Basic medicine topic list of research papers
-
Na + /Ca 2+ exchange and Na + /K + -ATPase in the heart2015 / Michael J. Shattock, Michela Ottolia, Donald M. Bers, Mordecai P. Blaustein, Andrii Boguslavskyi, et al.
-
Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling
Abstract Objective Exploitation of protective metabolic pathways within injured myocardium still remains an unclarified therapeutic target in heart disease. Moreover, while the roles of altered fatty acid and glucose metabolism in...
2014 / Rebecca C. Schugar, Ashley R. Moll, D. André d’Avignon, Carla J. Weinheimer, Attila Kovacs, et al. -
Galectin-3 Regulates Atrial Fibrillation Remodeling and Predicts Catheter Ablation Outcomes
Summary Atrial fibrillation (AF) usually starts as paroxysmal but can evolve relentlessly to the persistent and permanent forms. However, the mechanisms governing such a transition are unknown. The authors show that intracardiac serum levels of...
2016 / Yoshio Takemoto, Rafael J. Ramirez, Miki Yokokawa, Kuljeet Kaur, Daniela Ponce-Balbuena, et al. -
Nicorandil directly and cyclic GMP-dependently opens K+ channels in human bypass grafts
Abstract As we previously demonstrated the role of different K+ channels in the action of nicorandil on human saphenous vein (HSV) and human internal mammary artery (HIMA), this study aimed to analyse the contribution of the cGMP pathway in...
2015 / Marija Marinko, Aleksandra Novakovic, Dragoslav Nenezic, Ivan Stojanovic, Predrag Milojevic, et al. -
The hypotensive effect of acute and chronic AMP-activated protein kinase activation in normal and hyperlipidemic mice
Abstract AMP-activated protein kinase (AMPK) is present in the arterial wall and is activated in response to cellular stressors that raise AMP relative to ADP/ATP. Activation of AMPK in vivo lowers blood pressure but the influence of hyperlipidemia...
2015 / Fiona H. Greig, Marie-Ann Ewart, Eilidh McNaughton, Josephine Cooney, Corinne M. Spickett, et al. -
Endometrial infusion of human chorionic gonadotropin at the time of blastocyst embryo transfer does not impact clinical outcomes: a randomized, double-blind, placebo-controlled trial
Objective To determine whether endometrial hCG infusion at the time of human blastocyst transfer impacts implantation rates. Design Randomized double-blinded placebo-controlled...
2014 / Kathleen H. Hong, Eric J. Forman, Marie D. Werner, Kathleen M. Upham, Christina L. Gumeny, et al. -
CSF1 Restores Innate Immunity After Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure
Background & Aims Liver regeneration requires functional liver macrophages, which provide an immune barrier that is compromised after liver injury. The numbers of liver macrophages are controlled by macrophage colony-stimulating factor...
2015 / Benjamin M. Stutchfield, Daniel J. Antoine, Alison C. Mackinnon, Deborah J. Gow, Calum C. Bain, et al. -
Pathophysiological role of osteopontin and angiotensin II in atherosclerosis2016 / Yulong Ding, Jianing Chen, Guangying Cui, Yingfeng Wei, Chong Lu, et al.
-
The development and application of a high-sensitivity immunoassay for cardiac myosin–binding protein C
Cardiac troponins (cTns) are released and cleared slowly after myocardial injury. Cardiac myosin–binding protein C (cMyC) is a similar cardiac-restricted protein that has more rapid release and clearance kinetics. Direct comparisons are hampered by the lack of an...
2015 / Jack Marjot, Christoph Liebetrau, Robert J. Goodson, Thomas Kaier, Ekkehard Weber, et al. -
Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure
Abstract Background Omecamtiv mecarbil (OM) is a selective cardiac myosin activator that increases myocardial function in healthy volunteers and in patients with chronic heart failure. ...
2016 / John R. Teerlink, G. Michael Felker, John J.V. McMurray, Piotr Ponikowski, Marco Metra, et al. -
Cardiac specific titin N2B exon is a novel sensitive serological marker for cardiac injury2016 / Julius Bogomolovas, Alexander Gasch, Vilhelmas Bajoras, Dovilė Karčiauskaitė, Pranas Šerpytis, et al.
-
Lipid-lowering, hepatoprotective, and atheroprotective effects of the mixture Hong-Qu and gypenosides in hyperlipidemia with NAFLD rats
Abstract Background Hyperlipidemia and its complications are among the most harmful of diseases with a worldwide impact, which creates an urgent imperative to find safe and effective drugs for treatment. HG is mainly composed of...
2016 / San-Hu Gou, Hai-Feng Huang, Xin-Yue Chen, Jie Liu, Miao He, et al. -
Diallyl disulfide ameliorates isoproterenol induced cardiac hypertrophy activating mitochondrial biogenesis via eNOS-Nrf2-Tfam pathway in rats
Abstract The beneficial effect of garlic on cardiovascular disease is well known. However, the use of raw garlic against cardiac hypertrophy is not established. In the present study we explored whether raw garlic and its compound, diallyl disulfide...
2015 / Tarak Nath Khatua, Amit K. Dinda, Uday K. Putcha, Sanjay K. Banerjee -
Repeated high-intensity interval exercise shortens the positive effect on executive function during post-exercise recovery in healthy young males
Abstract A single bout of aerobic exercise improves executive function (EF), but only for a short period. Compared with a single bout of aerobic exercise, we recently found that high-intensity interval exercise (HIIE) could maintain a longer...
2016 / Hayato Tsukamoto, Tadashi Suga, Saki Takenaka, Daichi Tanaka, Tatsuya Takeuchi, et al. -
Manifestation of automaticity in the pulmonary-vein myocardium of rats with abdominal aorto-venocaval shunt
Abstract Effect of abdominal aorto-venocaval shunt (AVS) on the automaticity of the pulmonary-vein myocardium was studied in the rat. Spontaneous electrical activity was observed in one third of the isolated pulmonary-vein preparations from the AVS...
2015 / Shogo Hamaguchi, Yayoi Tsuneoka, Ayumi Tanaka, Masahiko Irie, Masato Tsuruta, et al. -
Ginsenoside Re inhibits pacemaker potentials via adenosine triphosphate-sensitive potassium channels and the cyclic guanosine monophosphate/nitric oxide-dependent pathway in cultured interstitial cells of Cajal from mouse small intestine
Abstract Background Ginseng belongs to the genus Panax. Its main active ingredients are the ginsenosides. Interstitial cells of Cajal (ICCs) are the pacemaker cells of the gastrointestinal (GI) tract. To understand the effects of...
2015 / Noo Ri Hong, Hyun Soo Park, Tae Seok Ahn, Hyun Jung Kim, Ki-Tae Ha, et al. -
Preparation of purified perikaryal and synaptosomal mitochondrial fractions from relatively small hypothalamic brain samples
Abstract In order to measure the activity of neuronal mitochondria, a representative proof of neuronal processes, physiologically relevant mitochondrial samples need to be gained as simply as possible. Existing methods are, however, either for...
2016 / David S. Kiss, Istvan Toth, Gergely Jocsak, Agnes Sterczer, Tibor Bartha, et al. -
Severe cardiomyopathy in a young patient with complete deficiency of adipose triglyceride lipase due to a novel mutation in PNPLA2 gene2016 / Maria Barbara Pasanisi, Sara Missaglia, Denise Cassandrini, Franco Salerno, Stefania Farina, et al.
-
Global Longitudinal Strain and Strain Rate in Type Two Diabetes Patients with Chronic Heart Failure: Relevance to Osteoprotegerin2016 / Peter Kruzliak, Alexander Berezin, Alexander Kremzer, Tatyana Samura, Roman Benacka, et al.
-
Synergistic effect of bioactive lipid and condition medium on cardiac differentiation of human mesenchymal stem cells from different tissues2016 / Lili Jiang, Yanwen Wang, Fang Pan, Xiubo Zhao, Henggui Zhang, et al.