Basic medicine topic list of research papers
-
Exercise and antioxidant supplements in the elderly
Abstract Both exercise and aging increase reactive oxygen species (ROS), which can result in damage to cells. Aging is the result of damage caused by ROS to the mitochondrial genome in post mitotic cells and numerous studies have demonstrated an...
2013 / Mari Carmen Gomez-Cabrera, Beatriz Ferrando, Thomas Brioche, Fabian Sanchis-Gomar, Jose Viña -
Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes
Abstract An increase of late Na+ current (INaL) in cardiac myocytes can raise the cytosolic Na+ concentration and is associated with activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and alterations of mitochondrial metabolism and...
2014 / Serge Viatchenko-Karpinski, Dmytro Kornyeyev, Nesrine El-Bizri, Grant Budas, Peidong Fan, et al. -
5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction
Abstract 5-Aminolevulinic acid (5-ALA) is a naturally occurring amino acid and precursor of heme and protoporphyrin IX (PpIX). Exogenously administrated 5-ALA increases the accumulation of PpIX in tumor cells specifically due to the compromised...
2015 / Masayuki Fujino, Yoshiaki Nishio, Hidenori Ito, Tohru Tanaka, Xiao-Kang Li -
Potent influence of obesity on suppression of plasma B-type natriuretic peptide levels in patients with acute heart failure: An approach using covariance structure analysis
Abstract Background Plasma B-type natriuretic peptide (BNP) levels may vary widely among patients with similar stages of heart failure, in whom obesity might be the only factor reducing plasma BNP levels. We investigated the effect ...
2016 / Koji Kinoshita, Makoto Kawai, Kosuke Minai, Kazuo Ogawa, Yasunori Inoue, et al. -
Insomnia in school-age children with Asperger syndrome or high-functioning autism2006 / Hiie Allik, Jan-Olov Larsson, Hans Smedje
-
Appetite regulation and weight control: the role of gut hormones2012 / B Perry, Y Wang
-
Dual blockade of endothelin action exacerbates up-regulated VEGF angiogenic signaling in the heart of lipopolysaccharide-induced endotoxemic rat model
Abstract Aims Sepsis is a cluster of heterogeneous syndromes associated with progressive endotoxemic developments, ultimately leading to damage of multiple organs, including the heart. However, the pathogenesis of sepsis-induced...
2014 / Masami Oki, Subrina Jesmin, Md. Majedul Islam, Chishimba Nathan Mowa, Tanzila Khatun, et al. -
Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy
Abstract Phosphorylated heat shock protein 20 (HSP20) is cardioprotective. Using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and a mouse model of pressure overload mediated hypertrophy, we show that peptide disruption of...
2014 / Tamara P. Martin, Maria P. Hortigon-Vinagre, Jane E. Findlay, Christina Elliott, Susan Currie, et al. -
The contribution of paraoxonase 1 and myeloperoxidase to HDL-cholesterol functionality2016 / Marzena Malara, Anna Kęska, Grażyna Lutosławska
-
Non-invasive Chamber-Specific Identification of Cardiomyocytes in Differentiating Pluripotent Stem Cells
Summary One major obstacle to the application of stem cell-derived cardiomyocytes (CMs) for disease modeling and clinical therapies is the inability to identify the developmental stage of these cells without the need for genetic manipulation or...
2016 / Eva Brauchle, Anne Knopf, Hannah Bauer, Nian Shen, Sandra Linder, et al. -
Cardiomyocyte generation from somatic sources — current status and future directions
Transdifferentiation of one cell type to another has garnered significant research efforts in recent years. As cardiomyocyte loss following myocardial infarction becomes debilitating for cardiac patients, the option of an autologous source of cardiomyocytes not...
2016 / Michael G Monaghan, Monika Holeiter, Shannon L Layland, Katja Schenke-Layland -
Celecoxib prevents pressure overload-induced cardiac hypertrophy and dysfunction by inhibiting inflammation, apoptosis and oxidative stress2015 / Chi Zhang, Fan Wang, Yingxia Zhang, Yimin Kang, Haisheng Wang, et al.
-
Cardio-protective effects of pentraxin 3 produced from bone marrow-derived cells against ischemia/reperfusion injury
Abstract Background Inflammation is one of major mechanisms contributing to the pathogenesis of myocardial ischemia/reperfusion (I/R) injury. Pentraxin 3 (PTX3), produced in response to inflammatory signals, acts as a humoral arm...
2015 / Takeshi Shimizu, Satoshi Suzuki, Akihiko Sato, Yuichi Nakamura, Kazuhiko Ikeda, et al. -
Effects of modulators of TASK potassium channels on rat pulmonary artery tone2008 / S. D. Shah
-
Practical applicability of landiolol, an ultra-short-acting β1-selective blocker, for rapid atrial and ventricular tachyarrhythmias with left ventricular dysfunction
Abstract Background Landiolol effectively controls rapid heart rate in atrial fibrillation or flutter (AF/AFL) patients with left ventricular (LV) dysfunction. However, predicting landiolol Responders and Non-Responders and...
2015 / Yuko Wada, Takeshi Aiba, Yasuyuki Tsujita, Hideki Itoh, Mitsuru Wada, et al. -
Reduction of heart rate by omega-3 fatty acids and the potential underlying mechanisms2012 / Jing X. Kang
-
Leap of Faith2014 / Rick Morgan
-
Biomaterial-Enhanced Cell and Drug Delivery: Lessons Learned in the Cardiac Field and Future Perspectives2016 / Hugh S. O'Neill, Laura B. Gallagher, Janice O'Sullivan, William Whyte, Clive Curley, et al.
-
Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists2016 / Leonid N Maslov, Igor Khaliulin, Peter R. Oeltgen, Natalia V. Naryzhnaya, Jian-Ming Pei, et al.
-
Pathophysiological Mechanisms of Tobacco-Related CVD
Cigarette smoking is a leading preventable risk factor for the development and progression of cardiovascular diseases (CVDs). Epidemiologic studies conclusively prove that both active smoking and secondhand smoke contribute significantly to morbidity and mortality ...
2012 / Salman Salahuddin, Dorairaj Prabhakaran, Ambuj Roy