Basic medicine topic list of research papers
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TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice
Abstract Objective Tissue inhibitor of metalloproteinase 3 (TIMP3) is an extracellular matrix (ECM) bound protein, which has been shown to be downregulated in human subjects and experimental models with cardiometabolic disorders,...
2015 / Robert Stöhr, Ben Arpad Kappel, Daniela Carnevale, Michele Cavalera, Maria Mavilio, et al. -
B-type natriuretic peptide expression and cardioprotection is regulated by Akt dependent signaling at early reperfusion
Abstract Exogenously administered B-type natriuretic peptide (BNP) has been shown to offer cardioprotection through activation of particulate guanylyl cyclase (pGC), protein kinase G (PKG) and KATP channel opening. The current study explores if...
2015 / L. Breivik, A. Jensen, S. Guvåg, E.K. Aarnes, A. Aspevik, et al. -
A potential linkage between mitochondrial function of the heart and leg muscles in patients with heart failure2015 / Takao Kato, Eisaku Nakane, Moritoshi Funasako, Shoichi Miyamoto, Toshiaki Izumi, et al.
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Docetaxel promotes the generation of anti-tumorigenic human macrophages
Abstract The taxanes Docetaxel and Paclitaxel are two of the standard chemotherapies for patients with metastatic breast cancer. The functional effect of Docetaxel and Paclitaxel on human innate immune cells of the myeloid lineage is not well...
2017 / Camilla Rydberg Millrud, Meliha Mehmeti, Karin Leandersson -
Effect of sample size re-estimation in adaptive clinical trials for Alzheimer's disease and mild cognitive impairment
Abstract Introduction The sample size re-estimation (SSR) adaptive design allows interim analyses and resultant modifications of the ongoing trial to preserve or increase power. We investigated the applicability of SSR in...
2015 / Guoqiao Wang, Richard E. Kennedy, Gary R. Cutter, Lon S. Schneider -
Oxidative Stress and Inflammation Differentially Elevated in Objective Versus Habitual Subjective Reduced Sleep Duration in Obstructive Sleep Apnea2016 / Theresanne DeMartino, Rawad El Ghoul, Lu Wang, James Bena, Stanley L. Hazen, et al.
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Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)2010 / A. J. Camm, P. Kirchhof, G. Y. H. Lip, U. Schotten, I. Savelieva, et al.
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An inexpensive device for monitoring patients' weights via automated hovering2014 / Jonathan A. Shaffer, Keith Diaz, Carmela Alcántara, Donald Edmondson, David J. Krupka, et al.
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Myeloperoxidase impairs the contractile function in isolated human cardiomyocytes
Abstract We set out to characterize the mechanical effects of myeloperoxidase (MPO) in isolated left-ventricular human cardiomyocytes. Oxidative myofilament protein modifications (sulfhydryl (SH)-group oxidation and carbonylation) induced by the...
2015 / Judit Kalász, Enikő T Pásztor, Miklós Fagyas, Ágnes Balogh, Attila Tóth, et al. -
Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: Role of fibrosis and connexin remodelling
Abstract Conduction abnormalities are frequently associated with cardiac disease, though the mechanisms underlying the commonly associated increases in PQ interval are not known. This study uses a chronic left ventricular (LV) apex myocardial...
2016 / Ashley M. Nisbet, Patrizia Camelliti, Nicola L. Walker, Francis L. Burton, Stuart M. Cobbe, et al. -
Prospective associations between sedentary time, sleep duration and adiposity in adolescents
Abstract Objective The objective of this study was to investigate whether objectively measured sedentary time and sleep duration are associated with changes in adiposity from mid- to late adolescence. ...
2015 / Paul J. Collings, Katrien Wijndaele, Kirsten Corder, Kate Westgate, Charlotte L. Ridgway, et al. -
Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity2016 / Yuanyuan Qian, Yali Zhang, Peng Zhong, Kesong Peng, Zheng Xu, et al.
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Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans
Abstract Background & aims Fibroblast growth factor 21 (FGF-21) is a liver-derived metabolic regulator induced by energy deprivation. However, its regulation in humans is incompletely understood. We addressed the origin and...
2015 / Jakob Schiøler Hansen, Jens Otto Clemmesen, Niels Henry Secher, Miriam Hoene, Andrea Drescher, et al. -
TRPM7is down-regulated in both left atria and left ventricle of ischaemic cardiomyopathy patients and highly related to changes in ventricular function2016 / Ana Ortega, Esther Roselló-Lletí, Estefanía Tarazón, Carolina Gil-Cayuela, Francisca Lago, et al.
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Sunday, 18 July 20102010 / M. Schuchardt, M. Toelle, T. Huang, A. Wiedon, M. Van Der Giet, et al.
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Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
Abstract Objective Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a...
2015 / Lalage A. Katunga, Preeti Gudimella, Jimmy T. Efird, Scott Abernathy, Taylor A. Mattox, et al. -
Impaired Na+-dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic atrial fibrillation
Abstract Shortened action-potential duration (APD) and blunted APD rate adaptation are hallmarks of chronic atrial fibrillation (cAF). Basal and muscarinic (M)-receptor-activated inward-rectifier K+ currents (IK1 and IK,ACh, respectively) contribute ...
2013 / Niels Voigt, Jordi Heijman, Anne Trausch, Elisa Mintert-Jancke, Lutz Pott, et al. -
ER stress mediates homocysteine-induced endothelial dysfunction: Modulation of IKCa and SKCa channels
Abstract Objective It remains incompletely understood how homocysteine impairs endothelial function. Whether mechanisms such as calcium-activated potassium (KCa) channels are involved is uncertain and the significance of...
2015 / Xiang-Chong Wang, Wen-Tao Sun, Cheuk-Man Yu, Shun-Hay Pun, Malcolm John Underwood, et al. -
Serotonin 2C receptor contributes to gender differences in stress-induced hypophagia in aged mice
Summary The combination of depression and anorexia may influence morbidity and progressive physical disability in the elderly. Gender differences exist in hypothalamic–pituitary–adrenal axis activation following stress exposure. The objective of...
2015 / Chihiro Yamada, Chiharu Sadakane, Miwa Nahata, Yayoi Saegusa, Koji Nakagawa, et al. -
Acute exposure to air pollution particulate matter aggravates experimental myocardial infarction in mice by potentiating cytokine secretion from lung macrophages2016 / Timoteo Marchini, Dennis Wolf, Nathaly Anto Michel, Maximilian Mauler, Bianca Dufner, et al.