Biological sciences topic list of research papers
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Hepatic differentiation of human pluripotent stem cells in miniaturized format suitable for high-throughput screen
Abstract The establishment of protocols to differentiate human pluripotent stem cells (hPSCs) including embryonic (ESC) and induced pluripotent (iPSC) stem cells into functional hepatocyte-like cells (HLCs) creates new opportunities to study liver...
2016 / Arnaud Carpentier, Ila Nimgaonkar, Virginia Chu, Yuchen Xia, Zongyi Hu, et al. -
Evaluation of food-relevant chemicals in the ToxCast high-throughput screening program
Abstract Thousands of chemicals are directly added to or come in contact with food, many of which have undergone little to no toxicological evaluation. The landscape of the food-relevant chemical universe was evaluated using cheminformatics, and...
2016 / Agnes L. Karmaus, Dayne L. Filer, Matthew T. Martin, Keith A. Houck -
NLRX1 Acts as an Epithelial-Intrinsic Tumor Suppressor through the Modulation of TNF-Mediated Proliferation
Summary The mitochondrial Nod-like receptor protein NLRX1 protects against colorectal tumorigenesis through mechanisms that remain unclear. Using mice with an intestinal epithelial cells (IEC)-specific deletion of Nlrx1, we find that NLRX1 provides...
2016 / Ivan Tattoli, Samuel A. Killackey, Elisabeth G. Foerster, Raphael Molinaro, Charles Maisonneuve, et al. -
Developing nominal threshold levels for Phyllotreta cruciferae (Coleoptera: Chrysomelidae) damage on canola in Montana, USA
Abstract The flea beetles Phyllotreta cruciferae (Goeze) and Phyllotreta striolata (F.) (Coleoptera: Chrysomelidae) are serious pests infesting canola (Brassica napus L.; Brassicales: Brassicaceae) in the Northern Great Plains of the United States....
2014 / Khanobporn Tangtrakulwanich, Gadi V.P. Reddy, Shaohui Wu, John H. Miller, Victoria L. Ophus, et al. -
Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons
Abstract Objective Obesity is one of the primary healthcare challenges of the 21st century. Signals relaying information regarding energy needs are integrated within the brain to influence body weight. Central among these...
2016 / Luke K. Burke, Barbora Doslikova, Giuseppe D'Agostino, Megan Greenwald-Yarnell, Teodora Georgescu, et al. -
miR-378 Activates the Pyruvate-PEP Futile Cycle and Enhances Lipolysis to Ameliorate Obesity in Mice
Abstract Obesity has been linked to many health problems, such as diabetes. However, there is no drug that effectively treats obesity. Here, we reveal that miR-378 transgenic mice display reduced fat mass, enhanced lipolysis, and increased energy...
2016 / Yong Zhang, Changyin Li, Hu Li, Yipeng Song, Yixia Zhao, et al. -
Start-up phase of an anaerobic full-scale farm reactor – Appearance of mesophilic anaerobic conditions and establishment of the methanogenic microbial community
Abstract The goal of this study was to investigate how the microbial community structure establishes during the start-up phase of a full-scale farm anaerobic reactor inoculated with stale and cold cattle slurry. The 16S/18S high-throughput amplicon...
2016 / Xavier Goux, Magdalena Calusinska, Marie Fossépré, Emile Benizri, Philippe Delfosse -
IL-6 Inhibition With MEDI5117 Decreases The Fraction of Head and Neck Cancer Stem Cells and Prevents Tumor Recurrence
Abstract Head and neck squamous cell carcinomas (HNSCC) exhibit a small population of uniquely tumorigenic cancer stem cells (CSC) endowed with self-renewal and multipotency. We have recently shown that IL-6 enhances the survival and tumorigenic...
2016 / Kelsey A. Finkel, Kristy A. Warner, Samuel Kerk, Carol R. Bradford, Scott A. McLean, et al. -
Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems
Abstract Mitochondrial dysfunction has been widely associated with the pathology of Alzheimer's disease, but there is no consensus on whether it is a cause or consequence of disease, nor on the precise mechanism(s). We addressed these issues by...
2016 / Riyad El-Khoury, Eveliina Kaulio, Katariina A. Lassila, Damian C. Crowther, Howard T. Jacobs, et al. -
Maths on microbes: adding microbial ecophysiology to metagenomics2014 / Wilfred F. M. Röling
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Précis of Shared Agency: A Planning Theory of Acting Together2014 / Michael E. Bratman
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Modeling the survival kinetics of Salmonella in tree nuts for use in risk assessment
Abstract Salmonella has been shown to survive in tree nuts over long periods of time. This survival capacity and its variability are key elements for risk assessment of Salmonella in tree nuts. The aim of this study was to...
2016 / Sofia M. Santillana Farakos, Régis Pouillot, Nathan Anderson, Rhoma Johnson, Insook Son, et al. -
The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants
Abstract Farnesyl pyrophosphate synthase (FPPS) is the major molecular target of nitrogen-containing bisphosphonates (N-BPs), used clinically as bone resorption inhibitors. We investigated the role of threonine 201 (Thr201) and tyrosine 204 (Tyr204) ...
2015 / Maria K. Tsoumpra, Joao R. Muniz, Bobby L. Barnett, Aaron A. Kwaasi, Ewa S. Pilka, et al. -
microRNA 31 functions as an endometrial cancer oncogene by suppressing Hippo tumor suppressor pathway2014 / Takashi Mitamura, Hidemichi Watari, Lei Wang, Hiromi Kanno, Makiko Kitagawa, et al.
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Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells
Summary The intrinsic regenerative capacity of human fetal cardiac mesenchymal stromal cells (MSCs) has not been fully characterized. Here we demonstrate that we can expand cells with characteristics of cardiovascular progenitor cells from the MSC...
2016 / Agneta Månsson-Broberg, Sergey Rodin, Ivana Bulatovic, Cristián Ibarra, Marie Löfling, et al. -
Detection of siRNA-mediated target mRNA cleavage activities in human cells by a novel stem-loop array RT-PCR analysis
Abstract The small interfering RNA (siRNA)-mediated target mRNA cleavage activity generates cleaved mRNA fragments with varied termini, which creates major technical challenges for the accurate and efficient detection and verification of cleavage...
2016 / Jing Lin, Kai Xu, Jack A. Roth, Lin Ji -
Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population
Abstract Molecular surveillance provides a powerful approach to monitoring the resistance status of parasite populations in the field and for understanding resistance evolution. Oxamniquine was used to treat Brazilian schistosomiasis patients...
2016 / Frédéric D. Chevalier, Winka Le Clec’h, Nina Eng, Anastasia R. Rugel, Rafael Ramiro de Assis, et al. -
Chronic hepatitis B in pregnant women: is hepatitis B surface antigen quantification useful for viral load prediction?
Summary Background New cases of hepatitis B virus (HBV) infection continue to occur worldwide. Most of these are due to mother-to-child transmission (MTCT), with maternal viraemia as the most important contributing factor. The...
2015 / Masita Fujiko, Maisuri T. Chalid, Turyadi, Susan I. Ie, Maghfira, et al. -
Influenza A and methicillin-resistant Staphylococcus aureus co-infection in rhesus macaques – A model of severe pneumonia
Abstract Background Influenza results in up to 500,000 deaths annually. Seasonal influenza vaccines have an estimated 60% effectiveness, but provide little or no protection against novel subtypes, and may be less protective in...
2016 / Daniel S. Chertow, Jason Kindrachuk, Zong-Mei Sheng, Lindsey M. Pujanauski, Kurt Cooper, et al. -
Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis2016 / Anna C. Thomas, Zhiqiang Zeng, Jean-Baptiste Rivière, Ryan O’Shaughnessy, Lara Al-Olabi, et al.