Chemical sciences topic list of research papers
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Substrate specificity of mitochondrial intermediate peptidase analysed by a support-bound peptide library
Abstract The substrate specificity of recombinant human mitochondrial intermediate peptidase (hMIP) using a synthetic support-bound FRET peptide library is presented. The collected fluorescent beads, which contained the hydrolysed peptides generated ...
2015 / M.F.M. Marcondes, F.M. Alves, D.M. Assis, I.Y. Hirata, L. Juliano, et al. -
Modeling the mechanisms of biological GTP hydrolysis
Abstract Enzymes that hydrolyze GTP are currently in the spotlight, due to their molecular switch mechanism that controls many cellular processes. One of the best-known classes of these enzymes are small GTPases such as members of the Ras...
2015 / Alexandra T.P. Carvalho, Klaudia Szeler, Konstantinos Vavitsas, Johan Åqvist, Shina C.L. Kamerlin -
Mass spectrometry identification of age-associated proteins from the malaria mosquitoes Anopheles gambiae s.s. and Anopheles stephensi
Abstract This study investigated proteomic changes occurring in Anopheles gambiae and Anopheles stephensi during adult mosquito aging. These changes were evaluated using two-dimensional difference gel electrophoresis (2D-DIGE) and the identities of...
2015 / Maggy T. Sikulu, James Monkman, Keyur A. Dave, Marcus L. Hastie, Patricia E. Dale, et al. -
Lipid and protein maps defining arterial layers in atherosclerotic aorta
Abstract Subclinical atherosclerosis cannot be predicted and novel therapeutic targets are needed. The molecular anatomy of healthy and atherosclerotic tissue is pursued to identify ongoing molecular changes in atherosclerosis development. Mass...
2015 / Marta Martin-Lorenzo, Benjamin Balluff, Aroa S. Maroto, Ricardo J. Carreira, Rene J.M. van Zeijl, et al. -
Data from identification of diagnostic biomarkers and metabolic pathway shifts of heat-stressed lactating dairy cows
Abstract Controlling heat stress (HS) is a global challenge for the dairy industry. In this work, an integrated metabolomics and lipidomics approach using 1H nuclear magnetic resonance (NMR) and ultra-fast LC–MS in combination with multivariate...
2015 / He Tian, Weiyu Wang, Nan Zheng, Jianbo Cheng, Songli Li, et al. -
Concentration and risk of pharmaceuticals in freshwater systems are related to the population density and the livestock units in Iberian Rivers
Abstract Considerable amounts of pharmaceuticals are used in human and veterinary medicine, which are not efficiently removed during wastewater and slurries treatment and subsequently entering continuously into freshwater systems. The intrinsic...
2015 / Victoria Osorio, Aitor Larrañaga, Jaume Aceña, Sandra Pérez, Damià Barceló -
Determination of oligosaccharides and monosaccharides in Hakka rice wine by precolumn derivation high-performance liquid chromatography
Abstract This article presents a precolumn derivatization procedure with 1-phenyl-3-methyl-5-pyrazolone (PMP) reagent to detect oligosaccharides and monosaccharides in Hakka rice wine. The subsequent separation of the derivatized glucose–PMP also...
2015 / Weidong Bai, Xiaodi Fang, Wenhong Zhao, Shiqi Huang, Hongkang Zhang, et al. -
One-step synthesis of interpenetrating network hydrogels: Environment sensitivities and drug delivery properties
Abstract A novel interpenetrating network hydrogel for drug controlled release, composed of modified poly(aspartic acid) (KPAsp) and carboxymethyl chitosan (CMCTS), was prepared in aqueous system. The surface morphology and composition of hydrogels...
2015 / Jingqiong Lu, Yinhui Li, Deng Hu, Xiaoling Chen, Yongmei Liu, et al. -
Synthesis of an azido-tagged low affinity ratiometric calcium sensor
Abstract Changes in high localised concentrations of Ca2+ ions are fundamental to cell signalling. The synthesis of a dual excitation, ratiometric calcium ion sensor with a K d of 90 μM, is described. It is tagged with an azido...
2015 / Stuart T. Caldwell, Andrew G. Cairns, Marnie Olson, Susan Chalmers, Mairi Sandison, et al. -
Clam-inspired nanoparticle immobilization method using adhesive tape as microchip substrate
Abstract Immobilization of the suspended nanoparticles is essential for many microfluidic applications. This work reports a novel biomimetic method to immobilize nanoparticles by using a common adhesive tape as the substrate of microfluidic chip. It ...
2015 / Xiaowen Huang, Yujiao Zhu, Xuming Zhang, Zhiyong Bao, Dang Yuan Lei, et al. -
Prediction of anticancer peptides against MCF-7 breast cancer cells from the peptidomes of Achatina fulica mucus fractions
Abstract Several reports have shown antimicrobial and anticancer activities of mucous glycoproteins extracted from the giant African snail Achatina fulica. Anticancer properties of the snail mucous peptides remain incompletely revealed. The aim of...
2015 / Teerasak E-kobon, Pennapa Thongararm, Sittiruk Roytrakul, Ladda Meesuk, Pramote Chumnanpuen -
Bioprospecting optimal phenology for bioactive molecules in native golden yellow Pleurotus citrinopileatus Singer
Abstract Objective To bioprospect optimal phenological phases as source of novel molecules from native golden yellow Pleurotus citrinopileatus across four phenologies in both aqueous and ethanol extracts, and identify novel...
2015 / Godfrey Nattoh, Erastus Gatebe, Fredrick Musieba, Julius Mathara -
An interlaboratory comparison of nanosilver characterisation and hazard identification: Harmonising techniques for high quality data
Abstract Within the FP7 EU project NanoValid a consortium of six partners jointly investigated the hazard of silver nanoparticles (AgNPs) paying special attention to methodical aspects that are important for providing high-quality ecotoxicity data....
2015 / Anita Jemec, Anne Kahru, Annegret Potthoff, Damjana Drobne, Margit Heinlaan, et al. -
8-Substituted Pyrido[3,4- d ]pyrimidin-4(3 H )-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors2016 / Vassilios Bavetsias, Rachel M. Lanigan, Gian Filippo Ruda, Butrus Atrash, Mark G. McLaughlin, et al.
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Isomer effects in fragmentation of Polycyclic Aromatic Hydrocarbons
Abstract We have observed significant differences in the fragmentation patterns of isomeric Polycyclic Aromatic Hydrocarbon (PAH) cations following collisions with helium atoms at center-of-mass energies around 100eV. This is in contrast to the...
2015 / M.H. Stockett, M. Gatchell, N. de Ruette, L. Giacomozzi, T. Chen, et al. -
Anti-prion activity found in beetle grub hemolymph of Trypoxylus dichotomus septentrionalis
Abstract No remedies for prion disease have been established, and the conversion of normal to abnormal prion protein, a key event in prion disease, is still unclear. Here we found that substances in beetle grub hemolymph, after they were browned by...
2015 / Taichi Hamanaka, Keiko Nishizawa, Yuji Sakasegawa, Hiroshi Kurahashi, Ayumi Oguma, et al. -
Development of a C3c-based ELISA method for the determination of anti-complementary potency of Bupleurum polysaccharides
Abstract Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of complement inhibitors against...
2015 / Mulu Wu, Hong Li, Yunyi Zhang, Daofeng Chen -
Mapping the spatial distribution and activity of 226Ra at legacy sites through Machine Learning interpretation of gamma-ray spectrometry data
Abstract Radium (226Ra) contamination derived from military, industrial, and pharmaceutical products can be found at a number of historical sites across the world posing a risk to human health. The analysis of spectral data derived using gamma-ray...
2016 / Adam Varley, Andrew Tyler, Leslie Smith, Paul Dale, Mike Davies -
A Radium-223 microgenerator from cyclotron-produced trace Actinium-227
Abstract The alpha particle emitter Radium-223 dichloride (223RaCl2) has recently been approved for treatment of late-stage bone metastatic prostate cancer. There is considerable interest in studying this new agent outside of the clinical setting,...
2016 / Diane S. Abou, Juile Pickett, John E. Mattson, Daniel L.J. Thorek -
Chemical constituents from Sidastrum paniculatum and evaluation of their leishmanicidal activity2015 / Yanna C.F. Teles, Otemberg S. Chaves, Maria de Fátima Agra, Leônia Maria Batista, Aline C. de Queiroz, et al.