Biological sciences topic list of research papers
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Comparative proteomic analysis reveals molecular mechanism of seedling roots of different salt tolerant soybean genotypes in responses to salinity stress
Abstract Salinity stress is one of the major abiotic stresses that limit agricultural yield. To understand salt-responsive protein networks in soybean seedling, the extracted proteins from seedling roots of two different genotypes (Lee 68 and...
2014 / Hongyu Ma, Liru Song, Zhigang Huang, Yan Yang, Shuang Wang, et al. -
Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries
Summary Inhibition of cholesterol export from late endosomes causes cellular cholesterol imbalance, including cholesterol depletion in the trans-Golgi network (TGN). Here, using Chinese hamster ovary (CHO) Niemann-Pick type C1 (NPC1) mutant cell...
2014 / Meritxell Reverter, Carles Rentero, Ana Garcia-Melero, Monira Hoque, Sandra Vilà de Muga, et al. -
PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity in Latvians, Lithuanians and Taiwanese
Abstract PSMA6 (rs2277460, rs1048990), PSMC6 (rs2295826, rs2295827) and PSMA3 (rs2348071) genetic diversity was investigated in 1438 unrelated subjects from Latvia, Lithuania and Taiwan. In general, polymorphism of each...
2014 / Tatjana Sjakste, Natalia Paramonova, Lawrence Shi-Shin Wu, Zivile Zemeckiene, Brigita Sitkauskiene, et al. -
Establishment of the integrated applied core collection and its comparison with mini core collection in soybean (Glycine max)
Abstract The concept of core collection (CC) provides a new way of management and utilization of plant germplasm resources. In this study, an integrated applied core collection (IACC) of soybean was developed based on evaluation data for desirable...
2013 / Yong Guo, Yinghui Li, Huilong Hong, Li-Juan Qiu -
ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal
Abstract Nanog regulates human and mouse embryonic stem (ES) cell self-renewal activity. Activation of ERKs signaling negatively regulates ES cell self-renewal and induces differentiation, but the mechanisms are not understood. We found that ERK1...
2014 / Sung-Hyun Kim, Myoung Ok Kim, Yong-Yeon Cho, Ke Yao, Dong Joon Kim, et al. -
Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization
Summary Hepatocellular carcinoma (HCC) is a deadly form of liver cancer that is increasingly prevalent. We analyzed global gene expression profiling of 361 HCC tumors and 49 adjacent noncancerous liver samples by means of combinatorial network-based ...
2015 / Elias Björnson, Bani Mukhopadhyay, Anna Asplund, Nusa Pristovsek, Resat Cinar, et al. -
miR-500a-5p regulates oxidative stress response genes in breast cancer and predicts cancer survival2017 / Davide Degli Esposti, Vasily N. Aushev, Eunjee Lee, Marie-Pierre Cros, Jun Zhu, et al.
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Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma2017 / Raffaele Simeoli, Karli Montague, Hefin R. Jones, Laura Castaldi, David Chambers, et al.
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Characterization of the early molecular changes in the glomeruli of Cd151 −/− mice highlights induction of mindin and MMP-102017 / Crystal Naudin, Brian Smith, Danielle R. Bond, Matthew D. Dun, Rodney J. Scott, et al.
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Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes2017 / Ruda de Luna Almeida Santos, Lin Bai, Pradeep K. Singh, Naoka Murakami, Hao Fan, et al.
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Disturbance and diversity in a continental archipelago: a mechanistic framework linking area, height, and exposure2017 / Christopher J. Neufeld, Samuel Starko, Kevin C. Burns
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Near-simultaneous intravital microscopy of glucose uptake and mitochondrial membrane potential, key endpoints that reflect major metabolic axes in cancer2017 / Caigang Zhu, Amy F. Martinez, Hannah L. Martin, Martin Li, Brian T. Crouch, et al.
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Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice2017 / Martín Alcalá, María Calderon-Dominguez, Eduviges Bustos, Pilar Ramos, Núria Casals, et al.
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The flavonoid apigenin inhibits hepatitis C virus replication by decreasing mature microRNA122 levels
Abstract Despite recent progress in the development of direct-acting antivirals against hepatitis C virus (HCV), chronic HCV infection remains an important health burden worldwide. MicroRNA122 (miR122), a liver-specific microRNA (miRNA), positively...
2014 / Chikako Shibata, Motoko Ohno, Motoyuki Otsuka, Takahiro Kishikawa, Kaku Goto, et al. -
Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress
Abstract Alcoholic liver disease (ALD) is a major cause of chronic liver disease and a growing health concern in theworld. While the pathogenesis of ALD is poorly characterized key players identified in experimental models and patients, such as...
2014 / Montserrat Marí, Albert Morales, Anna Colell, Carmen García-Ruiz, Jose C. Fernández-Checa -
The phosphorylation of Hsp20 enhances its association with amyloid-β to increase protection against neuronal cell death
Abstract Up-regulation of Hsp20 protein levels in response to amyloid fibril formation is considered a key protective response against the onset of Alzheimer's disease (AD). Indeed, the physical interaction between Hsp20 and Aβ is known to prevent...
2014 / Ryan T. Cameron, Steven D. Quinn, Lynn S. Cairns, Ruth MacLeod, Ifor D.W. Samuel, et al. -
Evaluation of mutagenic and antimicrobial properties of brown propolis essential oil from the Brazilian Cerrado biome
Abstract Biological, and particularly antimicrobial, activities have been demonstrated for the essential oil of propolis samples worlwide, yet their mutagenic effects remain unknown. To correlate antimicrobial effects with mutagenic risks, the...
2015 / Fábio H. Fernandes, Zaira da R. Guterres, Ivana M.P. Violante, Tiago F.S. Lopes, Walmir S. Garcez, et al. -
Phosphorylation of RSK2 at Tyr529 by FGFR2-p38 enhances human mammary epithelial cells migration
Abstract The members of p90 ribosomal S6 kinase (RSK) family of Ser/Thr kinases are downstream effectors of MAPK/ERK pathway that regulate diverse cellular processes including cell growth, proliferation and survival. In carcinogenesis, RSKs are...
2014 / Dominika Czaplinska, Lukasz Turczyk, Alicja Grudowska, Magdalena Mieszkowska, Andrea D. Lipinska, et al. -
Structure of fumarate hydratase from Rickettsia prowazekii , the agent of typhus and suspected relative of the mitochondria2011 / Isabelle Phan, Sandhya Subramanian, Christian Olsen, Thomas E. Edwards, Wenjin Guo, et al.
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Comparative genomics of oral isolates of Streptococcus mutans by in silico genome subtraction does not reveal accessory DNA associated with severe early childhood caries
Abstract Comparative genomics is a popular method for the identification of microbial virulence determinants, especially since the sequencing of a large number of whole bacterial genomes from pathogenic and non-pathogenic strains has become...
2013 / Silvia Argimón, Kranti Konganti, Hao Chen, Alexander V. Alekseyenko, Stuart Brown, et al.