Biological sciences topic list of research papers
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Effects of fragment traits, burial orientation and nutrient supply on survival and growth in Populus deltoides × P. simonii2016 / Ping Zhang, Zhi-Qin Su, Lie Xu, Xue-Ping Shi, Ke-Bing Du, et al.
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Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments
Abstract The behavior and fate of cells in tissues largely rely upon their cross-talk with the tissue microenvironment including neighboring cells, the extracellular matrix (ECM), and soluble cues from the local and systemic environments....
2014 / Allan Yi Liu, Hong Zheng, Gaoliang Ouyang -
Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor
Summary Estrogen receptor-α (ER) is the driving transcription factor in most breast cancers, and its associated proteins can influence drug response, but direct methods for identifying interacting proteins have been limited. We purified endogenous...
2013 / Hisham Mohammed, Clive D’Santos, Aurelien A. Serandour, H. Raza Ali, Gordon D. Brown, et al. -
Abrupt community transitions and cyclic evolutionary dynamics in complex food webs
Abstract Understanding the emergence and maintenance of biodiversity ranks among the most fundamental challenges in evolutionary ecology. While processes of community assembly have frequently been analyzed from an ecological perspective, their...
2013 / Daisuke Takahashi, Åke Brännström, Rupert Mazzucco, Atsushi Yamauchi, Ulf Dieckmann -
Abnormal uterine artery remodelling in the stroke prone spontaneously hypertensive rat
Abstract Introduction The stroke prone spontaneously hypertensive rat (SHRSP) is an established model of human cardiovascular risk. We sought to characterise the uteroplacental vascular response to pregnancy in this model and...
2015 / Heather Y. Small, Hannah Morgan, Elisabeth Beattie, Sinead Griffin, Marie Indahl, et al. -
Effect of isolated AMP deaminase deficiency on skeletal muscle function
Abstract Mutation of the AMP deaminase 1 (AMPD1) gene, the predominate AMPD gene expressed in skeletal muscle, is one of the most common inherited defects in the Caucasian population; 2–3% of individuals in this ethnic group are homozygous for...
2014 / Jidong Cheng, Hiroko Morisaki, Naomi Sugimoto, Atsushi Dohi, Takuya Shintani, et al. -
HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo
Abstract Hypoxia affects many physiologic processes during early stages of mammalian ontogeny, particularly placental and vascular development. In the adult, the hypoxic bone marrow microenvironment plays a role in regulating hematopoietic stem cell ...
2013 / Parisa Imanirad, Parham Solaimani Kartalaei, Mihaela Crisan, Chris Vink, Tomoko Yamada-Inagawa, et al. -
Dominant Mutations in GRHL3 Cause Van der Woude Syndrome and Disrupt Oral Periderm Development
Mutations in interferon regulatory factor 6 (IRF6) account for ∼70% of cases of Van der Woude syndrome (VWS), the most common syndromic form of cleft lip and palate. In 8 of 45 VWS-affected families lacking a mutation in IRF6, we found coding mutations in...
2013 / Myriam Peyrard-Janvid, Elizabeth J. Leslie, Youssef A. Kousa, Tiffany L. Smith, Martine Dunnwald, et al. -
Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure2013 / Salome Scholtens, Dirkje S. Postma, Miriam F. Moffatt, Sviatlana Panasevich, Raquel Granell, et al.
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Mutations in PGAP3 Impair GPI-Anchor Maturation, Causing a Subtype of Hyperphosphatasia with Mental Retardation
Glycosylphophatidylinositol (GPI)-anchored proteins play important roles in many biological processes, and mutations affecting proteins involved in the synthesis of the GPI anchor are reported to cause a wide spectrum of intellectual disabilities (IDs) with...
2014 / Malcolm F. Howard, Yoshiko Murakami, Alistair T. Pagnamenta, Cornelia Daumer-Haas, Björn Fischer, et al. -
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population2014 / Elaine T. Lim, Peter Würtz, Aki S. Havulinna, Priit Palta, Taru Tukiainen, et al.
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Development of a Bacillus subtilis cell-free transcription-translation system for prototyping regulatory elements
Abstract Cell-free transcription-translation systems were originally applied towards in vitro protein production. More recently, synthetic biology is enabling these systems to be used within a systematic design context for prototyping DNA regulatory ...
2016 / Richard Kelwick, Alexander J. Webb, James T. MacDonald, Paul S. Freemont -
Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing
Abstract Flavonoids, a group of dietary polyphenols have been shown to possess cognitive health benefits. Epidemiologic evidence suggests that they could play a role in risk reduction in dementia. Amyloid precursor protein processing and the...
2014 / Carla J. Cox, Fahd Choudhry, Eleanor Peacey, Michael S. Perkinton, Jill C. Richardson, et al. -
The histone acetyltransferase MOF activates hypothalamic polysialylation to prevent diet-induced obesity in mice
Abstract Overfeeding causes rapid synaptic remodeling in hypothalamus feeding circuits. Polysialylation of cell surface molecules is a key step in this neuronal rewiring and allows normalization of food intake. Here we examined the role of...
2014 / Xavier Brenachot, Caroline Rigault, Emmanuelle Nédélec, Amélie Laderrière, Tasneem Khanam, et al. -
CD103+ Dendritic Cells Control Th17 Cell Function in the Lung
Summary Th17 cells express diverse functional programs while retaining their Th17 identity, in some cases exhibiting a stem-cell-like phenotype. Whereas the importance of Th17 cell regulation in autoimmune and infectious diseases is firmly...
2015 / Teresa Zelante, Alicia Yoke Wei Wong, Tang Jing Ping, Jinmiao Chen, Hermi R. Sumatoh, et al. -
Early Divergent Strains of Yersinia pestis in Eurasia 5,000 Years Ago
Summary The bacteria Yersinia pestis is the etiological agent of plague and has caused human pandemics with millions of deaths in historic times. How and when it originated remains contentious. Here, we report the oldest direct evidence of Yersinia...
2015 / Simon Rasmussen, Morten Erik Allentoft, Kasper Nielsen, Ludovic Orlando, Martin Sikora, et al. -
Epileptogenesis and epileptic maturation in phosphorylation site-specific SNAP-25 mutant mice
Summary Snap25 S187A/S187A mouse is a knock-in mouse with a single amino acid substitution at a protein kinase C-dependent phosphorylation site of the...
2015 / Shigeru Watanabe, Saori Yamamori, Shintaro Otsuka, Masanori Saito, Eiji Suzuki, et al. -
Long noncoding RNA MRCCAT1 promotes metastasis of clear cell renal cell carcinoma via inhibiting NPR3 and activating p38-MAPK signaling2017 / Jia-Kuan Li, Cheng Chen, Jia-Yi Liu, Jia-Zi Shi, Shu-Peng Liu, et al.
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Effects of exogenous ABA application on post-anthesis dry matter redistribution and grain starch accumulation of winter wheat with different staygreen characteristics
Abstract The objective of this study was to investigate whether and how exogenous abscisic acid (ABA) is involved in mediating starch accumulation in the grain and redistribution of carbohydrates during grain filling of two wheat cultivars with...
2014 / Dongqing Yang, Yongli Luo, Yingli Ni, Yanping Yin, Weibing Yang, et al. -
Landscape structure and genetic architecture jointly impact rates of niche evolution2014 / Katja Schiffers, Frank M. Schurr, Justin M. J. Travis, Anne Duputié, Vincent M. Eckhart, et al.