Basic medicine topic list of research papers
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Human pluripotent stem cell-derived cardiomyocytes: Genome-wide expression profiling of long-term in vitro maturation in comparison to human heart tissue
Abstract Cardiomyocyte-like cells (CMs) derived from human pluripotent stem cells (hPSCs) present a valuable model for human disease modeling, studying early human development and, potentially, developing cell therapeutic approaches. However, the...
2015 / Ilaria Piccini, Jyoti Rao, Guiscard Seebohm, Boris Greber -
Autonomic regulation therapy suppresses quantitative T-wave alternans and improves baroreflex sensitivity in patients with heart failure enrolled in the ANTHEM-HF study
Background Autonomic regulation therapy (ART) with chronic vagus nerve stimulation improves ventricular function in patients with chronic heart failure, but its effects on quantitative T-wave alternans (TWA), ventricular tachycardia (VT),...
2015 / Imad Libbus, Bruce D. Nearing, Badri Amurthur, Bruce H. KenKnight, Richard L. Verrier -
Febuxostat pretreatment attenuates myocardial ischemia/reperfusion injury via mitochondrial apoptosis2015 / Shulin Wang, Yunpeng Li, Xudong Song, Xianbao Wang, Cong Zhao, et al.
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I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model
Abstract Aims Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, diastolic dysfunction and increased interstitial fibrosis. Current treatment is based on beta-adrenoceptor (AR) and calcium channel...
2015 / Felix W. Friedrich, Hannieh Sotoud, Birgit Geertz, Silvio Weber, Frederik Flenner, et al. -
Hypertrophy induced KIF5B controls mitochondrial localization and function in neonatal rat cardiomyocytes
Abstract Cardiac hypertrophy is associated with growth and functional changes of cardiomyocytes, including mitochondrial alterations, but the latter are still poorly understood. Here we investigated mitochondrial function and dynamic localization in ...
2016 / Wardit Tigchelaar, Anne Margreet de Jong, Vincent W. Bloks, Wiek H. van Gilst, Rudolf A. de Boer, et al. -
Oral treatment with a zinc complex of acetylsalicylic acid prevents diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of the Akt pathway2016 / Sevil Korkmaz-Icöz, Samer Al Said, Tamás Radovits, Shiliang Li, Maik Brune, et al.
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Using MRI to predict future adverse cardiac remodelling in a male mouse model of myocardial infarction
Abstract Background Mice are frequently used in research to examine outcomes of myocardial infarction (MI) and to investigate therapeutic interventions at an early pre-clinical stage. The MI model is generated by surgically...
2016 / Rachael E. Redgrave, Simon Tual-Chalot, Benjamin J. Davison, Elizabeth Greally, Mauro Santibanez-Koref, et al. -
Short-and long-term effects of ischemic postconditioning in STEMI patients: a meta-analysis2015 / Jing Gao, Junyi Luo, Fen Liu, Yingying Zheng, Bangdang Chen, et al.
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Left atrial volume index as a predictor of left ventricular remodeling in patients with anterior STEMI treated with primary PCI
Abstract Background Left ventricular remodeling (LVR) after myocardial infarction (MI) is associated with adverse cardiovascular events. Left atrial volume index (LAVI) was emerged as a prognostic factor for cardiovascular outcome. ...
2015 / Mohamed Naseem, Sameh Samir -
Could early septal involvement in the remodeling process be related to the advance hypertensive heart disease?
Abstract Background Quantitative imaging analyses showed an earlier septal wall involvement in hypertension. We planned to determine the effect of hypertension on regional myocardial performance index (MPI) in a hypertensive...
2015 / Fatih Yalçin, Caner Topaloglu, Nagehan Kuçukler, Mehmet Ofgeli, Theodore P. Abraham -
Moving in extreme environments: extreme loading; carriage versus distance2016 / Samuel J. E. Lucas, Jørn W. Helge, Uwe H. W. Schütz, Ralph F. Goldman, James D. Cotter
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Effects of aerobic training on serum paraoxonase activity and its relationship with PON1-192 phenotypes in women
Abstract Background Paraoxonase 1 (PON1) is an antioxidant enzyme that protects high-density lipoprotein (HDL) and low-density lipoprotein against oxidation. Limited studies have addressed the influence of exercise on PON1 activity ...
2015 / Gulbin Rudarli Nalcakan, S. Rana Varol, Faruk Turgay, Mesut Nalcakan, M. Zeki Ozkol, et al. -
Evaluation of sleep related breathing problems and sleep disturbances among health related employees at Fayoum University Hospitals
Abstract Sleep plays a role in normal metabolism and immunity. Short sleep duration and circadian misalignment are hypothesized to causally contribute to health problems including obesity, diabetes, metabolic syndrome, heart disease, mood disorders, ...
2016 / Radwa Ahmed Elhefny, Sherine El Mously, Sayed Sobhi, Wafaa Yousif Abdel Wahed -
Atorvastatin treatment improves effects of implanted mesenchymal stem cells: meta-analysis of animal models with acute myocardial infarction2015 / Guo Dai, Qing Xu, Rong Luo, Jianfang Gao, Hui Chen, et al.
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Heart failure in chemotherapy-related cardiomyopathy: Can exercise make a difference?
Abstract Medical therapies in oncology have resulted in better survival resulting in a large population who are at risk of early and late cardiac complications of chemotherapy. Cardiotoxicity related to chemotherapy can manifest decades after...
2016 / Nandini Nair, Enrique Gongora -
Regulation of Gene Expression by Exercise-Related Micrornas2016 / Laureane Nunes Masi, Tamires Duarte Afonso Serdan, Adriana Cristina Levada-Pires, Elaine Hatanaka, Leonardo dos Reis Silveira, et al.
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The role of levosimendan in acute heart failure complicating acute coronary syndrome: A review and expert consensus opinion
Abstract Acute heart failure and/or cardiogenic shock are frequently triggered by ischemic coronary events. Yet, there is a paucity of randomized data on the management of patients with heart failure complicating acute coronary syndrome, as acute...
2016 / Markku S. Nieminen, Michael Buerke, Alain Cohen-Solál, Susana Costa, István Édes, et al. -
In-hospital journey of patients with heart failure
Abstract The number of patients diagnosed with heart failure (HF) is gradually increasing as a result of the increase in the elderly population. As the proportion of patients admitted to the emergency room with the diagnosis of acute heart failure...
2015 / Hakki Kaya, Mehmet Birhan Yilmaz -
Association between clinical parameters and ST-segment resolution after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction
Abstract Background and objective The aim of this study was to evaluate and compare various parameters between complete and incomplete ST-segment resolution (STR) patients' groups and to identify associates of STR in patients with...
2016 / Ramūnas Unikas, Povilas Budrys -
Precursors of Hypertensive Heart Phenotype Develop in Healthy Adults
Abstract Objectives This study used high-resolution 3-dimensional cardiac magnetic resonance to define the anatomical and functional left ventricular (LV) properties associated with increasing systolic blood pressure (SBP) in a...
2015 / Antonio de Marvao, Timothy J.W. Dawes, Wenzhe Shi, Giuliana Durighel, Daniel Rueckert, et al.