Biological sciences topic list of research papers
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Seasonal controls on grassland microbial biogeography: Are they governed by plants, abiotic properties or both?
Abstract Temporal dynamics create unique and often ephemeral conditions that can influence soil microbial biogeography at different spatial scales. This study investigated the relation between decimeter to meter spatial variability of soil microbial ...
2014 / Kathleen M. Regan, Naoise Nunan, Runa S. Boeddinghaus, Vanessa Baumgartner, Doreen Berner, et al. -
Steady-state and time-resolved Thioflavin-T fluorescence can report on morphological differences in amyloid fibrils formed by Aβ(1-40) and Aβ(1-42)
Abstract Thioflavin-T (ThT) is one of the most commonly used dyes for amyloid detection, but the origin of its fluorescence enhancement is not fully understood. Herein we have characterised the ThT fluorescence response upon binding to the Aβ(1-40)...
2015 / David J. Lindberg, Moa S. Wranne, Mélina Gilbert Gatty, Fredrik Westerlund, Elin K. Esbjörner -
Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice
Abstract Regulation of intestinal secretion is important for body fluid homeostasis. We investigated the role of three MAP kinases (MAPKs) as negative regulators in muscarinic cholinoceptor (mAChR)-mediated intestinal secretion in mice....
2014 / Md Rafiqul Islam Khan, Md Tariqul Islam, Takashi Yazawa, Hisayoshi Hayashi, Yuichi Suzuki, et al. -
The Moraxella catarrhalis-induced pro-inflammatory immune response is enhanced by the activation of the epidermal growth factor receptor in human pulmonary epithelial cells
Abstract Background Chronic lower airway inflammation is considered to be a major cause of pathogenesis and disease progression in chronic obstructive pulmonary disease (COPD). Moraxella catarrhalis is a COPD-associated pathogen...
2014 / Philippe Dje N'Guessan, Helge Haarmann, Tamara Steiner, Kerstin Heyl, Frauke Schreiber, et al. -
MiR-495 suppresses mesendoderm differentiation of mouse embryonic stem cells via the direct targeting of Dnmt3a
Abstract Embryonic stem cells (ESCs) are promising resources for clinical therapies due to their potential to generate multiple cell types. The dynamic expression of de novo methyltransferases (Dnmt3a and Dnmt3b) is essential to ESCs; however, the...
2014 / Dandan Yang, Guiying Wang, Songcheng Zhu, Qidong Liu, Tingyi Wei, et al. -
Genetics of Follicular Lymphoma Transformation
Summary Follicular lymphoma (FL) is an indolent disease, but 30%–40% of cases undergo histologic transformation to an aggressive malignancy, typically represented by diffuse large B cell lymphoma (DLBCL). The pathogenesis of this process remains...
2014 / Laura Pasqualucci, Hossein Khiabanian, Marco Fangazio, Mansi Vasishtha, Monica Messina, et al. -
Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1
Summary Efficient stop codon recognition and peptidyl-tRNA hydrolysis are essential in order to terminate translational elongation and maintain protein sequence fidelity. Eukaryotic translational termination is mediated by a release factor complex...
2014 / Tianshu Feng, Atsushi Yamamoto, Sarah E. Wilkins, Elizaveta Sokolova, Luke A. Yates, et al. -
Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic
Summary The GGGGCC (G4C2) intronic repeat expansion within C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Intranuclear neuronal RNA foci have been observed in ALS and FTD tissues,...
2013 / Youn-Bok Lee, Han-Jou Chen, João N. Peres, Jorge Gomez-Deza, Jan Attig, et al. -
Human Developmental Chondrogenesis as a Basis for Engineering Chondrocytes from Pluripotent Stem Cells
Summary Joint injury and osteoarthritis affect millions of people worldwide, but attempts to generate articular cartilage using adult stem/progenitor cells have been unsuccessful. We hypothesized that recapitulation of the human developmental...
2013 / Ling Wu, Carolina Bluguermann, Levon Kyupelyan, Brooke Latour, Stephanie Gonzalez, et al. -
Induction of the proapoptotic tumor suppressor gene Cell Adhesion Molecule 1 by chemotherapeutic agents is repressed in therapy resistant acute myeloid leukemia2014 / Muriel C. Fisser, Anna Rommer, Katarina Steinleitner, Gerwin Heller, Friederike Herbst, et al.
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Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis2014 / Damien Portevin, Sudarkodi Sukumar, Mireia Coscolla, Guanghou Shui, Bowen Li, et al.
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Production of highly bioactive resveratrol analogues pterostilbene and piceatannol in metabolically engineered grapevine cell cultures2016 / Ascensión Martínez-Márquez, Jaime A. Morante-Carriel, Karla Ramírez-Estrada, Rosa M. Cusidó, Javier Palazon, et al.
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Sequence Analysis of the 36-kb Region Between gntZ and trnY Genes of Bacillus Subtilis Genome*2005 / Y. Kasahara
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Detecting microvascular changes in the mouse spleen using optical computed tomography
Abstract Methods of monitoring drug toxicity in off-target organs are very important in the development of effective and safe drugs. Standard 2-D techniques, such as histology, are prone to sampling errors and can miss important information. We...
2015 / Ciara M. McErlean, Jessica K.R. Boult, David J. Collins, Martin O. Leach, Simon P. Robinson, et al. -
Genome-wide association analyses reveal complex genetic architecture underlying natural variation for flowering time in canola2015 / Harsh Raman, Rosy Raman, Neil Coombes, Jie Song, Roslyn Prangnell, et al.
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Increased gene dosage of Ink4/Arf and p53 delays age-associated central nervous system functional decline2015 / Estefania Carrasco-Garcia, Olatz Arrizabalaga, Manuel Serrano, Robin Lovell-Badge, Ander Matheu
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Towards a comprehensive atlas of cortical connections in a primate brain: Mapping tracer injection studies of the common marmoset into a reference digital template2016 / Piotr Majka, Tristan A. Chaplin, Hsin-Hao Yu, Alexander Tolpygo, Partha P. Mitra, et al.
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Mean reproductive traits of fungal assemblages are correlated with resource availability2016 / Claus Bässler, Hans Halbwachs, Peter Karasch, Heinrich Holzer, Andreas Gminder, et al.
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Diversity and population structure of northern switchgrass as revealed through exome capture sequencing2015 / Joseph Evans, Emily Crisovan, Kerrie Barry, Chris Daum, Jerry Jenkins, et al.
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Quantification of correlational selection on thermal physiology, thermoregulatory behavior, and energy metabolism in lizards2015 / Paulina Artacho, Julia Saravia, Beatriz Decencière Ferrandière, Samuel Perret, Jean-François Le Galliard