Biological sciences topic list of research papers
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Deregulated Expression of the Human Tumor Marker CEA and CEA Family Member CEACAM6 Disrupts Tissue Architecture and Blocks Colonocyte Differentiation
Abstract Human carcinoembryonic antigen (CEA) and the CEA family member CEACAM6 (formerly nonspecific crossreacting antigen [NCA]) function in vitro, at least, as homotypic intercellular adhesion molecules and, in model systems, can block the...
2002 / Christian Ilantzis, Luisa Demarte, Robert A. Screaton, Clifford P. Stanners -
Identification and characterization of a new allele for ZEBRA LEAF 2, a gene encoding carotenoid isomerase in rice
Abstract The Japonica rice cultivar ‘Nipponbare’ was mutagenized by ethyl methane sulfonate (EMS) to obtain a stable and heritable “zebra leaf” mutant zb2. Under natural conditions, yellow and green striped leaves appeared at the seedling stage of...
2014 / J. Zhao, Y. Fang, S. Kang, B. Ruan, J. Xu, et al. -
Cytotoxic Cyplasin of the Sea Hare, Aplysia punctata, cDNA Cloning, and Expression of Bioactive Recombinants in Insect Cells
Abstract A 56-kDa protein isolated from the mucus of the European sea hare Aplysia punctata shows a preferential toxicity to autonomously growing transformed mammalian cells. Cell death induced by this protein differs from both apoptosis and...
2002 / Christian Petzelt, Gaby Joswig, Hermann Stammer, Dieter Werner -
Acetylcholine receptor subunit and P-glycoprotein transcription patterns in levamisole-susceptible and -resistant Haemonchus contortus
Abstract The mechanism of resistance to the anthelmintic levamisole in parasitic nematodes is poorly understood, although there is some evidence implicating changes in expression of nicotinic acetylcholine receptor (nAChR) subunit genes. Hence, in...
2013 / Ranbir S. Sarai, Steven R. Kopp, Glen T. Coleman, Andrew C. Kotze -
Tapetal and parenchymatic anther tissues participate in polyad adhesive production in Calliandra brevipes (Leguminosae)
Abstract Calliandra brevipes Benth. is an American shrubby species largely used for ornamental purposes. Like all other Calliandra species it has heteromorphic pollen grains shed in ellipse-shaped, calymmate polyads and a...
2013 / Liana Carneiro Capucho, Simone Pádua Teixeira -
The Salmonella Kinase SteC Targets the MAP Kinase MEK to Regulate the Host Actin Cytoskeleton
Summary After host cell entry, Salmonella replicate in membrane-bound compartments, which accumulate a dense meshwork of F-actin through the kinase activity of the Salmonella SPI-2 type III secretion effector SteC. We find that SteC promotes actin...
2012 / Charlotte Odendall, Nathalie Rolhion, Andreas Förster, John Poh, Douglas J. Lamont, et al. -
Persistent efficacy and production benefits following use of extended-release injectable eprinomectin in grazing beef cattle under field conditions
Abstract Seven studies were conducted in commercial grazing operations to confirm anthelmintic efficacy, assess acceptability, and measure the productivity response of cattle to treatment with eprinomectin in an extended-release injectable...
2012 / B.N. Kunkle, J.C. Williams, E.G. Johnson, B.E. Stromberg, T.A. Yazwinski, et al. -
Hypomorphic mutations of SEC23B gene account for mild phenotypes of congenital dyserythropoietic anemia type II
Abstract Congenital dyserythropoietic anemia type II, a recessive disorder of erythroid differentiation, is due to mutations in SEC23B, a component of the core trafficking machinery COPII. In no case homozygosity or compound heterozygosity for...
2013 / Roberta Russo, Concetta Langella, Maria Rosaria Esposito, Antonella Gambale, Francesco Vitiello, et al. -
Reversible contraction of isolated mammalian cochlear hair cells
Abstract Outer hair cells were isolated from the guinea pig cochlea using a micromechanical non-enzymatic procedure. Depolarization of outer hair cells in the presence of 25–125 mM K+ was accompanied by a longitudinal contraction of the isolated...
2003 / H.P. Zenner, U. Zimmermann, U. Schmitt -
Molecular Modeling and Molecular Dynamics Simulations of Recombinase Rad51
Abstract The Rad51 ATPase plays central roles in DNA homologous recombination. Yeast Rad51 dimer structure in the active form of the filament was constructed using homology modeling techniques, and all-atom molecular dynamics (MD) simulations were...
2013 / Yuichi Kokabu, Mitsunori Ikeguchi -
The hormonal signature of energy deficit: Increasing the value of food reward
Abstract Energy deficit is characterised by high ghrelin levels, and low leptin and insulin levels and we suggest that this provides a metabolic signature sensed by the brain to increase motivated behaviour to obtain food. We believe that the...
2013 / Sarah H. Lockie, Zane B. Andrews -
New approaches to studying Plasmodium falciparum merozoite invasion and insights into invasion biology
Abstract Merozoite invasion of human red blood cells by Plasmodium falciparum is essential for blood stage asexual replication and the development of malaria disease. Despite this, many of the processes involved in invasion are poorly understood....
2012 / Michelle J. Boyle, Danny W. Wilson, James G. Beeson -
Zinc finger function of HIV-1 nucleocapsid protein is required for removal of 5′-terminal genomic RNA fragments: A paradigm for RNA removal reactions in HIV-1 reverse transcription
Abstract During (−) strong-stop DNA [(−) SSDNA] synthesis, RNase H cleavage of genomic viral RNA generates small 5′-terminal RNA fragments (14–18 nt) that remain annealed to the DNA. Unless these fragments are removed, the minus-strand transfer...
2012 / Christopher B. Hergott, Mithun Mitra, Jianhui Guo, Tiyun Wu, Jennifer T. Miller, et al. -
In Vivo Direct Molecular Imaging of Early Tumorigenesis and Malignant Progression Induced by Transgenic Expression of GFP-Met
Abstract The tyrosine kinase receptor Met and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), play an important role in normal developmental processes, as well as in tumorigenicity and metastasis. We constructed a green fluorescent...
2006 / Sharon Moshitch-Moshkovitz, Galia Tsarfaty, Dafna W. Kaufman, Gideon Y. Stein, Keren Shichrur, et al. -
Persistent STAT3 Activation in Colon Cancer Is Associated with Enhanced Cell Proliferation and Tumor Growth
Abstract Colorectal carcinoma (CRC) is a major cause of morbidity and mortality in Western countries. It has so far been molecularly defined mainly by alterations of the Wnt pathway. We show here for the first time that aberrant activities of the...
2005 / Florian M. Corvinus, Carina Orth, Richard Moriggl, Svetlana A. Tsareva, Stefan Wagner, et al. -
Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression
Summary We analyzed aging parameters using a mechanistic target of rapamycin (mTOR) hypomorphic mouse model. Mice with two hypomorphic (mTORΔ/Δ) alleles are viable but express mTOR at approximately 25% of wild-type levels. These animals demonstrate...
2013 / J. Julie Wu, Jie Liu, Edmund B. Chen, Jennifer J. Wang, Liu Cao, et al. -
Limitations of MIC as the sole criterion in antimicrobial drug dosage regimen design: The need for full characterization of antimicrobial pharmacodynamic profile especially for drug-resistant organisms2013 / Ronette Gehring, Jim E. Riviere
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Phoenix 2: A locally installable large-scale 16S rRNA gene sequence analysis pipeline with Web interface
Abstract We have developed Phoenix 2, a ribosomal RNA gene sequence analysis pipeline, which can be used to process large-scale datasets consisting of more than one hundred environmental samples and containing more than one million reads...
2013 / Jung Soh, Xiaoli Dong, Sean M. Caffrey, Gerrit Voordouw, Christoph W. Sensen -
The MDM-2 Antagonist Nutlin-3 Promotes the Maturation of Acute Myeloid Leukemic Blasts
Abstract The small-molecule inhibitor of murine double minute (MDM-2), Nutlin-3, induced variable apoptosis in primary acute myeloid leukemia (AML) blasts, promoted myeloid maturation of surviving cells, as demonstrated by analysis of CD11 b, CD14...
2007 / Paola Secchiero, Carlotta Zerbinati, Elisabetta Melloni, Daniela Milani, Diana Campioni, et al. -
Glutathione in Cerebral Microvascular Endothelial Biology and Pathobiology: Implications for Brain Homeostasis2012 / Wei Li, Carmina Busu, Magdalena L. Circu, Tak Yee Aw