Biological sciences topic list of research papers
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Novel candidate genes for 46,XY gonadal dysgenesis identified by a customized 1 M array-CGH platform
Abstract Half of all patients with a disorder of sex development (DSD) do not receive a specific molecular diagnosis. Comparative genomic hybridization (CGH) can detect copy number changes causing gene haploinsufficiency or over-expression that can...
2013 / Ameli Norling, Angelica Lindén Hirschberg, Erik Iwarsson, Bengt Persson, Anna Wedell, et al. -
Key Role of Mfd in the Development of Fluoroquinolone Resistance in Campylobacter jejuni2008 / Jing Han, Orhan Sahin, Yi-Wen Barton, Qijing Zhang
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The role of KIR genes and ligands in leukemia surveillance2013 / Florian Babor, Johannes C. Fischer, Markus Uhrberg
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Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice2012 / Norbert Weissmann, Akylbek Sydykov, Hermann Kalwa, Ursula Storch, Beate Fuchs, et al.
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Genomic and secretomic insight into lignocellulolytic system of an endophytic bacterium Pantoea ananatis Sd-12016 / Jiangshan Ma, Keke Zhang, Hongdong Liao, Stanton B. Hector, Xiaowei Shi, et al.
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Spontaneous Skin Erosions and Reduced Skin and Corneal Wound Healing Characterize CLIC4NULL Mice
Cutaneous wound healing is a complex process involving blood clotting, inflammation, migration of keratinocytes, angiogenesis, and, ultimately, tissue remodeling and wound closure. Many of these processes involve transforming growth factor-β (TGF-β) signaling, and ...
2012 / V.C. Padmakumar, Kelsey Speer, Sonali Pal-Ghosh, Katelyn E. Masiuk, Andrew Ryscavage, et al. -
Macrophage β2 Integrin–Mediated, HuR-Dependent Stabilization of Angiogenic Factor–Encoding mRNAs in Inflammatory Angiogenesis
HuR is a member of the Drosophila Elav protein family that binds mRNA degradation sequences and prevents RNase-mediated degradation. Such HuR-mediated mRNA stabilization, which is stimulated by integrin engagement and is controlled at the level of HuR nuclear...
2012 / Jiange Zhang, Yasha Modi, Timur Yarovinsky, Jun Yu, Mark Collinge, et al. -
p53 and Mitochondrial DNA
The roles and actions of the tumor suppressor protein p53 have been extensively studied with regard to nuclear events, including transcription and DNA damage repair. However, the direct roles of p53 in mitochondrial DNA (mtDNA) replication and function are less...
2012 / Christopher A. Koczor, Richard C. White, Peter Zhao, Linjue Zhu, Earl Fields, et al. -
Role of the Nuclear Receptor Coactivator AIB1/SRC-3 in Angiogenesis and Wound Healing
The nuclear receptor coactivator amplified in breast cancer 1 (AIB1/SRC-3) has a well-defined role in steroid and growth factor signaling in cancer and normal epithelial cells. Less is known about its function in stromal cells, although AIB1/SRC-3 is up-regulated...
2012 / Maram Al-Otaiby, Elena Tassi, Marcel O. Schmidt, Chris D. Chien, Tabari Baker, et al. -
Interactions of the Melanocortin-4 Receptor with the Peptide Agonist NDP-MSH
Abstract Melanocortin-4 receptor (MC4R) has an important regulatory role in energy homeostasis and food intake. Peptide agonists of the MC4R are characterized by the conserved sequence His6-Phe7-Arg8-Trp9, which is crucial for their interaction with ...
2010 / Kathryn L. Chapman, Gemma K. Kinsella, Alan Cox, Dan Donnelly, John B.C. Findlay -
Dystroglycan is associated to the disulfide isomerase ERp57
Abstract Dystroglycan (DG) is an extracellular receptor composed of two subunits, α-DG and β-DG, connected through the α-DG C-terminal domain and the β-DG N-terminal domain. We report an alanine scanning of all DG cysteine residues performed on...
2012 / Francesca Sciandra, Emanuela Angelucci, Fabio Altieri, Daniela Ricci, Wolfgang Hübner, et al. -
Targeting Glioma Stem Cells by Functional Inhibition of a Prosurvival OncomiR-138 in Malignant Gliomas
Summary Malignant gliomas are the most aggressive forms of brain tumors, associated with high rates of morbidity and mortality. Recurrence and tumorigenesis are attributed to a subpopulation of tumor-initiating glioma stem cells (GSCs) that are...
2012 / Xin Hui Derryn Chan, Srikanth Nama, Felicia Gopal, Pamela Rizk, Srinivas Ramasamy, et al. -
Bone Morphogenetic Protein/SMAD Signaling Orients Cell Fate Decision by Impairing KSRP-Dependent MicroRNA Maturation
Summary MicroRNAs (miRNAs) are essential regulators of development, physiology, and evolution, and their biogenesis is strictly controlled at multiple levels. Regulatory proteins, such as KSRP, modulate rates and timing of enzymatic reactions...
2012 / Michela Pasero, Matteo Giovarelli, Gabriele Bucci, Roberto Gherzi, Paola Briata -
Genetic variability of innate immunity impacts human susceptibility to fungal diseases
Abstract Fungi are a major threat in immunocompromised patients. Despite presenting similar degrees of immunosuppression, not all individuals at-risk ultimately develop fungal diseases. The traditional view of immune suppression as a key risk factor ...
2009 / Agostinho Carvalho, Cristina Cunha, Alessandro C. Pasqualotto, Lucia Pitzurra, David W. Denning, et al. -
Global ocean conveyor lowers extinction risk in the deep sea
Abstract General paradigms of species extinction risk are urgently needed as global habitat loss and rapid climate change threaten Earth with what could be its sixth mass extinction. Using the stony coral Lophelia pertusa as a model organism with...
2014 / Lea-Anne Henry, Norbert Frank, Dierk Hebbeln, Claudia Wienberg, Laura Robinson, et al. -
The macrosemiiform fish companion of the Late Jurassic theropod Juravenator from Schamhaupten, Bavaria, Germany2012 / Gloria Arratia, Hans-Peter Schultze
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Cannibalism in a small growth stage of the Early Permian branchiosaurid Apateon gracilis (Credner, 1881) from Saxony2009 / Florian Witzmann
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MicroRNAs as potential biomarkers for VERO cell tumorigenicity
Abstract MicroRNA expression appears to capture the process of neoplastic development in vitro in the VERO line of African green monkey kidney (AGMK) cells (Teferedegne et al. PLoS One 2010;5(12):e14416). In that study, specific miRNA signatures...
2014 / Belete Teferedegne, Juliete Macauley, Gideon Foseh, Eugenia Dragunsky, Konstantin Chumakov, et al. -
The Development and Characterization of a Human Mesothelioma In Vitro 3D Model to Investigate Immunotoxin Therapy2011 / Xinran Xiang, Yen Phung, Mingqian Feng, Kunio Nagashima, Jingli Zhang, et al.
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A synthetic luxCDABE gene cluster optimized for expression in high-GC bacteria2007 / A. Craney, T. Hohenauer, Y. Xu, N. K. Navani, Y. Li, et al.