Biological sciences topic list of research papers
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Kinesin-14: the roots of reversal2010 / Robert A Cross
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A novel deconvolution method for modeling UDP-N-acetyl-D-glucosamine biosynthetic pathways based on 13C mass isotopologue profiles under non-steady-state conditions2011 / Hunter NB Moseley, Andrew N Lane, Alex C Belshoff, Richard M Higashi, Teresa WM Fan
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Golgi localisation of GMAP210 requires two distinct cis-membrane binding mechanisms2009 / Jesus Cardenas, Sabrina Rivero, Bruno Goud, Michel Bornens, Rosa M Rios
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Tracing lineages to uncover neuronal identity2011 / Lia Panman, Thomas Perlmann
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Tintinnids (Protozoa: Ciliata) from the coast of Hurghada Red Sea, Egypt
Abstract An examination of plankton samples collected from the inshore and offshore waters in the vacancy of Hurghada area in the Egyptian Red Sea coast revealed the presence of a diverse community of planktonic tintinnids (Protozoa). Ninety two...
2013 / Mohamed M. Abou Zaid, Ahmed M. Hellal -
Massively parallel tag sequencing reveals the complexity of anaerobic marine protistan communities2009 / Thorsten Stoeck, Anke Behnke, Richard Christen, Linda Amaral-Zettler, Maria J Rodriguez-Mora, et al.
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Long-Timescale Dynamics and Regulation of Sec-Facilitated Protein Translocation
Summary We present a coarse-grained modeling approach that spans the nanosecond- to minute-timescale dynamics of cotranslational protein translocation. The method enables direct simulation of both integral membrane protein topogenesis and...
2012 / Bin Zhang, Thomas F. Miller -
E3 Ubiquitin Ligases as Cancer Targets and Biomarkers
Abstract E3 ubiquitin ligases are a large family of proteins that are engaged in the regulation of the turnover and activity of many target proteins. Together with ubiquitinactivating enzyme El and ubiquitin-conjugating enzyme E2, E3 ubiquitin...
2006 / Yi Sun -
Molecular Basis for Specific Regulation of Neuronal Kinesin-3 Motors by Doublecortin Family Proteins
Summary Doublecortin (Dcx) defines a growing family of microtubule (MT)-associated proteins (MAPs) involved in neuronal migration and process outgrowth. We show that Dcx is essential for the function of Kif1a, a kinesin-3 motor protein that traffics ...
2012 / Judy S. Liu, Christian R. Schubert, Xiaoqin Fu, Franck J. Fourniol, Jyoti K. Jaiswal, et al. -
Effect of acoustic similarity on short-term auditory memory in the monkey
Abstract Recent evidence suggests that the monkey’s short-term memory in audition depends on a passively retained sensory trace as opposed to a trace reactivated from long-term memory for use in working memory. Reliance on a passive sensory trace...
2013 / Brian H. Scott, Mortimer Mishkin, Pingbo Yin -
Shear Stress Inhibits Apoptosis of Ischemic Brain Microvascular Endothelial Cells2013 / Shan Tian, Yulong Bai, Lin Yang, Xinggang Wang, Yi Wu, et al.
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A golden approach to ion channel inhibition
Drugs are often used in combination and, for pharmacologists, the manner of their interactions can cast light on drug mechanisms and biological processes. Here we provide simplified descriptions of commonly used analytical methods for analysing drug combinations...
2013 / Gavin E. Jarvis, Andrew J. Thompson -
The Anticancer Drug Tamoxifen Counteracts the Pathology in a Mouse Model of Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is a severe disorder characterized by progressive muscle wasting, respiratory and cardiac impairments, and premature death. No treatment exists so far, and the identification of active substances to fight DMD is urgently needed....
2013 / Olivier M. Dorchies, Julie Reutenauer-Patte, Elyes Dahmane, Hesham M. Ismail, Olivier Petermann, et al. -
Residential mobility, socioeconomic context and body mass index in a cohort of urban South African adolescents
Abstract Adolescents who are changing residence, as well as their social and economic circumstances may experience lifestyle changes that have an effect on body composition outcomes such as undernutrition, overweight or obesity. This paper uses data ...
2012 / Carren Ginsburg, Paula L. Griffiths, Linda M. Richter, Shane A. Norris -
Ribonucleotide reductase is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells with dual resistant factors
Abstract Gemcitabine is widely used for pancreatic, lung, and bladder cancer. However, drug resistance against gemcitabine is a large obstacle to effective chemotherapy. Nucleoside transporters, nucleoside and nucleotide metabolic enzymes, and...
2015 / Kentaro Minami, Yoshinari Shinsato, Masatatsu Yamamoto, Homare Takahashi, Shaoxuan Zhang, et al. -
Regulation of the Pathological Vasculature of Malignant Astrocytomas by Angiopoietin-1
Abstract Malignant astrocytomas are the most common and highly vascularized of all primary adult brain tumors. The histopathological hallmarks of malignant astrocytomas are microvascular proliferation and formation of vascular entities, which are...
2006 / Gelareh Zadeh, Rob Reti, Keyvan Koushan, Qian Baoping, Patrick Shannon, et al. -
MicroRNA regulation of endothelial homeostasis and commitment—implications for vascular regeneration strategies using stem cell therapies
Abstract Human embryonic (hESC) and induced pluripotent (hiPSC) stem cells have broad therapeutic potential in the treatment of a range of diseases, including those of the vascular system. Both hESCs and hiPSCs have the capacity for indefinite...
2013 / Elizabeth Scott, Komal Loya, Joanne Mountford, Graeme Milligan, Andrew H. Baker -
Fkh1 and Fkh2 associate with Sir2 to control CLB2 transcription under normal and oxidative stress conditions2013 / Christian Linke, Edda Klipp, Hans Lehrach, Matteo Barberis, Sylvia Krobitsch
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Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
Summary The gene encoding the Krebs cycle enzyme fumarate hydratase (FH) is mutated in hereditary leiomyomatosis and renal cell cancer (HLRCC). Loss of FH activity causes accumulation of intracellular fumarate, which can directly modify cysteine...
2013 / Nicola Ternette, Ming Yang, Mahima Laroyia, Mitsuhiro Kitagawa, Linda O’Flaherty, et al. -
Merkel cell polyomavirus infection occurs during early childhood and is transmitted between siblings
Abstract Merkel cell polyomavirus (MCPyV) is thought to be the etiological agent of Merkel cell carcinoma, but little is known about its distribution and modes of transmission. We conducted seroepidemiological surveys in more than 1000 individuals,...
2013 / Claire Martel-Jantin, Vincent Pedergnana, Jérôme T.J. Nicol, Valérie Leblond, David-Alexandre Trégouët, et al.