectin-induced death
Abstract Incubation of African trypanosomes with the lectin concanavalin A (conA) leads to alteration in cellular DNA content, DNA degradation, and surface membrane blebbing. Here, we report the generation and characterization of a conA-refractory...
2015 / Amber L. Hackler, Yijian Qiu, Stephen L. Patrick, Soo Hee Lee, Alvaro Acosta-Serrano, et al. -
A study of the osmotic characteristics, water permeability, and cryoprotectant permeability of human vaginal immune cells
Abstract Cryopreservation of specimens taken from the genital tract of women is important for studying mucosal immunity during HIV prevention trials. However, it is unclear whether the current, empirically developed cryopreservation procedures for...
2016 / Zhiquan Shu, Sean M. Hughes, Cifeng Fang, Jinghua Huang, Baiwen Fu, et al. -
Evaluating biomarkers to model cancer risk post cosmic ray exposure
Abstract Robust predictive models are essential to manage the risk of radiation-induced carcinogenesis. Chronic exposure to cosmic rays in the context of the complex deep space environment may place astronauts at high cancer risk. To estimate this...
2016 / Deepa M. Sridharan, Aroumougame Asaithamby, Steve R. Blattnig, Sylvain V. Costes, Paul W. Doetsch, et al. -
Data on antioxidant activity in grapevine (Vitis vinifera L.) following cryopreservation by vitrification
Abstract Cryopreservation is used for the long-term conservation of plant genetic resources. This technique very often induces lethal injury or tissue damage. In this study, we measured indicators of viability and cell damage following...
2015 / María Fernanda Lazo-Javalera, Martín Ernesto Tiznado-Hernández, Irasema Vargas-Arispuro, Elisa Valenzuela-Soto, María del Carmen Rocha-Granados, et al. -
Novel cell-based in vitro screen to identify small-molecule inhibitors against intracellular replication of Cryptococcus neoformans in macrophages
Abstract The fungal pathogen Cryptococcus neoformans poses a major threat to immunocompromised patients and is a leading killer of human immunodeficiency virus (HIV)-infected patients worldwide. Cryptococci are known to manipulate host macrophages...
2016 / Sweta Samantaray, Joao N. Correia, Mariam Garelnabi, Kerstin Voelz, Robin C. May, et al. -
Generation of a heterozygous knockout human embryonic stem cell line for the OCIAD1 locus using CRISPR/CAS9 mediated targeting: BJNhem20-OCIAD1-CRISPR-20
Abstract Ovarian carcinoma immuno-reactive antigen domain containing 1(OCIAD1) single copy was knocked out generating an OCIAD1 heterozygous knockout human embryonic stem line named BJNhem20-OCIAD1-CRISPR-20. The line was generated using...
2016 / Deeti K. Shetty, Maneesha S. Inamdar -
Data on spermatogenesis in rat males gestationally exposed to bisphenol A and high fat diets
Abstract This data article contains supporting information regarding the research article entitled “High butter-fat diet and bisphenol A additively impair male rat spermatogenesis” (P. Tarapore, M. Hennessy, D. Song, J. Ying, B. Ouyang, V....
2016 / Pheruza Tarapore, Max Hennessy, Dan Song, Jun Ying, Bin Ouyang, et al. -
Efficacy and safety of rolapitant for prevention of chemotherapy-induced nausea and vomiting over multiple cycles of moderately or highly emetogenic chemotherapy
Abstract Objective Rolapitant, a novel neurokinin-1 receptor antagonist (RA), was shown to protect against delayed chemotherapy-induced nausea and vomiting (CINV) during the first cycle of moderately emetogenic chemotherapy (MEC)...
2016 / Bernardo Rapoport, Lee Schwartzberg, Martin Chasen, Dan Powers, Sujata Arora, et al. -
The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate
Summary The HECT domain E3 ligase HACE1 has been identified as a tumor suppressor in multiple cancers. Here, we report that HACE1 is a central gatekeeper of TNFR1-induced cell fate. Genetic inactivation of HACE1 inhibits TNF-stimulated NF-κB...
2016 / Luigi Tortola, Roberto Nitsch, Mathieu J.M. Bertrand, Melanie Kogler, Younes Redouane, et al. -
Role of CD73 in renal sympathetic neurotransmission in the mouse kidney2013 / Edwin K. Jackson, Dongmei Cheng, Zaichuan Mi, Jonathan D. Verrier, Keri Janesko-Feldman, et al.
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AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue
Abstract Objective Characterize the cellular and molecular events responsible for lipodystrophy in AGPAT2 deficient mice. Methods Adipose tissue and differentiated ...
2016 / Kelly M. Cautivo, Carlos O. Lizama, Pablo J. Tapia, Anil K. Agarwal, Abhimanyu Garg, et al. -
Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis
Abstract Osteoarthritis (OA) is a chronic degenerative joint disorder commonly associated with metabolic syndrome. As ageing and obesity has a great impact on the initiation/severity of OA, herein we sought to investigate the involvement of Sirt6 in ...
2015 / Maierhaba Ailixiding, Zulipiya Aibibula, Munetaka Iwata, Jinying Piao, Yasushi Hara, et al. -
Platelet-derived growth factor-BB has neurorestorative effects and modulates the pericyte response in a partial 6-hydroxydopamine lesion mouse model of Parkinson's disease
Abstract Parkinson's disease (PD) is a neurodegenerative disease where the degeneration of the nigrostriatal pathway leads to specific motor deficits. There is an unmet medical need for regenerative treatments that stop or reverse disease...
2016 / Thomas Padel, Ilknur Özen, Jordi Boix, Marco Barbariga, Abderahim Gaceb, et al. -
Complete genome sequence of Meiothermus silvanus type strain (VI-R2T)2010 / Johannes Sikorski, Brian J Tindall, Stephen Lowry, Susan Lucas, Matt Nolan, et al.
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Corynebacterium pseudotuberculosis RNA-seq data from abiotic stresses
Abstract Corynebacterium pseudotuberculosis causes significant loss to goat and sheep farmers because it is the causal agent of the infectious disease caseous lymphadenitis, which may lead to outcomes ranging from skin injury...
2015 / Pablo H.C.G. de Sá, Adonney A.O. Veras, Adriana R. Carneiro, Rafael A. Baraúna, Luís C. Guimarães, et al. -
Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice
Background & Aims Pancreatic stellate cells (PSCs) regulate the development of chronic pancreatitis (CP) and are activated by the cytokine transforming growth factor β (TGFB). Integrins of the αv family promote TGFB signaling in mice,...
2016 / Barbara Ulmasov, Brent A. Neuschwander-Tetri, Jinping Lai, Vladimir Monastyrskiy, Trisha Bhat, et al. -
Characterization and ex vivo Expansion of Human Placenta-Derived Natural Killer Cells for Cancer Immunotherapy2013 / Lin Kang, Vanessa Voskinarian-Berse, Eric Law, Tiffany Reddin, Mohit Bhatia, et al.
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Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data2016 / Adriana Goncalves, Pateh Makalo, Hassan Joof, Sarah Burr, Athumani Ramadhani, et al.
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The origin of HTLV-1 in southern Bahia by phylogenetic, mtDNA and β-globin analysis
Abstract Different hypotheses have been elaborated to explain how the HTLV spread throughout the world. It has been proposed that the virus was introduced in Bahia, during the slave-trade period from the 16th century to 19th century. However, there...
2015 / Milena Magalhães Aleluia, Marco Antônio Gomes Mello, Luiz Carlos Junior Alcântara, Filipe Ferreira Almeida Rego, Lucas Pereira de Souza Santos, et al. -
Novel pH-dependent regulation of human cytosolic sialidase 2 (NEU2) activities by siastatin B and structural prediction of NEU2/siastatin B complex
Abstract Human cytosolic sialidase (Neuraminidase 2, NEU2) catalyzes the removal of terminal sialic acid residues from glycoconjugates. The effect of siastatin B, known as a sialidase inhibitor, has not been evaluated toward human NEU2 yet. We...
2015 / M. Motiur Rahman, Takatsugu Hirokawa, Daisuke Tsuji, Jun Tsukimoto, Seiji Hitaoka, et al.