Biological sciences topic list of research papers
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Complete genome sequence of the aerobically denitrifying thermophilic bacterium Chelatococcus daeguensis TAD12017 / Yunlong Yang, Ershu Lin, Shaobin Huang
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Virgin olive oil ameliorates deltamethrin-induced nephrotoxicity in mice: A biochemical and immunohistochemical assessment
Abstract Objective A major class of synthetic pyrethroid insecticide, deltamethrin (DM), can elicit pathophysiological effects through oxidative stress in non-targeted organisms such as mammals. There is accumulating evidence that...
2016 / Ali Reza khalatbary, Hassan Ahmadvand, Davood Nasiry Zarrin Ghabaee, Abbasali Karimpour Malekshah, Azam Navazesh -
A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1
Summary Transcription factors (TFs) play multiple roles in development. Given this multifunctionality, it has been assumed that TFs are evolutionarily highly constrained. Here, we investigate the molecular mechanisms for the origin of a derived...
2016 / Mauris C. Nnamani, Soumya Ganguly, Eric M. Erkenbrack, Vincent J. Lynch, Laura S. Mizoue, et al. -
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration2016 / Marcel Smid, F. Germán Rodríguez-González, Anieta M. Sieuwerts, Roberto Salgado, Wendy J. C. Prager-Van der Smissen, et al.
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Msx1 and Msx2 function together in the regulation of primordial germ cell migration in the mouse
Abstract Primordial germ cells (PGCs) are a highly migratory cell population that gives rise to eggs and sperm. Much is known about PGC specification, but less about the processes that control PGC migration. In this study, we document a deficiency...
2016 / Jingjing Sun, Man-Chun Ting, Mamoru Ishii, Robert Maxson -
Cloning, recombinant production and crystallographic structure of Proliferating Cell Nuclear Antigen from radioresistant archaeon Thermococcus gammatolerans
Abstract Thermococcus gammatolerans is a strictly anaerobic; hyperthermophilicarchaeon belongs to the order Thermococcales in the phylum Euryarchaeota. It was extracted from a hydrothermal vent from the Guaymas Basin (Gulf of...
2016 / A.A. Venancio-Landeros, E. Rudiño-Piñera, C.S. Cardona-Félix -
Cbx8 Acts Non-canonically with Wdr5 to Promote Mammary Tumorigenesis
Summary Chromatin-mediated processes influence the development and progression of breast cancer. Using murine mammary carcinoma-derived tumorspheres as a functional readout for an aggressive breast cancer phenotype, we performed a loss-of-function...
2016 / Chi-Yeh Chung, Zhen Sun, Gavriel Mullokandov, Almudena Bosch, Zulekha A. Qadeer, et al. -
Interspecific variation in the relationship between clutch size, laying date and intensity of urbanization in four species of hole-nesting birds2016 / Marie Vaugoyeau, Frank Adriaensen, Alexandr Artemyev, Jerzy Bańbura, Emilio Barba, et al.
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Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly
Summary The regulation of mitochondrial RNA processing and its importance for ribosome biogenesis and energy metabolism are not clear. We generated conditional knockout mice of the endoribonuclease component of the RNase P complex, MRPP3, and report ...
2016 / Oliver Rackham, Jakob D. Busch, Stanka Matic, Stefan J. Siira, Irina Kuznetsova, et al. -
Experience of contamination during autologous cell manufacturing in cell processing facility under the Japanese Medical Practitioners Act and the Medical Care Act
Abstract Cell therapy and regenerative medicine technologies require strict cell manufacturing procedures to be defined and addressed. Maintenance of the aseptic environment is critical to preclude extrinsic contamination risks, similar to...
2016 / Manabu Mizutani, Hazuki Samejima, Hiroshi Terunuma, Masahiro Kino-oka -
Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer2015 / Maria N. Timofeeva, Ben Kinnersley, Susan M. Farrington, Nicola Whiffin, Claire Palles, et al.
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MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage
Summary Microvascular endothelial cells maintain a tight barrier to prevent passage of plasma and circulating immune cells into the extravascular tissue compartment, yet endothelial cells respond rapidly to vasoactive substances, including thrombin, ...
2016 / Linda R. Klei, Dong Hu, Robert Panek, Danielle N. Alfano, Rachel E. Bridwell, et al. -
Plasmablasts During Acute Dengue Infection Represent a Small Subset of a Broader Virus-specific Memory B Cell Pool
Abstract Dengue is endemic in tropical countries worldwide and the four dengue virus serotypes often co-circulate. Infection with one serotype results in high titers of cross-reactive antibodies produced by plasmablasts, protecting temporarily...
2016 / Ramapraba Appanna, Srinivasan KG, Mei Hui Xu, Ying-Xiu Toh, Sumathy Velumani, et al. -
Updated checklist of scale insects ( Hemiptera: Coccomorpha ) in Sakartvelo (Georgia)
Abstract The Scale Insects, infraorder Coccomorpha (Hemiptera: Sternorryncha) includes many agricultural pests. The latest check list of scale insects of Sakartvelo (Republic of Georgia) was published in 2008, but it contained species mostly from...
2017 / M. Batsankalashvili, M.B. Kaydan, G. Kirkitadze, G. Japoshvili -
Assessment of somaclonal variation in somatic embryo-derived plants of yacon [Smallanthus sonchifolius (Poepp. and Endl.) H. Robinson] using inter simple sequence repeat analysis and flow cytometry
Abstract Background Yacon (Smallanthus sonchifolius) is a root crop native to the Andean region. Low sexual reproductive capacity is a major constraint facing the genetic breeding of this crop. Biotechnological techniques offer...
2014 / Iva Viehmannova, Zuzana Bortlova, Jan Vitamvas, Petra Hlasna Cepkova, Katerina Eliasova, et al. -
Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody
Summary Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the crystal structure of the IL-3 receptor α chain (IL3Rα) in complex with the...
2014 / Sophie E. Broughton, Timothy R. Hercus, Matthew P. Hardy, Barbara J. McClure, Tracy L. Nero, et al. -
Distinct functional responses to stressors of bone marrow derived dendritic cells from diverse inbred chicken lines
Abstract Differences in responses of chicken bone marrow derived dendritic cells (BMDC) to in vitro treatment with lipopolysaccharide (LPS), heat, and LPS + heat were identified. The Fayoumi is more disease resistant and heat tolerant than the...
2016 / Angelica Van Goor, Anna Slawinska, Carl J. Schmidt, Susan J. Lamont -
Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells
Summary The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through its catalytic subunit Ezh2. PRC2-mediated di- and tri-methylation (H3K27me2/H3K27me3) have been interchangeably associated with gene repression....
2016 / Aster H. Juan, Stan Wang, Kyung Dae Ko, Hossein Zare, Pei-Fang Tsai, et al. -
Generation of an induced pluripotent stem cell line from a patient with chronic myeloid leukemia (CML) resistant to targeted therapies
Abstract Chronic myeloid leukemia (CML) is a clonal malignancy initiated by the occurrence of a t (9;22) translocation, generating Ph1 chromosome and BCR-ABL oncogene in a primitive hematopoietic stem cell (HSC). The resistance of HSC to targeted...
2016 / G. Telliam, O. Féraud, F. Griscelli, P. Opolon, D. Divers, et al. -
Cellular minichromosome maintenance complex component 5 (MCM5) is incorporated into HIV-1 virions and modulates viral replication in the newly infected cells
Abstract The post-entry events of HIV-1 infection occur within reverse transcription complexes derived from the viral cores entering the target cell. HIV-1 cores contain host proteins incorporated from virus-producing cells. In this report, we show...
2016 / Steven Santos, Yuri Obukhov, Sergei Nekhai, Tatiana Pushkarsky, Beda Brichacek, et al.