Biological sciences topic list of research papers
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Butyrylcholinesterase and the cholinergic system
Abstract The cholinergic system plays important roles in neurotransmission in both the peripheral and central nervous systems. The cholinergic neurotransmitter acetylcholine is synthesized by choline acetyltransferase (ChAT) and its action...
2013 / G.A. Reid, N. Chilukuri, S. Darvesh -
Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation
Abstract Tobacco smoke exerts perturbations on lipid metabolism and arterial cell function that accelerate atherosclerosis. Lipidomics has emerged as a key technology in helping to elucidate the lipid-related mechanisms of atherosclerosis. In this...
2013 / Michael Lietz, An Berges, Stefan Lebrun, Kris Meurrens, Yvonne Steffen, et al. -
The capacious hologenome
Abstract Blending disciplines can be transformative in science, yet interdisciplinary mergers should not escape healthy skepticism. Indeed, the history of biology shows us that debates about the relative importance of nuclear genetics vs. microbial...
2013 / Robert M. Brucker, Seth R. Bordenstein -
Olive Agroecosystems in the Mediterranean Basin: Multitrophic Analysis of Climate Effects with Process-based Representation of Soil Water Balance
Abstract Olive is of major eco-social importance for the Mediterranean Basin, a climate change and biodiversity hotspot of global relevance where remarkable climate change is expected over the next few decades with unknown ecosystem impacts....
2013 / Luigi Ponti, Andrew Paul Gutierrez, Bruno Basso, Markus Neteler, Paolo Michele Ruti, et al. -
Conformational Plasticity of an Enzyme during Catalysis: Intricate Coupling between Cyclophilin A Dynamics and Substrate Turnover
Abstract Enzyme catalysis is central to almost all biochemical processes, speeding up rates of reactions to biological relevant timescales. Enzymes make use of a large ensemble of conformations in recognizing their substrates and stabilizing the...
2013 / Lauren C. McGowan, Donald Hamelberg -
Cigarette smoking and alcohol drinking in a representative sample of English school pupils: Cross-sectional and longitudinal associations
Abstract Objective The aim of our study was to examine cross-sectional and longitudinal associations between cigarette smoking and alcohol drinking, in a representative sample of English pupils. ...
2013 / Gareth Hagger-Johnson, Steven Bell, Annie Britton, Noriko Cable, Mark Conner, et al. -
Uncoupling VEGFA Functions in Arteriogenesis and Hematopoietic Stem Cell Specification
Summary VEGFA signaling is critical for endothelial and hematopoietic stem cell (HSC) specification. However, blood defects resulting from perturbation of the VEGFA pathway are always accompanied by impaired vascular/arterial development. Because...
2013 / Amy Leung, Aldo Ciau-Uitz, Philip Pinheiro, Rui Monteiro, Jie Zuo, et al. -
Deubiquitylating enzymes and their emerging role in plant biology2014 / Erika Isono, Marie-Kristin Nagel
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pRb-Independent Growth Arrest and Transcriptional Regulation of E2F Target Genes
Abstract The retinoblastoma tumor suppressor (pRb) has traditionally been studied as a negative regulator of cell cycle progression through its interactions with the E2F family of transcription factors. Utilizing prostate epithelial cell lines...
2006 / Michael T. McCabe, Odinaka J. Azih, Mark L. Day -
HLA-DR+ Immature Cells Exhibit Reduced Antigen-Presenting Cell Function But Respond to CD40 Stimulation
Abstract Dendritic cells (DC) have been implicated in the defective function of the immune system during cancer progression. We have demonstrated that patients with cancer have fewer myeloid (CD11c+) and plasmacytoid (CD123hi) DC and a concurrent...
2006 / Alberto Pinzon-Charry, Tammy Maxwell, Sandro Prato, Colin Furnival, Chris Schmidt, et al. -
Studying the RNA silencing pathway with the p19 protein
Abstract The origins of the RNA silencing pathway are in defense against invading viruses and in response, viruses have evolved counter-measures to interfere with the host pathway. The p19 protein is expressed by tombusviruses as a suppressor of RNA ...
2013 / Dana C. Danielson, John Paul Pezacki -
Caenorhabditis elegans anillin (ani-1) regulates neuroblast cytokinesis and epidermal morphogenesis during embryonic development
Abstract The formation of tissues is essential for metazoan development. During Caenorhabditis elegans embryogenesis, ventral epidermal cells migrate to encase the ventral surface of the embryo in a layer of epidermis by a process known as ventral...
2013 / N. Fotopoulos, D. Wernike, Y. Chen, N. Makil, A. Marte, et al. -
Dissecting the divergent effects of interferon-alpha on immune cells: Time to rethink combination therapy in chronic hepatitis B?2012 / Robert Thimme, Maura Dandri
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Root-inhabiting fungi in alien plant species in relation to invasion status and soil chemical properties2015 / Marta L. Majewska, Janusz Błaszkowski, Marcin Nobis, Kaja Rola, Agnieszka Nobis, et al.
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Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1
Abstract Cigarette smoking remains a major health concern worldwide, and many of the adverse effects of cigarette smoke (CS) can be attributed to its abundant electrophilic aldehydes, such as acrolein (2-propenal). Previous studies indicate that...
2013 / Matthew J. Randall, Page C. Spiess, Milena Hristova, Robert J. Hondal, Albert van der Vliet -
Structural insights into the activation of MST3 by MO25
Abstract The MO25 scaffolding protein operates as critical regulator of a number of STE20 family protein kinases (e.g. MST and SPAK isoforms) as well as pseudokinases (e.g. STRAD isoforms that play a critical role in activating the LKB1 tumour...
2013 / Youcef Mehellou, Dario R. Alessi, Thomas J. Macartney, Marta Szklarz, Stefan Knapp, et al. -
Concentration and Purification of Galactoglucomannans from Wood Pressurized Hot Water Extraction Liquors by High Shear Rate Ultrafiltration2012 / M. AlManasrah, M. Kallioinen, M. Mänttäri
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The Rumsfeld paradox: some of the things we know that we don’t know about plant virus infection
Plant-infecting viruses cause significant crop losses around the world and the majority of emerging threats to crop production have a viral etiology. Significant progress has been made and continues to be made in understanding how viruses induce disease and...
2013 / Peter Palukaitis, Simon C Groen, John P Carr -
Evolutionary aspects of a unique internal mitochondrial targeting signal in nuclear-migrated rps19 of sugar beet (Beta vulgaris L.)
Abstract The endosymbiotic theory postulates that many genes migrated from endosymbionts to the nuclear genomes of their hosts. Some migrated genes lack presequences directing proteins to mitochondria, and their mitochondrial targeting signals...
2013 / Muneyuki Matsunaga, Yoshiya Takahashi, Rika Yui-Kurino, Tetsuo Mikami, Tomohiko Kubo -
SPIRAL2 Determines Plant Microtubule Organization by Modulating Microtubule Severing
Summary One of the defining characteristics of plant growth and morphology is the pivotal role of cell expansion. While the mechanical properties of the cell wall determine both the extent and direction of cell expansion, the cortical microtubule...
2013 / Raymond Wightman, Guillaume Chomicki, Manoj Kumar, Paul Carr, Simon R. Turner