Scholarly article on topic 'Graphical Abstract: ChemistryOpen 2/2014'

Graphical Abstract: ChemistryOpen 2/2014 Academic research paper on "Chemical sciences"

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Academic research paper on topic "Graphical Abstract: ChemistryOpen 2/2014"


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The cover picture shows two-dimensional separation of unfolded (green) and folded (red) forms of G-quadruplex DNA. The first dimension is kinetic capillary electrophoresis (KCE) separation of unfolded and folded DNA with different potassium ion concentrations in solution. The second dimension is ion mobility mass spectrometry separation of DNA conformers in the gas phase. The picture further shows DNA folding into a compact G-quadruplex structure, which is mediated by potassium ions. For more details, see the Full Paper by Maxim V. Berezovski and co-workers, on p. 58 ff.

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"We did not expect such a big difference in migration time between folded and unfolded DNA. Our initial guess was that we could measure only a thermodynamic folding constant, but not rate constants for the fast conformational change." More about the story behind the cover research can be found on p. 58.

G. G. Mironov, V. Okhonin, N. Khan, C. M. Clouthier, M. V. Berezovski*

Conformational Dynamics of DNA G-Quadruplex in Solution Studied by Kinetic Capillary Electrophoresis Coupled On-line with Mass Spectrometry


The earlier, the better! We report a novel synthesis of tetrazine-functional-ized artificial amino acids, the creation of a model tetrazine-containing penta-peptide using solid-phase peptide synthesis, and the facile and rapid bioorthogonal radiolabeling of this peptide using a 89Zr-desferrioxamine-labeled irans-cyclooctene.

B. M. Zeglis, F. Emmetiere, N. Pillarsetty, R. Weissleder, J. S. Lewis,* T. Reiner*

Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis

Easy, quick and green! Diaryliodonium salts are demonstrated as efficient aryl-ating agents of aliphatic alcohols under mild and metal-free conditions. The reaction proceeds at room temperature within 90 min to give alkyl aryl ethers in good to excellent yields.

R. Ghosh, E. Lindstedt, N. Jalalian, B. Olofsson*

Room Temperature, Metal-Free Arylation of Aliphatic Alcohols


Combining forces! Kinetic capillary electrophoresis is coupled on-line with mass spectrometry (KCE-MS) to study conformational dynamics of DNA G-quadruplexes in solution. Peak's shift and its widening in KCE help measure rate and equilibrium constants; and ion mobility spectrometry (IMS) provides relative sizes, absolute molecular masses and stoichiometry.

G. G. Mironov, V. Okhonin, N. Khan, C. M. Clouthier, M. V. Berezovski*

Conformational Dynamics of DNA G-Quadruplex in Solution Studied by Kinetic Capillary Electrophoresis Coupled On-line with Mass Spectrometry

ChemistryOPEN .^ChemPubSoc

M. Behrends, C. Wallinder, A. Wieckowska, M.-O. Guimond, A. Hallberg, N. Gallo-Payet, M. Larhed*

ET 65-75

)□ N-Aryl Isoleucine Derivatives as Angiotensin II AT2 Receptor Ligands

37-64 Y = H, Me, Et Z = y R

68-70 Y = ^ R" Z = H

Human not pig receptors! A series of benzamide substituted N-aryl isoleucine derivatives targeting the human AT2R have been synthesized. In this series, ligands with K values down to the single digit micromolar range have been identified. The presented data emphasize the importance of using human receptors in drug discovery programs.

* Author to whom correspondence should be addressed.

□ Supporting information on the WWW A video clip is available as Supporting Information

(see article for access details). on the WWW (see article for access details).

gfThis is an open-access article, published under the terms and condi- Contributions labeled with this symbol have been

tions of the Creative Commons Attribution Non Commercial License. judged as "Very Important Papers" by the referees.


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