Basic medicine topic list of research papers
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Autophagy: an adaptive physiological countermeasure to cellular senescence and ischaemia/reperfusion-associated cardiac arrhythmias2016 / Istvan Lekli, David Donald Haines, Gyorgy Balla, Arpad Tosaki
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BRD7 mediates hyperglycaemia-induced myocardial apoptosis via endoplasmic reticulum stress signalling pathway2016 / Xiao-meng Wang, Ying-cui Wang, Xiang-juan Liu, Qi Wang, Chun-mei Zhang, et al.
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Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction
Abstract Background Angiotensin-(1-9) [Ang-(1-9)] is a novel peptide of the counter-regulatory axis of the renin-angiotensin-aldosterone system previously demonstrated to have therapeutic potential in hypertensive cardiomyopathy...
2016 / Caroline Fattah, Katrin Nather, Charlotte S. McCarroll, Maria P. Hortigon-Vinagre, Victor Zamora, et al. -
Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation
Abstract Cardiomyopathies are a leading cause of heart failure and are often caused by mutations in sarcomeric genes, resulting in contractile dysfunction and cellular damage. This may stimulate the production of a robust proinflammatory response....
2016 / Thomas L. Lynch, Mohamed Ameen Ismahil, Anil G. Jegga, Michael J. Zilliox, Christian Troidl, et al. -
Challenges in assigning endocrine-specific modes of action: Recommendations for researchers and regulators2016 / Ellen M. Mihaich, Christoph Schäfers, David A. Dreier, Markus Hecker, Lisa Ortego, et al.
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Restoration of uridine 5′-triphosphate-suppressed delayed rectifying K+ currents by an NO activator KMUP-1 involves RhoA/Rho kinase signaling in pulmonary artery smooth muscle cells
Abstract We have demonstrated that KMUP-1 (7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine) blunts monocrotaline-induced pulmonary arterial hypertension by altering Ca2+ sensitivity, K+-channel function, endothelial nitric oxide...
2016 / Zen-Kong Dai, Chang-Ling Kao, Su-Ling Hsieh, Ing-Jun Chen, Bin-Nan Wu -
Myeloperoxidase Inhibition Improves Ventricular Function and Remodeling After Experimental Myocardial Infarction
Summary PF-1355 is an oral myeloperoxidase (MPO) inhibitor that successfully decreased elevated MPO activity in mouse myocardial infarction models. Short duration PF-1355 treatment for 7 days decreased the number of inflammatory cells and attenuated ...
2016 / Muhammad Ali, Benjamin Pulli, Gabriel Courties, Benoit Tricot, Matthew Sebas, et al. -
Pathophysiological Role of Adiponectin, Leptin and Asymmetric Dimethylarginine in the Process of Atherosclerosis2017 / Daniela Iv. Koleva, Maria M. Orbetzova, Julia G. Nikolova, Tanya I. Deneva
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Translation of Cardiac Myosin Activation With 2-Deoxy-ATP to Treat Heart Failure Via an Experimental Ribonucleotide Reductase-Based Gene Therapy
Summary Despite recent advances, chronic heart failure remains a significant and growing unmet medical need, reaching epidemic proportions carrying substantial morbidity, mortality, and costs. A safe and convenient therapeutic agent that produces...
2016 / Kassandra S. Thomson, Guy L. Odom, Charles E. Murry, Gregory G. Mahairas, Farid Moussavi-Harami, et al. -
Diversity of immune cell types in multiple sclerosis and its animal model: Pathological and therapeutic implications2017 / Yun Cheng, Li Sun, Zhongxiang Xie, Xueli Fan, Qingqing Cao, et al.
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Associations of common chronic non-communicable diseases and medical conditions with sleep-related problems in a population-based health examination study
Abstract A cross-sectional population-based survey, the National FINRISK 2012 Study, designed to monitor chronic diseases and their risk factors in Finland. A random sample of 10,000 adults aged 25–74 years, and of them, 64% (n=6424) participated...
2016 / Syaron Basnet, Ilona Merikanto, Tuuli Lahti, Satu Männistö, Tiina Laatikainen, et al. -
Novel method to assess intrinsic heart rate recovery in ambulatory ECG recordings tracks cardioprotective effects of chronic autonomic regulation therapy in patients enrolled in the ANTHEM-HF study2017 / Gerrard M. Carlson, Imad Libbus, Badri Amurthur, Bruce H. KenKnight, Richard L. Verrier
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ADMA, SDMA and L-Arginine may be Novel Targets in Pharmacotherapy for Complications due to Cardiopulmonary Bypass2016 / Aydın Kahraman, Emre Mutlu, Mustafa Aldağ
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Low circulating microRNA levels in heart failure patients are associated with atherosclerotic disease and cardiovascular-related rehospitalizations2017 / Eline L. Vegter, Ekaterina S. Ovchinnikova, Dirk J. van Veldhuisen, Tiny Jaarsma, Eugene Berezikov, et al.
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Effect of Staged Preconditioning on Biochemical Markers in the Patients Undergoing Coronary Artery Bypass Grafting2012 / Alireza Mohammadzadeh, Naser Jafari, Behzad Babapoursaatlou, Hossein Doustkami, Adallat Hosseinian, et al.
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Reactive oxygen species-targeted therapeutic interventions for atrial fibrillation2012 / Ali A. Sovari, Samuel C. Dudley
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Protein Kinase G-I Deficiency Induces Pulmonary Hypertension through Rho A/Rho Kinase Activation
Protein kinase G (PKG) plays an important role in the regulation of vascular smooth cell contractility and is a critical mediator of nitric oxide signaling, which regulates cardiovascular homeostasis. PKG-I–knockout (Prkg1 −/−) mice exhibit...
2012 / Yidan D. Zhao, Lei Cai, Muhammad K. Mirza, Xiaojia Huang, Dave L. Geenen, et al. -
Mining microarray datasets in nutrition: expression of the GPR120 (n-3 fatty acid receptor/sensor) gene is down-regulated in human adipocytes by macrophage secretions2012 / Paul Trayhurn, Gareth Denyer
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Alcohol Induced Mitochondrial Oxidative Stress and Alveolar Macrophage Dysfunction2014 / Yan Liang, Frank L. Harris, Lou Ann S. Brown
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The Role of Uric Acid in Kidney Fibrosis: Experimental Evidences for the Causal Relationship2014 / Il Young Kim, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak