Basic medicine topic list of research papers
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Blockade of Inflammation and Apoptosis Pathways by siRNA Prolongs Cold Preservation Time and Protects Donor Hearts in a Porcine Model2017 / Jia Wei, Shiyou Chen, Song Xue, Qiangru Zhu, Sha Liu, et al.
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Sesamin Protects Against Cardiac Remodeling Via Sirt3/ROS Pathway2017 / Di Fan, Zheng Yang, Fang-yuan Liu, Ya-Ge Jin, Ning Zhang, et al.
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Exercise intensity modulates capillary perfusion in correspondence with ACE I/D modulated serum angiotensin II levels
Abstract During exercise the renin–angiotensin system is stimulated. We hypothesized that the increase in serum angiotensin II (AngII) levels after exercise is dependent on exercise intensity and duration and secondly that people with the ACE-II...
2015 / Sander van Ginkel, Arnold de Haan, Jorn Woerdeman, Luc Vanhees, Erik Serné, et al. -
Sildenafil (Viagra®) Prevents Cox-1/ TXA2 Pathway-Mediated Vascular Hypercontractility in ApoE<sup>-/-</sup> Mice2017 / Marcos A.S. Leal, Ananda T. Dias, Marcella L. Porto, Bruna F. Brun, Agata L. Gava, et al.
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TPPU enhanced exercise-induced epoxyeicosatrienoic acid concentrations to exert cardioprotection in mice after myocardial infarction2017 / Yuan Guo, Fei Luo, Xv Zhang, Jingyuan Chen, Li Shen, et al.
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Regulator of G protein signalling 14 attenuates cardiac remodelling through the MEK–ERK1/2 signalling pathway2016 / Ying Li, Xiao-hong Tang, Xiao-hui Li, Hai-jiang Dai, Ru-jia Miao, et al.
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MicroRNA-155 and Anti-Müllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease2017 / Dag Eckersten, Christos Tsatsanis, Aleksander Giwercman, Laila Bruun, Mats Pihlsgård, et al.
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Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction
Abstract Mitogen-activated protein kinases (MAPKs) are involved in the regulation of cardiac hypertrophy and myocyte survival. Extracellular signal regulated protein kinase 1 and 2 (ERK1/2) are key components in the MAPK signaling pathways....
2014 / Susanne Ulm, Wei Liu, Min Zi, Hoyee Tsui, Sanjoy K. Chowdhury, et al. -
Endothelin-1 but not angiotensin II contributes to functional aging in murine carotid arteries
Abstract Aims Aging is a major risk factor for carotid artery disease and stroke. Endothelin-1 (ET-1) and angiotensin II (Ang II) are important modifiers of vascular disease, partly through increased activity of NADPH oxidase and...
2014 / Matthias R. Meyer, Natalie C. Fredette, Matthias Barton, Eric R. Prossnitz -
Monocyte subset distribution in patients with stable atherosclerosis and elevated levels of lipoprotein(a)
Background Lipoprotein(a) (Lp(a)) is a proatherogenic plasma lipoprotein currently established as an independent risk factor for the development of atherosclerotic disease and as a predictor for acute thrombotic complications. In addition, Lp(a)...
2015 / Konstantin A. Krychtiuk, Stefan P. Kastl, Sebastian L. Hofbauer, Anna Wonnerth, Georg Goliasch, et al. -
Mitochondrial calcium homeostasis as potential target for mitochondrial medicine
Abstract Mitochondria are crucial in different intracellular pathways of signal transduction. Mitochondria are capable of decoding a variety of extracellular stimuli into markedly different intracellular actions, ranging from energy production to...
2011 / Carlotta Giorgi, Chiara Agnoletto, Angela Bononi, Massimo Bonora, Elena De Marchi, et al. -
Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms
Abstract It is believed that the diabetic myocardium is refractory to cardioprotection by ischemic preconditioning (IPC) mainly because of impaired insulin signaling to phosphatidylinositol 3-kinase (PI3K) and protein kinase B (PKB or Akt). However, ...
2013 / Tanner M. Fullmer, Shaobo Pei, Yi Zhu, Crystal Sloan, Robert Manzanares, et al. -
Endogenous resident c-Kit cardiac stem cells increase in mice with an exercise-induced, physiologically hypertrophied heart
Abstract Physical activity evokes well-known adaptations in the cardiovascular system. Although exercise training induces cardiac remodeling, whether multipotent stem cells play a functional role in the hypertrophic process remains unknown. To...
2015 / Camila Ferreira Leite, Carolina Salomão Lopes, Angélica Cristina Alves, Caroline Santos Capitelli Fuzaro, Marcos Vinícius Silva, et al. -
Midkine exacerbates pressure overload-induced cardiac remodeling
Abstract Midkine is a multifunctional growth factor, and its serum levels are increased with the functional severity of heart failure. This study aimed to examine the role of midkine in heart failure pathogenesis. Midkine expression levels were...
2013 / Shunsuke Netsu, Tetsuro Shishido, Tatsuro Kitahara, Yuki Honda, Akira Funayama, et al. -
Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy
Abstract Abnormalities of cardiomyocyte Ca2+ homeostasis and excitation–contraction (E–C) coupling are early events in the pathogenesis of hypertrophic cardiomyopathy (HCM) and concomitant determinants of the diastolic dysfunction and arrhythmias...
2015 / C. Crocini, C. Ferrantini, M. Scardigli, R. Coppini, L. Mazzoni, et al. -
Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction
Abstract Background and objective Senescence marker protein 30 (SMP30) is assumed to behave as an anti-aging factor. Recently, we have demonstrated that deficiency of SMP30 exacerbates angiotensin II-induced cardiac hypertrophy,...
2013 / Tomofumi Misaka, Satoshi Suzuki, Makiko Miyata, Atsushi Kobayashi, Akihito Ishigami, et al. -
Ghrelin
Abstract Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the...
2015 / T.D. Müller, R. Nogueiras, M.L. Andermann, Z.B. Andrews, S.D. Anker, et al. -
Tetrahydrobiopterin reverse left ventricular hypertrophy and diastolic dysfunction through the PI3K/p-Akt pathway in spontaneously hypertensive rats
Abstract Hypertension induced hypertrophy and diastolic dysfunction and is associated with cardiac oxidation and reduced NO production. We hypothesized that tetrahydrobiopterin (BH4) can regulate the phosphatidylinositol 3-kinase/protein kinase B...
2015 / Peng Chang, Qiongying Wang, Han Xu, Mina Yang, Xin Lin, et al. -
Repetitive use of levosimendan for treatment of chronic advanced heart failure: Clinical evidence, practical considerations, and perspectives: An expert panel consensus
Abstract Background The intravenous inodilator levosimendan was developed for the treatment of patients with acutely decompensated heart failure. In the last decade scientific and clinical interest has arisen for its repetitive or...
2014 / M.S. Nieminen, J. Altenberger, T. Ben-Gal, A. Böhmer, J. Comin-Colet, et al. -
Flavonoids in prevention of diseases with respect to modulation of Ca-pump function2011 / Ľubica Horáková